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Plutocracy
20-08-15, 13:54
Hi all, I'm wondering why there are more scientific papers published on methylation over acetylation. On PubMed, there are 50k results when I type in "DNA methylation", but only 12k results when I type in "histone acetylation". Is there any clear reason why? Methylation being easier to assay, having more clinical importance, or being discovered earlier? Please let me know.

LeBrok
22-08-15, 00:14
Very good questions. I noticed that too and we need answers.
Does sequencing of Dna strips genes of these groups therefore can't tell us which gene is active or not?

Plutocracy
22-08-15, 06:41
I believe bisulfite sequencing helps for methylation, but more advanced protocols are needed for acetylation, using enzymes, RNA, or antibodies.