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Aha
18-12-16, 00:03
I am looking for the best DNA test kid deal on the market today (or in few weeks)

I need it for:
1) Y-DNA with the deepest subclades/snp possible;
2) Autosomal DNA data - I want to use that to calculate my hunter gatherer and other admixtures. Finding matches on FTDNA seems a very nice addition too, but major purpose is the detailed genetic admixture picture;
3) mtDNA
Budget is not unlimited
I researched the topic a year ago and my best option so far was Geno 2.0 NextGen with a consequential transfer of the sample to FTDNA, where I order another Autosomal test (right? or I don't need it for the admixture calculator?).

What is the latest situation and the best deal on the market today?

Thank you!

bobbyau
04-01-17, 03:11
Perhaps LivingDNA at 159 euros I think it is..

they test...

650,000 autosomal DNA SNPs
20,000 Y-DNA SNPs
4,000 MT-DNA SNPs.

Maciamo
04-01-17, 18:25
My ranking would be as follow:

1) LivingDNA
2) Geno 2.0.
3) 23andMe (for those who care less about deep haplogroup clades and more about health reports)

Sile
04-01-17, 22:34
I am looking for the best DNA test kid deal on the market today (or in few weeks)

I need it for:
1) Y-DNA with the deepest subclades/snp possible;
2) Autosomal DNA data - I want to use that to calculate my hunter gatherer and other admixtures. Finding matches on FTDNA seems a very nice addition too, but major purpose is the detailed genetic admixture picture;
3) mtDNA
Budget is not unlimited
I researched the topic a year ago and my best option so far was Geno 2.0 NextGen with a consequential transfer of the sample to FTDNA, where I order another Autosomal test (right? or I don't need it for the admixture calculator?).

What is the latest situation and the best deal on the market today?

Thank you!

my sister did Geno 2.0 NextGen in November 2016 with her mtdna as H95a ( which is correct )............the transfer to ftdna gave her H-159c and nothing else, she needs to pay $39 to get a marking which will be better than what ftdna gave her but will not be the correct H95a as ftdna do not have it


nat geno 2 next gen gave her this ancestry for what its worth



40% Southern Europe

30% Western and Central Europe

16% Eastern Europe

12% Asia Minor

2% Jewish Diaspora


the only place I have jewish in my chromsome is in the X chromosome ............which is maternal

Maciamo
18-03-17, 09:53
I have now compiled a comprehensive DNA testing FAQ (http://www.eupedia.com/europe/dna_project_faq.shtml) to learn how to retrace ancestry with DNA, which test to choose and how to interpret your results.

raspberry
18-03-17, 17:24
I would like to do (and recommend) the " YSEQ's Whole Genome Test (15x)" (http://yseq.net/).
From their site: "​This WGS test is specifically designed for genealogy researchers and includes:


Full Mitochondrial Genome (Fasta file & haplogroup)
Annotation of all Y-SNP names and Y haplogroup information from Ybrowse.org (http://ybrowse.org/)
Separate VCF files for derived and novel Y-SNPs
User friendly autosomal allele files that can be immediately uploaded to genealogy tools like GedMatch (http://www.gedmatch.com/) (they will convert it even to 23andme format)
All raw data (FastQ, BAM, VCF etc.) supplied for free download or on SD card by mail
FREE Sanger sequencing confirmation of up to 10 novel Y-SNPs (for well prepared submission to the ISOGG tree)
Turn around time less than 3 months (after sample arrival)

In other words: This is the ultimate Y-DNA / mtDNA / Autosomal DNA Test in one package!"
The Price is 899$.

Maciamo
18-03-17, 20:48
I would like to do (and recommend) the " YSEQ's Whole Genome Test (15x)" (http://yseq.net/).
From their site: "​This WGS test is specifically designed for genealogy researchers and includes:


Full Mitochondrial Genome (Fasta file & haplogroup)
Annotation of all Y-SNP names and Y haplogroup information from Ybrowse.org (http://ybrowse.org/)
Separate VCF files for derived and novel Y-SNPs
User friendly autosomal allele files that can be immediately uploaded to genealogy tools like GedMatch (http://www.gedmatch.com/) (they will convert it even to 23andme format)
All raw data (FastQ, BAM, VCF etc.) supplied for free download or on SD card by mail
FREE Sanger sequencing confirmation of up to 10 novel Y-SNPs (for well prepared submission to the ISOGG tree)
Turn around time less than 3 months (after sample arrival)

In other words: This is the ultimate Y-DNA / mtDNA / Autosomal DNA Test in one package!"
The Price is 899$.

