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View Full Version : HLA-DR9 : distribution map, subtypes, SNPs and associated medical conditions



Maciamo
29-01-16, 12:31
Here is a map showing the allele frequency of HLA-DR9 (http://en.wikipedia.org/wiki/HLA-DR7). It is overall an North Asian HLA type, although it is also found in Lebanon and the Maghreb (but Lebanese do have 1-2% of North Asian DNA associated with Y-DNA haplogroup Q1b). The maximum frequencies are observed among the Saami (7 to 16% depending on the sampling region), then in Volga-Ural ethnic groups such as the Mari (11.5%), Bashkirs (5%), Chuvash (5%) and Tatars (3.5%). In Asia, DR9 peaks in East Siberia (28%) but is also very common in China and Taiwan (10-15% depending on the region).

In eastern and northern Europe HLA-DR9 is strongly correlated with Y-haplogroups N1c (http://www.eupedia.com/europe/Haplogroup_N1c_Y-DNA.shtml) and Q1a (http://www.eupedia.com/europe/Haplogroup_Q_Y-DNA.shtml), and to a lower extent also with with East Asian admixture. This correlation diminishes as we move west and south, but is found at higher frequencies in region with more Nordic/Viking ancestry, including Northwest Iberia (Suebi). The Basques also have a bit more DR9 than the Spanish average and also happen to have 1% of Y-haplogroup Q, although it is unknown where this comes from.

http://cdn.eupedia.com/images/content/HLA-DR9.png (http://www.eupedia.com/genetics/HLA-DR_distribution_maps.shtml#DR9)


Medical associations

HLA-DR9 is associated with early childhood myastenia gravis.


SNP's

You can verify if you carry HLA-DR9 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. Almost all Europeans belong to the DRB1*09:01 subclade.

- DRB1*09:01 : rs2395185 (T), rs2516049 (C)

You normally need to be positive for both alleles.

Sile
29-01-16, 18:48
Here is a map showing the allele frequency of HLA-DR9 (http://en.wikipedia.org/wiki/HLA-DR7). It is overall an North Asian HLA type, although it is also found in Lebanon and the Maghreb (but Lebanese do have 1-2% of North Asian DNA associated with Y-DNA haplogroup Q1b). The maximum frequencies are observed among the Saami (7 to 16% depending on the sampling region), then in Volga-Ural ethnic groups such as the Mari (11.5%), Bashkirs (5%), Chuvash (5%) and Tatars (3.5%). In Asia, DR9 peaks in East Siberia (28%) but is also very common in China and Taiwan (10-15% depending on the region).

In eastern and northern Europe HLA-DR9 is strongly correlated with Y-haplogroups N1c (http://www.eupedia.com/europe/Haplogroup_N1c_Y-DNA.shtml) and Q1a (http://www.eupedia.com/europe/Haplogroup_Q_Y-DNA.shtml), and to a lower extent also with with East Asian admixture. This correlation diminishes as we move west and south, but is found at higher frequencies in region with more Nordic/Viking ancestry, including Northwest Iberia (Suebi). The Basques also have a bit more DR9 than the Spanish average and also happen to have 1% of Y-haplogroup Q, although it is unknown where this comes from.

http://cdn.eupedia.com/images/content/HLA-DR9.png (http://www.eupedia.com/genetics/HLA-DR_distribution_maps.shtml#DR9)


Medical associations

HLA-DR9 is associated with early childhood myastenia gravis.


SNP's

You can verify if you carry HLA-DR9 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. Almost all Europeans belong to the DRB1*09:01 subclade.

- DRB1*09:01 : rs2395185 (T), rs2516049 (C)

You normally need to be positive for both alleles.





rs2395185 (https://www.23andme.com/you/explorer/snp/?snp_name=rs2395185)
G or T
GG
Andrew


GT
Lucien


GT
victor







rs2516049 (https://www.23andme.com/you/explorer/snp/?snp_name=rs2516049)
C or T
TT
Andrew


CT
Lucien


CT
victor