PDA

View Full Version : HLA-DR10 : distribution map, subtypes, SNPs and associated medical conditions



Maciamo
02-02-16, 11:34
Here is a map showing the allele frequency of HLA-DR10 (http://en.wikipedia.org/wiki/HLA-DR10). The maximum frequencies are observed in the Lebanon (5.2%), Saudi Arabia (4.8%), Palestine (4.7%), Jordan (3.8%), Morocco (3.3%), Algeria (3%), Tunisia (3%), and oddly enough also among the Saami people (2.9%). It is absent from the Basque population and nearly absent from Sardinia and Brittany. You can visualise the data by country on this table of HLA-DR frequencies (http://www.eupedia.com/genetics/HLA-DR_allele_frequencies_by_country.shtml).

Worldwide, the highest frequencies are observed in Africa (9% in Sudan and Burkina Faso, 6% in Mozambique) and in South Asia (typically above 5%) and especially in South India (10 to 21%). In Europe, the Gypsies also have higher frequencies (about 4%).


http://cdn.eupedia.com/images/content/HLA-DR10.png (http://www.eupedia.com/genetics/HLA-DR_distribution_maps.shtml#DR10)

The distribution suggests a strong Southwest Asian and North African association. However its absence from Sardinia and the Basque country cannot link it to the Neolithic diffusion. Actually the closest association with Y-DNA haplogroups appears to be with E-M34 (http://www.eupedia.com/europe/Haplogroup_E1b1b_Y-DNA.shtml#M123) and J1-P58 (http://www.eupedia.com/europe/Haplogroup_J1_Y-DNA.shtml). Apart from being the two main Semitic paternal lineages, they are also found among the Greeks and Italians are reasonably high frequencies, which means that they (and HLA-DR10) would have spread around the Roman Empire, which pretty much matches the higher frequencies on the map.

Volga-Uralic people also carry DR10 and frequencies around 1.5%, with a peak of 3% among northern Swedish Saami. So DR10 seem to have two distinct origins: a Southwest Asian one and a Siberian one.


Medical associations

DRB1*1001 is associated with ovarian cancer (https://en.wikipedia.org/wiki/Ovarian_cancer) and invasive squamous cell cervical cancer (https://en.wikipedia.org/wiki/Cervical_cancer).

The DRB1*1001 : DQA1*01 : DQB1*05 haplotype is linked with rheumatoid arthritis.


SNP's

You can verify if you carry HLA-DR10 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. There are a dozen known subclades, but only DRB1*10:01 is common.

- DRB1*10:01 : rs4148871 (A), rs2071538 (A)

You normally need to be positive for both alleles.

Sile
03-02-16, 06:14
Here is a map showing the allele frequency of HLA-DR10 (http://en.wikipedia.org/wiki/HLA-DR10). The maximum frequencies are observed in the Lebanon (5.2%), Saudi Arabia (4.8%), Palestine (4.7%), Jordan (3.8%), Morocco (3.3%), Algeria (3%), Tunisia (3%), and oddly enough also among the Saami people (2.9%). It is absent from the Basque population and nearly absent from Sardinia and Brittany. You can visualise the data by country on this table of HLA-DR frequencies (http://www.eupedia.com/genetics/HLA-DR_allele_frequencies_by_country.shtml).

Worldwide, the highest frequencies are observed in Africa (9% in Sudan and Burkina Faso, 6% in Mozambique) and in South Asia (typically above 5%) and especially in South India (10 to 21%). In Europe, the Gypsies also have higher frequencies (about 4%).


http://cdn.eupedia.com/images/content/HLA-DR10.png (http://www.eupedia.com/genetics/HLA-DR_distribution_maps.shtml#DR10)

The distribution suggests a strong Southwest Asian and North African association. However its absence from Sardinia and the Basque country cannot link it to the Neolithic diffusion. Actually the closest association with Y-DNA haplogroups appears to be with E-M34 (http://www.eupedia.com/europe/Haplogroup_E1b1b_Y-DNA.shtml#M123) and J1-P58 (http://www.eupedia.com/europe/Haplogroup_J1_Y-DNA.shtml). Apart from being the two main Semitic paternal lineages, they are also found among the Greeks and Italians are reasonably high frequencies, which means that they (and HLA-DR10) would have spread around the Roman Empire, which pretty much matches the higher frequencies on the map.

Volga-Uralic people also carry DR10 and frequencies around 1.5%, with a peak of 3% among northern Swedish Saami. So DR10 seem to have two distinct origins: a Southwest Asian one and a Siberian one.


Medical associations

DRB1*1001 is associated with ovarian cancer (https://en.wikipedia.org/wiki/Ovarian_cancer) and invasive squamous cell cervical cancer (https://en.wikipedia.org/wiki/Cervical_cancer).

The DRB1*1001 : DQA1*01 : DQB1*05 haplotype is linked with rheumatoid arthritis.


SNP's

You can verify if you carry HLA-DR10 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. There are a dozen known subclades, but only DRB1*10:01 is common.

- DRB1*10:01 : rs4148871 (A), rs2071538 (A)

You normally need to be positive for both alleles.



as for my family

all negatives for both except son is AA for rs2071538

PaschalisB
11-02-16, 19:50
Is there going to be a map of HLA-DR14 distribution?