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Angela
23-03-17, 20:10
Do people who have tested with 23andme find that their "traits" results are accurate?

LeBrok
23-03-17, 22:27
Pretty much mine are, except predicted "most likely curly hair", which is not right.

Sile
24-03-17, 07:10
more wrong than right

Maciamo
24-03-17, 09:47
Everything was correct for me.

Regio X
24-03-17, 16:12
In my case, more right than wrong. They missed just my mother's eyes and hair color, mine too, and my father's hair texture and freckling.
Gedmatch missed the eyes color of we all.

Angela
24-03-17, 16:12
Mine are more or less correct as well. The pigmentation ones are totally correct: dark hair, brown eyes, very fair skin. They also got it right that I'm taller and and thinner than the average woman. They got my hair texture wrong too, LeBroc, or I don't understand their definition of "curly" hair. They say I have straight or wavy hair, and while it's wavy now, I would say it was curly when I was a child. Maybe they're talking about non-European curly for very curly, for example?

They did get it right that I was born with absolutely no hair on my head. My father used to say it looked like an egg! My daughter was the same. Fortunately, nowadays we have stick on bows. :) My son was born with a full head of shiny black hair, so I thought he'd have hair like his father. Instead, although it never fell out as is usually the case with babies, it inexplicably and strangely turned pale blonde, a color he kept till his teens. I've never figured that one out.

There are only three others that are questionable, but the algorithm is probably right about two of them, and I was interpreting the symptoms incorrectly. One is that it says I don't get the alcohol flush reaction. I used to get what I thought was the alcohol flush reaction but then realized it mostly happens after I drink more than a glass of wine. Hard alcohol doesn't seem to cause it, although I still don't like the other consequences. I think it might be the preservatives they put in wine. The other is that it says I'm lactose tolerant, and I've had problems with too much dairy starting in my 30s. I checked the snps, though, and I have both copies, so I think there's something else going on.

The third one is toe length, although it's only a slight difference. They say my big toe is larger. Actually, my big toe and the second one are the same length, so I definitely have some of that Greek and Roman toes thing.
"Scientific studies of toe length ratio first appeared in the late 19th century when British anthropologists wondered why ancient Greek and Roman statues had longer second toes than big toes."

Oh, and they're right: no cleft chin, no dimples, no widow's peak, although I had a very slight one when I was younger, I think. I don't have a unibrow either. I do wish they were thicker, though; you can always pluck the middle part.

We talked about cleft chins here once. This is what they have to say: "It is commonly thought that cleft chins result from an incomplete fusion of the bones of the jaw during fetal development. While cleft chin is not a simple dominant or recessive trait, it does tend to run in families. Some scientists think humans evolved a prominent chin to cope with increased stress on the jaw. Others theorize that the trait contributed to sexual attractiveness. It's also possible that it evolved for no reason at all."

All in all I think they did a very good job, which leads me to think that the disease probabilities are probably in the ball park as well.

@RegioX,
That's odd about the eye color. I thought that you either have the blue eye gene or you don't.

Regio X
24-03-17, 17:22
@RegioX,
That's odd about the eye color. I thought that you either have the blue eye gene or you don't.Yes, it is, but we three don't have blue. The changes were brown to green and green to brown. In one case, perhaps it has something to do with a bit of yellow around the pupils.

Sile
25-03-17, 01:25
They state black hair and I was born blond , it became mid brown as a teenager .....................my father and grandfather and one son has black hair

They state blue eyes and I have mid-green eyes ............my father and grandfather had light-green eyes ............all my sons though have mid-blue eyes

They state blood type A- ............I was tested again recently .......I have A+ ...........all sons and their mother has A-

Fire Haired14
25-03-17, 01:55
Predicted Reality
Can Taste Bitter Compounds Probably
Prefer Savory over Sweet Snacks Correct
No Cleft Chin Correct
No Dimples Correct
No Unibrow Correct
No Widow's Peak Incorrect
Light Eyes Correct
Detached Earlobe Correct
Dark Hair Incorrect
Straight Hair Correct
Little Upper Back Hair Correct
Longer Ring than Index Finder Correct
Tan Skin Incorrect
No Freckles Correct
Lactose TolerantCorrect
Little Caffine Consumption Incorrect
Not a Deep SleeperCorrect
SprinterCorrect
Moves a lot in Sleep Incorrect

