Eupedia Forums
Site NavigationEupedia Top > Eupedia Forum & Japan Forum
Results 1 to 3 of 3

Thread: Genetic variation in the Han Chinese

  1. #1
    Advisor Achievements:
    VeteranThree Friends50000 Experience PointsRecommendation Second Class
    Awards:
    Posting Award
    Angela's Avatar
    Join Date
    02-01-11
    Posts
    8,130
    Points
    87,187
    Level
    91
    Points: 87,187, Level: 91
    Level completed: 87%, Points required for next Level: 263
    Overall activity: 99.3%


    Ethnic group
    Italian
    Country: USA - New York



    Genetic variation in the Han Chinese

    See:
    http://www.biorxiv.org/content/early/2017/07/13/162982

    "As are most non-European populations around the globe, the Han Chinese are relatively understudied in population and medical genetics studies. From low-coverage whole-genome sequencing of 11,670 Han Chinese women we present a catalog of 25,057,223 variants, including 548,401 novel variants that are seen at least 10 times in our dataset. Individuals from our study come from 19 out of 22 provinces across China, allowing us to study population structure, genetic ancestry, and local adaptation in Han Chinese. We identify previously unrecognized population structure along the East-West axis of China and report unique signals of admixture across geographical space, such as European influences among the Northwestern provinces of China. Finally, we identified a number of highly differentiated loci, indicative of local adaptation in the Han Chinese. In particular, we detected extreme differentiation among the Han Chinese at MTHFR, ADH7, and FADS loci, suggesting that these loci may not be specifically selected in Tibetan and Inuit populations as previously suggested. On the other hand, we find that Neandertal ancestry does not vary significantly across the provinces, consistent with admixture prior to the dispersal of modern Han Chinese. Furthermore, contrary to a previous report, Neandertal ancestry does not explain a significant amount of heritability in depression. Our findings provide the largest genetic data set so far made available for Han Chinese and provide insights into the history and population structure of the world's largest ethnic group."


    Non si fa il proprio dovere perchè qualcuno ci dica grazie, lo si fa per principio, per se stessi, per la propria dignità. Oriana Fallaci

  2. #2
    Advisor Achievements:
    Three FriendsVeteranTagger First Class50000 Experience PointsRecommendation First Class
    Awards:
    Discussion Ender
    LeBrok's Avatar
    Join Date
    18-11-09
    Location
    Calgary
    Posts
    9,502
    Points
    86,278
    Level
    91
    Points: 86,278, Level: 91
    Level completed: 39%, Points required for next Level: 1,172
    Overall activity: 99.5%

    Y-DNA haplogroup
    R1b1b2a
    MtDNA haplogroup
    H1c

    Ethnic group
    Citizen of the world
    Country: Canada-Alberta



    Quote Originally Posted by Angela View Post
    See:
    http://www.biorxiv.org/content/early/2017/07/13/162982

    "As are most non-European populations around the globe, the Han Chinese are relatively understudied in population and medical genetics studies. From low-coverage whole-genome sequencing of 11,670 Han Chinese women we present a catalog of 25,057,223 variants, including 548,401 novel variants that are seen at least 10 times in our dataset. Individuals from our study come from 19 out of 22 provinces across China, allowing us to study population structure, genetic ancestry, and local adaptation in Han Chinese. We identify previously unrecognized population structure along the East-West axis of China and report unique signals of admixture across geographical space, such as European influences among the Northwestern provinces of China. Finally, we identified a number of highly differentiated loci, indicative of local adaptation in the Han Chinese. In particular, we detected extreme differentiation among the Han Chinese at MTHFR, ADH7, and FADS loci, suggesting that these loci may not be specifically selected in Tibetan and Inuit populations as previously suggested. On the other hand, we find that Neandertal ancestry does not vary significantly across the provinces, consistent with admixture prior to the dispersal of modern Han Chinese. Furthermore, contrary to a previous report, Neandertal ancestry does not explain a significant amount of heritability in depression. Our findings provide the largest genetic data set so far made available for Han Chinese and provide insights into the history and population structure of the world's largest ethnic group."
    Very interesting. I guess, I was right questioning the explanation behind "High Altitude (Tibetan) adaptation" of certain Denisovan alleles.
    Be wary of people who tend to glorify the past, underestimate presence, and demonize the future.

  3. #3
    Regular Member Achievements:
    1000 Experience PointsVeteran
    spruithean's Avatar
    Join Date
    29-08-12
    Posts
    65
    Points
    4,206
    Level
    18
    Points: 4,206, Level: 18
    Level completed: 89%, Points required for next Level: 44
    Overall activity: 7.0%

    Y-DNA haplogroup
    I-Y3647 (Y7198)
    MtDNA haplogroup
    HsomethinNetherlands

    Ethnic group
    Scottish, Irish, Welsh, English, French, Dutch (Frisian & Dutch), some German and Native American
    Country: Canada-Ontario





    Very interesting indeed. Hopefully more studies can be done on understudied populations.
    Y-DNA: I-Y3647 (Z140>F2642>CTS6772 (NEVGEN 100% score) Origin: Scotland
    mtDNA: Origin: Netherlands
    Heritage: Celto-Germanic with some Amerindian
    DNA tested in other lines: R-M222 (Ireland), R-S1141 (Scotland & Ireland), R-L21 (Ireland, Scotland), mt-J1c3 (Ireland), R-U106 (England), I-M223 (Ireland)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •