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Genes and mutations associated with neuropsychological conditions and disorders

If you tested your DNA with a personal genomics service like 23andMe, DeCODEme, FTDNA's Family Finder or another testing company, you can learn more about your risk factors for hundreds of diseases. Many of these SNP's are tested but not (yet) part of the report provided by personal genomics companies. This is free extra information.

We recommend that you install the SNPTips add-on for Mozilla Firefox to browse these pages. It allows you to upload your DNA results in the browser and show instantly which allele variant you have for each of the SNP listed below.

What can DNA tell you about yourself ?

List of neuropsychological conditions and disorders with associated genes and SNP's

Alleles : This list comprises positive, neutral and negative traits and conditions. Therefore we won't refer to risk factor like for diseases here. Correlated alleles can be either strongly associated (over 3x higher chances) or moderately associated (up to 3x higher chances) with each condition/trait.

In some cases the allele can be negatively correlated (lower chances). Depending on the testing company, sometimes A is reported as T, and G is reported as C, or vice-versa.

Testing companies :
A = 23andMe
(all versions) ; A2* = 23andMe (v2 only) ; A2 = 23andMe (v2 & v3) ; A3 = 23andMe (v3 only)
B = FamilyTreeDNA (FamilyFinder)
Bold letters indicate that the SNP is part of the official report, and is therefore likely to be more reliable. Only SNP's in the official report are listed for deCODEme.