Sounds good. But they don't mention how many SNPs are tested. "Whole genome" can be misleading as they may just mean that they cover every gene of each chromosome (full or partial exome), but not necessarily all the 3 billion base pairs. In fact they say that the test cover "only" 42,000 single Y-SNPs , which may sound like a lot but is much less than then 20+ millions tested by FGC's Y Elite 2.1, and a far cry from the whole Y chromosome (59 million SNPs). So that must be true for all chromosomes.

raspberry
18-03-17, 22:26
Sounds good. But they don't mention how many SNPs are tested. "Whole genome" can be misleading as they may just mean that they cover every gene of each chromosome (full or partial exome), but not necessarily all the 3 billion base pairs. In fact they say that the test cover "only" 42,000 single Y-SNPs , which may sound like a lot but is much less than then 20+ millions tested by FGC's Y Elite 2.1, and a far cry from the whole Y chromosome (59 million SNPs). So that must be true for all chromosomes.
"Over 42,000 single Y-SNPs are available in our catalog and the portfolio is growing every day."- this does not belong to the Whole Genome sequencing. It just reffers to the rest of the site. Because they also offer single SNP testings and you can even wish any SNP for just 1$ (this is why they say "growing every day"). The Y-dna analysis of yseq is compareable to the "Genome Guide 15x Whole Genome" from the "Full Genome" site for 795$, but this does not even include an autosomal analysis. So this still seems to be very a good offer.
"YSEQ extracts the DNA in-house and performs a quality assurance test which includes quantification and a YSEQ Alpha Y-STR profile (or HVR1 mtDNA for females) to make sure the correct sample is handled. After QC (quality control) we send the sample to our partner laboratory, Macrogen, for NG sequencing on their HiSeq X-Ten platform. After the raw FastQ files are returned, YSEQ will perform an in depth analysis of the dataset focusing on genealogy relevant topics. We'll annotate every named Y-chromosome SNP from Ybrowse to a VCF document with their ancestral and derived states. You'll receive separate files for your derived SNPs and for your novel SNP candidates and the InDel mutations. The novel SNPs will be qualified by an experienced scientist manually and up to 10 novel mutations will be verified with your sample by Sanger sequencing (included in the price).

The analysis includes the complete mitochondrial DNA sequence with your mt haplogroup information. We also export the autosomal alleles in a 23andMe compatible format which can be used for many genealogy tools."

Maciamo
18-03-17, 23:53
"Over 42,000 single Y-SNPs are available in our catalog and the portfolio is growing every day."- this does not belong to the Whole Genome sequencing. It just reffers to the rest of the site. Because they also offer single SNP testings and you can even wish any SNP for just 1$ (this is why they say "growing every day"). The Y-dna analysis of yseq is compareable to the "Genome Guide 15x Whole Genome" from the "Full Genome" site for 795$, but this does not even include an autosomal analysis. So this still seems to be very a good offer.
"YSEQ extracts the DNA in-house and performs a quality assurance test which includes quantification and a YSEQ Alpha Y-STR profile (or HVR1 mtDNA for females) to make sure the correct sample is handled. After QC (quality control) we send the sample to our partner laboratory, Macrogen, for NG sequencing on their HiSeq X-Ten platform. After the raw FastQ files are returned, YSEQ will perform an in depth analysis of the dataset focusing on genealogy relevant topics. We'll annotate every named Y-chromosome SNP from Ybrowse to a VCF document with their ancestral and derived states. You'll receive separate files for your derived SNPs and for your novel SNP candidates and the InDel mutations. The novel SNPs will be qualified by an experienced scientist manually and up to 10 novel mutations will be verified with your sample by Sanger sequencing (included in the price).

The analysis includes the complete mitochondrial DNA sequence with your mt haplogroup information. We also export the autosomal alleles in a 23andMe compatible format which can be used for many genealogy tools."



The full mtDNA sequence is not much, only 16,500 SNPs. I still want to know how much SNPs are tested for 795$.

Hauteville
19-03-17, 00:06
Many peoples talked to me about new LivingDNA tool that according to them is economic and very good for ancestry composition and haplogroups. I'll try this in the next times.

Maciamo
23-03-17, 13:59
Here is a summary table of the DNA tests available in 2017.

SNPs included



Company
Autosomal SNP's
Y-DNA SNP's
X-DNA SNP's
mtDNA SNP's
Health SNPs


23andMe (v4)
577,382
2,329
19,487
3,154
yes


AncestryDNA
682,549
885
none
none
yes


Chromo 2.0
290,169
14,497
none
3,142
no


FTDNA Family Finder
690,000
none
none
none
no


FTDNA Comprehensive Genome
690,000
none (111 Y-STR)
none
16,569
no


Geno 2.0 NextGen
700,000
~20,000
yes
~4,000
no


Living DNA
638,000
22,500
17,800
4,700
yes


MyHeritageDNA
?
none
none
none
?




