View Full Version : Redheads need more anesthesia to go under?

21-09-16, 15:10
I put this as a question mark because I'm not so sure about this...They're going to draw these kinds of conclusions from a sample of 20, all of them from one American towns?


": The desflurane requirement in redheads (6.2 volume-percent [95% CI, 5.9 - 6.5]) was significantly greater than in dark-haired women (5.2 volume-percent [4.9 – 5.5], P = 0.0004). Nine of 10 redheads were either homozygous or compound heterozygotes for mutations on the melanocortin-1 receptor gene.Conclusions: Red hair appears to be a distinct phenotype linked to anesthetic requirement in humans that can also be traced to a specific genotype."

03-01-17, 13:40
I am still waiting to see a larger study, but there are quite a few more with more participants all indicating the same. Some indicating significant differences.

Here are a couple:

"Increased Sensitivity to Thermal Pain and Reduced Subcutaneous Lidocaine Efficacy in Redheads"


"We evaluated pain sensitivity in red-haired (n=30) or dark-haired (n=30) women"


"Red hair is the phenotype for mutations of the melanocortin 1 receptor. Our results indicate that redheads are more sensitive to thermal pain and are resistant to the analgesic effects of subcutaneous lidocaine. Mutations of the melanocortin 1 receptor, or a consequence thereof, thus modulate pain sensitivity."

"Genetic variations associated with red hair color and fear of dental pain, anxiety regarding dental care and avoidance of dental care."


"The authors enrolled 144 participants (67 natural red-haired and 77 dark-haired) aged 18 to 41 years in a cross-sectional observational study."


"Dentists should evaluate all patients, but especially those with naturally red hair, for dental care-related anxiety and use appropriate modalities to manage the patients' anxiety."

"Anesthetic efficacy of the inferior alveolar nerve block in red-haired women."


"One-hundred twenty-four adult female subjects (62 red haired and 62 dark haired) participated in this study."


"Red hair and the MC1R gene were significantly linked to higher levels of dental anxiety but were unrelated to success rates of the IAN block in women with healthy pulps."