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Maciamo
26-08-11, 14:27
The HLA genes play a vital role in our immune system. HLA can confer you immunity against some diseases, but also make you more prone to some autoimmune reactions (check this thread (http://www.eupedia.com/forum/showthread.php?25151-HLA-types-and-autoimmune-diseases) to know more).

Nature (http://www.nature.com/news/2011/110809/full/476136a.html?WT.mc_id=TWT_NatureNews) and Science (http://www.sciencemag.org/content/early/2011/08/19/science.1209202.abstract) recently reported that Eurasian people inherited some of their HLA genes from Neanderthals and Denisovans. This includes HLA-A2, HLA-A11, HLA-A24, HLA-B7, HLA-B8, HLA-B15, HLA-B38, HLA-B39, HLA-B40, HLA-B44, HLA-B48, HLA-B51, HLA-B52, HLA-B66, HLA-B67, HLA-B73, HLA-Cw1, HLA-Cw2, HLA-Cw4, HLA-Cw7, HLA-Cw14, HLA-Cw15 and HLA-Cw16. You can read the details in the supporting material (http://www.sciencemag.org/content/suppl/2011/08/19/science.1209202.DC1/1209202-Abi-Rached.SOM.pdf).

HLA can also be used to determine one's ancestry. It doesn't work as well as Y-DNA because humans obviously need genetic diversity to survive and fight off diseases, which explains why some HLA type are found on several or all continents.

But within a continent, HLA can be useful in determining the degree of influence of one ethnic group between regions. For example, the study People of the British Isles (http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2011127a.html) published 2 weeks ago analysed some HLA types as well as Y-DNA haplogroups. Whereas many HLA types were evenly distributed, a few obviously correlated with the historical migration patterns in Britain. Based on the regional frequencies, it can be estimated that HLA-B8 correlates more strongly with a Celtic origin (other data indicate a peak of 17% in Ireland, Cornwall and Devon, then 12.5% in Belgium, then France, North Italy and North Spain). On the other hand, HLA-Cw3 appears to be more Germanic, with maximum frequencies in Britain reached in East England (17.5%) and Orkney (17.1%) and the lowest frequency in the Southwest (12.3%). Using the same logic, HLA-DRB4 is more Celtic, while HLA-DRB7 and HLA-DRB15 point rather at higher incidence among Germanic, and particularly Scandinavian, people.

Mzungu mchagga
26-08-11, 22:35
I don't fully understand. If I receive HLA genes from my parents, do I get it from just one part or do I inherit a sort of combination of both?
Is it that part of our genes that is associated with certain body fragrance which contributes to sexual attractiveness?

Maciamo
11-12-11, 13:32
I don't fully understand. If I receive HLA genes from my parents, do I get it from just one part or do I inherit a sort of combination of both?
Is it that part of our genes that is associated with certain body fragrance which contributes to sexual attractiveness?

Every person has two HLA-A, two HLA-B, two HLA-Cw... We inherit one of each from each parent.

guillem
19-06-18, 08:24
Je suis A*01,A*26,B*08,B*27,C*01,C*07,DRB1*07,DRB1*15
J'aimerai connaitre les sous catégories aussi. Je ne sais pas s'il existe des tests.

le site allelefrequencies permet de voir quelles populations on les même HLA que vous. En coordination avec la généalogie ça devient intéressant :
A*01 : Gitan (Andalusia, Czech) (j'ai des origines d' Al-Andalus)
A*26 : Gitan Tchèques (mon ancêtre Wilhem LAMAT viens de Bohème en 1400)
B*08 : UK, Irlande
B*27 : Gitan république tchèque
C*01 : Chine Wuhan (mon ancêtre Gan Ying)
C*07 : UK
DRB1*07 : Chine Shandong, Ibiza, Juifs de Mallorque, Minorque (Iles Baléares : je suis catalan de par mon père)
DRB1*15 : Birmanie, Malaisie (alors là je ne comprend pas encore)

gvia66
09-10-18, 07:48
Somone know a way to test the subtypes ?
Quelqu'un connait-il un service pour tester les soustypes ?