Prices, shipping costs & availabilities



Company
Price (USA/EU/UK)
Shipping fees
Countries available


23andMe
99~199$/169€/129£
9.95$ (US), 9.99£ (UK), 9.99€ (some EU), 40-72$ (other)
over 50 countries


AncestryDNA
99$/99€/79£
20$/€/£
35 countries


BritainsDNA Chromo 2.0
345$/285€/240£
free
worldwide


FTDNA Family Finder
79$
9.95$
worldwide


FTDNA Comprehensive Genome
546$
9.95$
worldwide


Geno 2.0 NextGen
149.95$
9.95$ (US), 19.95$ (Canada), 29.95$ (other countries)
worldwide


Living DNA
159$/159€/120£
free
worldwide


MyHeritageDNA
79$/79€/69£
12$/€/£
worldwide




Rating



Company
Autosomal report
Y-DNA haplogroup
mtDNA haplogroup
Value for money
Overall rating


1. Living DNA
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2. 23andMe (US, UK, North EU)*
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3. Chromo 2.0 (BritainsDNA)
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4. Geno 2.0 NextGen
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5. 23andMe (other countries)*
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6. Comprehensive Genome (FTDNA)
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7. MyHeritageDNA
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8. AncestryDNA
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9. Family Finder (FTDNA)
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You will find detailed explanations here (http://www.eupedia.com/europe/dna_project_faq.shtml#Company).

Sennevini
23-03-17, 17:55
That's a clear overview. I decided I can't wait any longer; it is all very cheap now compared to the past, and ordered a kit at Living DNA. I am very curious about all results. Now I'll have to wait and wait..

Tomenable
23-03-17, 20:06
Here is a summary table of the DNA tests available in 2017.

I was thinking about ordering 23andMe, but I will probably order Living DNA after reading your review.

I can also try to get tested for free because there is currently an ongoing project "Genomic Map of Poland":

https://www.put.poznan.pl/cn/node/994

They are going to test from 5,000 to 10,000 people from all over Poland. Would be nice to be among them.

Sile
23-03-17, 21:08
my sister did Geno 2.0 NextGen in November 2016 with her mtdna as H95a ( which is correct )............the transfer to ftdna gave her H-159c and nothing else, she needs to pay $39 to get a marking which will be better than what ftdna gave her but will not be the correct H95a as ftdna do not have it


nat geno 2 next gen gave her this ancestry for what its worth



40% Southern Europe
30% Western and Central Europe
16% Eastern Europe
12% Asia Minor
2% Jewish Diaspora


the only place I have jewish in my chromsome is in the X chromosome ............which is maternal



As of 23 March, Ftdna has upgraded the mtdna tree for me and sister.........we are correctly marked as H95a. the MyOrigins difference between myself ( old ftdna member ) and my sister , recent transfer to ftdna from Nat geno is about 10%.............it does not look like my sister is on the "beta" new myOrigins

Tomenable
23-03-17, 22:36
There are some problems with Living DNA, it does not tell you about your deep ancestry:

http://www.yourgeneticgenealogist.com/2017/02/the-new-living-dna-test-review-of-my.html

"(...) Reportedly, this test is only looking back to where your ancestors were about four to five generations ago, but the What you are made of section on the site states, "A typical profile provides your genetic ancestry going back about six generations." Either way, this is not a deep ancestry analysis and should reflect what we know about our recent ancestors. (...)"

Going only 4-6 generations back is not much. I already know all of this based on genealogy.

I want something which tells me about deep ancestry, at least hundreds of years back. It also seems that Living DNA is mostly catering to people with British ancestry. It even divides British ancestry into tiny regional "sub-admixtures".

Sennevini
23-03-17, 23:38
I see, livingdna seems to favour the British. I think they may skew some Dutch ancestry towards Anglo-Saxon. Their Y-dna and mt-DNA seem good enough at least.
I might also try 23andme later, but one at the time!

Maciamo
23-03-17, 23:54
There are some problems with Living DNA, it does not tell you about your deep ancestry:

http://www.yourgeneticgenealogist.com/2017/02/the-new-living-dna-test-review-of-my.html

"(...) Reportedly, this test is only looking back to where your ancestors were about four to five generations ago, but the What you are made of section on the site states, "A typical profile provides your genetic ancestry going back about six generations." Either way, this is not a deep ancestry analysis and should reflect what we know about our recent ancestors. (...)"

Going only 4-6 generations back is not much. I already know all of this based on genealogy.

I want something which tells me about deep ancestry, at least hundreds of years back. It also seems that Living DNA is mostly catering to people with British ancestry. It even divides British ancestry into tiny regional "sub-admixtures".

It is doubtful that the reports only goes back 4 to 6 generations. That's barely 100 to 200 years ago. I am still awaiting my results, but I know British people who tested and got their ancestral region or adjacent region rightly pinpointed, although with a percentage of 40 to 60%, which implies that they are going back much further (or aren't as accurate as they should be). Those Brits got about 5% of Scandinavian, about the same as with 23andMe. Such a figure would included Viking but not Anglo-Saxon ancestry, which makes sense since the Anglo-Saxons aren't really Scandinavian (Lower Jutland, Lower Saxony and Frisia). The Italian (Tuscan, so probably Roman) percentages were considerably higher with LivingDNA (5-10%) than with 23andMe (0-1%) in England.

DNA testing companies may not be the best judges of their own product. 23andMe claims that their Ancestry Composition goes back maximum 500 years, but in fact it is more 1000 to 2000 years.