Description Chromosome Gene SNP Alleles Tested by*
ADHD 3 SLC9A9 rs1242075 CC, CT, TT A3
3 HES1 rs4686673 AA, AG, GG A3
4 CLOCK rs1801260 AA, AG, GG A
4 DRD5 Dinucleotide repeat 148-bp allele
5 SLC1A3 rs2269272 A3
5 SLC6A3 (DAT1) rs27072 AA, AG, GG A
6 HTR1B rs6296 CC, CG, GG A
7 DDC rs11575454 CC, CG, GG
rs1466163 AA, AG, GG
9 DBH rs1611115 CC, CT, TT A
11 FADS2 rs518511 AA, AC, CC
11 DRD4 rs1800955 CC, CT, TT
VNTR 7-repeat
11 BDNF rs6265 AA, AG, GG A
12 NTF3 rs6332 AA, AG, GG A
12 TPH2 rs1386493 AA, AG, GG A
rs17110747 AA, AG, GG
rs1843809 AA, AC, CC A
13 HTR2A rs6314 AA, AG, GG A
16 SLC6A2 (NET) rs3785143 AA, AG, GG A
17 ARRB2 rs7208257 AA, AG, GG
17 PNMT rs200173 AA, AG, GG
17 5-HTT (SERT) rs25531 AA, AG, GG, A3
20 SNAP25 rs3746544 AA, AC, CC A
rs3787283 A3
rs363026 AA, AC, CC
rs6039806 AA, AC, CC, A3
22 ADRBK2 rs3730315 AA, AG, GG
Autism 1 PTGS2 rs2745557 AA, AG, GG A3
2 ITGA4 rs1143674 AA, AG, GG A3
3 HTR3C rs6766410 AA, AC, CC A, B
rs6807362 CC, CG, GG A3
5 5p15 rs10513025 CC, CT, TT A3
5 DRD1 rs265981 AA, AG, GG A
rs4532 CC, CT, TT A
rs686 AA, AG, GG A
7 MET rs1858830 CC, CG, GG A
7 DOCK4 rs2217262 AA AC, CC A, B
9 KDM4C rs722628 A, B
9 MAPKAP1 rs536861 -
11 CD44 rs2421826 CC, CT, TT A, B
11 LDLRAD3 rs1358054 -
12 PVRIG rs1445442 A
12 APPL2 rs2272495 CC, CT, TT A, B
22 SHANK3 rs397514705 CC, CT, TT
22 SHANK3 rs9616915 CC, CT, TT A3
Autism (social communication problem) 14 - rs2352908 -
Autism (social communication problem) 6 6p22 rs9257616 -
Autism (delayed onset of speech) 7 CNTNAP2 rs7794745 AA, AT, TT A
rs2710102 CC, CT, TT A
Autism (Asperger's syndrome) 1 DISC1 rs1322784 A3
5 APC rs1804197 AA, AC, CC A
rs2229992 CC, CT, TT A2*
rs42427 AA, AG, GG
rs459552 AA, AT, TT A
rs465899 AA, AG, GG A3
Anxiety 1 NGF rs6330 A
12 TPH2 rs4570625 GG, GT, TT A
rs4565946 A
Bipolar disorder 5 DAT
3 - rs6442925 CC, CT, TT A, B
4 - rs534654 CC, CT, TT A, B
6 FKBP5 rs7757037 AA, AG, GG A, B
12 CACNA1C rs1006737 AA, AG, GG A3
rs2159100 CC, CT, TT A, B
12 TPH2 rs4570625 GG, GT, TT A, B
rs11178997 AA, AT, TT A
rs17110563 CC, CT, TT A, B
12 CUX2 rs3847953 A
12 FAM109A rs933399 A, B
13 HTR2A
13 DGKH rs1012053 AA, AC, CC A
16 PALB2 rs420259 AA, AG, GG A
22 CSNK1E rs1534891 CC, CT, TT A, B
22 BCR rs140504 AA, AG, GG A
rs131690 AA, AG, GG A
rs131702 GG, GT, TT A3
Bipolar disorder (lithium treatment) 3 GADL1 rs17026688 T carriers respond better to lithium
rs17026651
Depression 1 MTHFR rs1801133 AA, AG, GG A
2 PDE11A rs3770018 AA, AC, CC
5 DAT
7 CHRM2 rs1824024 AA, AC, CC A
rs2061174 AA, AG, GG A
rs324650 AA, AT, TT A
11 BDNF rs6265 AA, AG, GG A
11 TPH1 rs1799913 GG, GT, TT A
rs7933505 AA, AG, GG A
13 HTR2A
17 SERT (5HTT)
21 PDE9A rs729861 CC, CT, TT
22 BCR rs3761418 AA, AG, GG A3
rs2267012 AA, AG, GG A3
rs2267013 AA, AG, GG A
rs2267015 AA, AT, TT
rs2156921 AA, AG, GG A
rs3313172 CC, CG, GG
Dyslexia 6 KIAA0319 rs761100 GG, GT, TT A
rs4504469 CC, CT, TT A
rs3212236 AA, AG, GG A
6 DCDC2 rs793862 AA, AG, GG A
rs807701 CC, CT, TT A
6 TTRAP rs2143340 CC, CT, TT A
Epilepsy 18 ME2 rs642698 AA, AC, CC A
Obsessive-Compulsive Disorder 3 DRD3 rs6280 CC, CT, TT A
11 ANKK1 rs1800497 AA, AG, GG A
12 TPH2 rs4570625 GG, GT, TT A
rs4565946 CC, CT, TT A
17 SERT (5HTT)
17 SLC6A4 rs25531 A3
rs25532 CC, CT, TT A3
22 COMT rs4680 AA, AG, GG A
Schizophrenia A DISC1 rs3738401 AA, AG, GG A
rs6675281 CC, CT, TT A
A CHI3L1 rs4950928 CC, CG, GG A
6 DTNBP1 rs760761 AA, AG, GG A
rs1018381 AA, AG, GG A
rs2619522 AA, AC, CC A
8 SLC18A1 rs2270641 GG, GT, TT
10 intergenic rs17101921 AA, AG, GG
13 HTR2A
11 DRD2 rs1801028 CC, CG, GG A
rs6277 CC, CT, TT A
11 TPH1 rs7933505 A
rs1800532 AA, AC, CC A
rs211105 A
11 intergenic rs10790212 CC, CT, TT A
11 intergenic rs497768 A
22 GNB1L rs2269726 CC, CT, TT A
22 COMT rs4680 AA, AG, GG A
rs737865 AA, AG, GG A
rs165599 AA, AG, GG A
X CSF2RA rs4129148 CC, CG, GG A
rs28694718 CC, CT, TT A
rs28414810 CC, CG, GG A2*
X IL3RA rs6422441 CC, CT, TT
rs6603272 GG, GT, TT A
rs17883192 CC, CG, GG A
Social Phobia A RGS2 rs4606 CC, CG, GG
17 SLC6A4 (SERT or 5HTT) rs140701 AA, AG, GG A
rs3794808 CC, CT, TT A
rs4583306 AA, AG, GG A
rs25531 A3


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