PDA

View Full Version : $1,000 genome soon available



Maciamo
15-01-14, 22:13
Quick news flash from the BBC: Science enters $1,000 genome era (http://www.bbc.co.uk/news/science-environment-25751958)


The ability to sequence a human genome for just $1,000 has arrived, a US genetic technology company has announced.

San Diego-based Illumina says it is to release a new sequencing machine that can deliver five whole genomes in a day.

The race to unlock a human's genetic blueprint for $1,000 has been underway for more than a decade.


Let's hope that 23andMe's confrontation with the FDA will soon be solved and that they will provide e $1,000 genome test soon enough.

adamo
15-01-14, 22:37
What does this test offer?

bicicleur
15-01-14, 23:51
you spit into some machine and it is going to print your DNA
no specialists needed any more to analyze your DNA
but how do you read the printout?
how do you translate the text into SNP's?

ebAmerican
15-01-14, 23:56
Your full genome.

If science can reduce a full genome scan to $1000 per person, it becomes more cost effective for private companies to afford full genome research projects. You need 1,000 samples at least to get a high confidence interval rate. Even at $1000 per person the study would cost 1 million. Before technology allowed cheaper genome sequencing it was way to expense and the risk to high to complete full genome comparison research. I'm very nervous in opening up this door. It screams abuse. Imagine if a pharmaceutical company conducted a research project and found that a particular DNA sequence gave a high confidence rate of 95% of longevity up to ones 90s, and an other study showing a high confidence rate for longevity into ones 50s. That information could be used to deny life insurance or medical insurance for the patient who is more prone to die in his 50s. The Pharmaceutical company would be obligated by regulatory enforcement to release it's studies if it pertained to a particular gene therapy drug. Insurance companies could get a hold of this information and require full genome test to qualify for coverage. It would look like the credit requirements for job applicants. New laws would need to be passed to ban companies from using genetic information as qualifiers.

adamo
16-01-14, 00:30
Mmmmmmm delish, only 1 grand $$$

LeBrok
16-01-14, 01:14
I'll do the full genome in 2016 when it is 300.00

adamo
16-01-14, 13:01
Exactly, I think I'll wait a few years lolll

John123
18-01-14, 03:32
How does the full genome test work? Can I see a demo? What information would it give? All lineages from all four grandparents how many generations back? I would like to be among the first to order this test to give you guys a heads up about the results and quality of the system, I just need guidance and information on it at this point.

John123
18-01-14, 04:30
How many lineages does this test discover and on what sides?

LeBrok
18-01-14, 04:40
How does the full genome test work? Can I see a demo? What information would it give? All lineages from all four grandparents how many generations back? I would like to be among the first to order this test to give you guys a heads up about the results and quality of the system, I just need guidance and information on it at this point.
Why don't you try and give us your experience and expertise on it. Otherwise how the hell do we know?!
At least instead of blabbing your mouth in useless manner, please take a bit of your time and investigate some info on involved websites, read up some information on this test and write a small informative article for us all here. It will be greatly appreciated and we'll gladly reward you with reputation points and a lot of nice words.
Is it too much to ask?

John123
18-01-14, 12:16
Would appreciate if someone could give me details bout what lineages this uncovers before I take the test; there's a lot of talking about having your full genome sequenced but not much info or description on what that means or what you'll get.

John123
19-01-14, 06:39
Would the full genome dwelve deep into your two "main" lineages or would it basically show you every lineage you belong to many generations back? I'm having a hard time grasping the concept of what it would do.

LeBrok
19-01-14, 09:58
Would the full genome dwelve deep into your two "main" lineages or would it basically show you every lineage you belong to many generations back? I'm having a hard time grasping the concept of what it would do.
It is same as with part of the genome we sequence right now. With full genome we'll have more details and more comprehensive research. With this and giving more time for a statistical research we will find out all genes responsible for diseases, predispositions and traits. Deep clades for everything, if you will.


would it basically show you every lineage you belong to many generations back?
No, it still will show you only direct lines of mtdna, and paternal Y. The rest of your ancestors will always get fussy connections, although it will improve with full genome, like percentages of Baltic, Mediterranean, EEF, WHG, etc admixtures, and resolution will improve as new admixtures will show up.

John123
19-01-14, 10:19
Wow. So basically it would just equate to digging deeper into my T and H markers without discovering anything else at all?

Maciamo
19-01-14, 13:30
What does this test offer?

There isn't any commercial test for the full genome yet. Illumina, the company that makes the DNA sequencer, only announced the sale of a new cheaper machine that will allow testing companies like 23andMe of FTDNA to offer full genomic sequence to their customers for as low as 1000$.

The full genomic sequence will allow to have an even better understanding of population genetics and medical conditions.

It's not clear from the announcement, but the full genome test should also make it possible to count the number of repeat alleles (e.g. short tandem repeats, aka STR), contrarily to SNP-based tests like 23andMe. Repeat alleles are essential for estimate risk factors for some diseases and especially psychological conditions such as ADHD, autism or schizophrenia. One famous example is the 7 repeat (7R) allele of the D4 Dopamine Receptor (DRD4), which has been associated (http://foodaddictionsummit.org/docs/6Noble.pdf) with much higher levels of novelty seeking behaviour.

And of course STR tests are also used frequently for Y-chromosomal testing (Y-DNA tests like those sold by FTDNA).

The full Y-DNA sequence alone makes it possible to draw a genealogical tree of humanity with an accuracy level of one generation (since even the Y chromosomes of a father and his son will be distinguishable by a few de novo mutations).

John123
19-01-14, 14:28
Oh ok so I totally misinterpreted, I bought this test would uncover like 15 new lineages in the past 10 generations; I guess I was wrong if I understood correctly.