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View Full Version : HLA-DR13 : distribution map, subtypes, SNPs and associated medical conditions



Maciamo
29-01-16, 14:44
Here is a map showing the allele frequency of HLA-DR13 (http://en.wikipedia.org/wiki/HLA-DR13). Unlikely most other HLA types, DR13 does not show any specific geographic pattern or associated with ethnic groups or Y-DNA haplogroup. This is because DR13 is in fact divided in three major subclades and patterns are only meaningful within each subclade.

Except for Sardinia which has a bit under 1% of DR13, all countries in Europe, North Africa and the Middle East have between 5 and 15% of this HLA type. Worldwide, DR13 is most common in the Sahel region, in Ethiopia and in India, but is is found on all continent, probably because it is efficient in fighting many infections, but also because of virtually no autoimmune condition is linked to it, contrarily to most other HLA-DR types.


http://cdn.eupedia.com/images/content/HLA-DR13.png (http://www.eupedia.com/genetics/HLA-DR_distribution_maps.shtml#DR13)


Subclades

Over 200 subclades of DR13 exist, but only three have frequencies high enough to be meaningful. Note that many countries in eastern Europe and the Balkans did not test for DR13 subclades and therefore could not be included in the statistics.

- DRB1*13:01 : very wide distribution from South Africa to Siberia via Europe and the Middle East. Around Europe, it peaks in Georgia (12.5%), the Netherlands (10.5%), the Basque country and northern Catalonia (10%), Portugal (9%), Finland (9%), Swedish Saami (9%), Denmark (8.5%), Norway (8%), Germany (8%), Belgium (7.5%), Switzerland (7.5%), Spain (7.5%), Austria (7%), the Czech Republic (7%) and Poland (7%).

- DRB1*13:02 : Peaks in Saudi Arabia (20%), Ethiopia (17%), Congo and Rwanda (14%), Morocco (10%), South Korea (9%), and Japan (8%). In Europe, it is highest in the Netherlands (6%), Denmark (5.5%), Germany (5%), Austria (5%), Switzerland (5%), Norway (5%), Spain (5%), France (4.5%), Portugal (4.5%), Britain (4.5%), etc. It is found mostly in western Europe, in former Hallstatt Celtic and Germanic countries.

- DRB1*13:03 : Very wide distribution. A few isolated peaks between 5 and 10% in central Africa, Ethiopia, Tunisia, Palestine, Lebanon, Northeast India and parts of China. It is much rarer in Europe. It is only found above 1% in Pyrenean Spain (4-8%), South Portugal (4%), the Czech Republic (3.5%), Poland (2%), Southeast France (2%), Switzerland (1.5%), Austria (1.5%), Italy (1.5%), Slovenia (1.5%), Greece (1.5%). So mostly in mountainous regions and especially around the Alps.


Medical associations

HLA-DR13 is associated with early childhood myastenia gravis.

Being DR13 increases the efficacy of immunization for hepatitis B and C.


SNP's

You can verify if you carry HLA-DR13 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder.

- DRB1*13:01 : rs2395173 (A), rs2157051 (C)
- DRB1*13:02 : rs4434496 (T), rs6901541 (C)
- DRB1*13:03 : rs424232 (T), rs2050191 (A)

You need to be positive for both alleles in one subclade.

Sile
29-01-16, 18:52
Here is a map showing the allele frequency of HLA-DR13 (http://en.wikipedia.org/wiki/HLA-DR13). Unlikely most other HLA types, DR13 does not show any specific geographic pattern or associated with ethnic groups or Y-DNA haplogroup. This is because DR13 is in fact divided in three major subclades and patterns are only meaningful within each subclade.

Except for Sardinia which has a bit under 1% of DR13, all countries in Europe, North Africa and the Middle East have between 5 and 15% of this HLA type. Worldwide, DR13 is most common in the Sahel region, in Ethiopia and in India, but is is found on all continent, probably because it is efficient in fighting many infections, but also because of virtually no autoimmune condition is linked to it, contrarily to most other HLA-DR types.


http://cdn.eupedia.com/images/content/HLA-DR13.png (http://www.eupedia.com/genetics/HLA-DR_distribution_maps.shtml#DR13)


Subclades

Over 200 subclades of DR13 exist, but only three have frequencies high enough to be meaningful. Note that many countries in eastern Europe and the Balkans did not test for DR13 subclades and therefore could not be included in the statistics.

- DRB1*13:01 : very wide distribution from South Africa to Siberia via Europe and the Middle East. Around Europe, it peaks in Georgia (12.5%), the Netherlands (10.5%), the Basque country and northern Catalonia (10%), Portugal (9%), Finland (9%), Swedish Saami (9%), Denmark (8.5%), Norway (8%), Germany (8%), Belgium (7.5%), Switzerland (7.5%), Spain (7.5%), Austria (7%), the Czech Republic (7%) and Poland (7%).

- DRB1*13:02 : Peaks in Saudi Arabia (20%), Ethiopia (17%), Congo and Rwanda (14%), Morocco (10%), South Korea (9%), and Japan (8%). In Europe, it is highest in the Netherlands (6%), Denmark (5.5%), Germany (5%), Austria (5%), Switzerland (5%), Norway (5%), Spain (5%), France (4.5%), Portugal (4.5%), Britain (4.5%), etc. It is found mostly in western Europe, in former Hallstatt Celtic and Germanic countries.

- DRB1*13:03 : Very wide distribution. A few isolated peaks between 5 and 10% in central Africa, Ethiopia, Tunisia, Palestine, Lebanon, Northeast India and parts of China. It is much rarer in Europe. It is only found above 1% in Pyrenean Spain (4-8%), South Portugal (4%), the Czech Republic (3.5%), Poland (2%), Southeast France (2%), Switzerland (1.5%), Austria (1.5%), Italy (1.5%), Slovenia (1.5%), Greece (1.5%). So mostly in mountainous regions and especially around the Alps.


Medical associations

HLA-DR13 is associated with early childhood myastenia gravis.

Being DR13 increases the efficacy of immunization for hepatitis B and C.


SNP's

You can verify if you carry HLA-DR13 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder.

- DRB1*13:01 : rs2395173 (A), rs2157051 (C)
- DRB1*13:02 : rs4434496 (T), rs6901541 (C)
- DRB1*13:03 : rs424232 (T), rs2050191 (A)

You need to be positive for both alleles in one subclade.






rs4434496 (https://www.23andme.com/you/explorer/snp/?snp_name=rs4434496)
C or T
CT
Andrew


CT
Lucien


CT
victor







rs6901541 (https://www.23andme.com/you/explorer/snp/?snp_name=rs6901541)
C or T
CT

Andrew


CT
Lucien


CT
victor