Regio X
25-03-17, 03:00
They state black hair and I was born blond , it became mid brown as a teenager .....................my father and grandfather and one son has black hair

They state blue eyes and I have mid-green eyes ............my father and grandfather had light-green eyes ............all my sons though have mid-blue eyes

They state blood type A- ............I was tested again recently .......I have A+ ...........all sons and their mother has A-I forgot to mention they also missed my father's hair color, which was not light when he was young. My mother, on the contrary, had light, and they stated dark.

Maciamo
25-03-17, 09:09
Yes, it is, but we three don't have blue. The changes were brown to green and green to brown. In one case, perhaps it has something to do with a bit of yellow around the pupils.

The report only distinguishes between blue and brown eyes. They don't make any predictions on green, hazel or mixed colours (like a yellow ring around the pupil, which is very common among blue eyed people). There is another (preliminary) report on eye colour that attempts to give odds of having green rather than blue eyes, but 23andMe doesn't make predictions on that because they probably know that there are more, yet unidentified SNPs involved. So I cannot see how you could say that they got it wrong if the eye colour in question involves green or hazel (green-yellow-brown) eyes.

Maciamo
25-03-17, 09:16
They state black hair and I was born blond , it became mid brown as a teenager .....................my father and grandfather and one son has black hair

Almost all Europeans (except deep south) have fair hair as children, and almost all will get darker over time. When 23andMe is making predictions about hair colour, it is only for adult colour (before greying).

Anyway, hair colour and height are probably the two most difficult things to predict based on DNA because they are not exclusively genetic, but also environmental/developmental. For example, high testosterone levels do darken hair faster.



They state blue eyes and I have mid-green eyes ............my father and grandfather had light-green eyes ............all my sons though have mid-blue eyes

So they were right. Blue here means not brown and includes green, grey or other shades.



They state blood type A- ............I was tested again recently .......I have A+ ...........all sons and their mother has A-

It's odd that they should get the Rhesus factor wrong as it's pretty straightforward - unless your genotyping was wrong. In rare cases, it happens that SNPs reported aren't correct because the genome hasn't been re-read enough times. More frequently, the i4001527 (https://www.snpedia.com/index.php/I4001527) allele linked to Rh- returns a no-call. If that is the case they would report the 'default' Rh+ instead. Could you check you data for i4001527 (https://you.23andme.com/tools/data/optin/)?

Maciamo
25-03-17, 09:42
Predicted Reality
Can Taste Bitter Compounds Probably
Prefer Savory over Sweet Snacks Correct
No Cleft Chin Correct
No Dimples Correct
No Unibrow Correct
No Widow's Peak Incorrect
Light Eyes Correct
Detached Earlobe Correct
Dark Hair Incorrect
Straight Hair Correct
Little Upper Back Hair Correct
Longer Ring than Index Finder Correct
Tan Skin Incorrect
No Freckles Correct
Lactose TolerantCorrect
Little Caffine Consumption Incorrect
Not a Deep SleeperCorrect
SprinterCorrect
Moves a lot in Sleep Incorrect


I do not have the reports for:

- cleft chin
- detached earlobes
- dimples
- unibrow
- widow's peak
- upper back hair
- skin colour
- deep sleep
- moving in sleep

Is that part of the new 23andMe experience? My account was already moved, but they won't show me my new health report, for any of the tests I ordered between 2008 and 2013. Did you guys have to order a new test to get this? Or am I not getting the updated health & trait report because I don't live in North America?

Anyway, could someone provide the SNP's for the above traits? I would be interested to check their accuracy.

Sile
25-03-17, 10:37
I do not have the reports for:

- cleft chin
- detached earlobes
- dimples
- unibrow
- widow's peak
- upper back hair
- skin colour
- deep sleep
- moving in sleep

Is that part of the new 23andMe experience? My account was already moved, but they won't show me my new health report, for any of the tests I ordered between 2008 and 2013. Did you guys have to order a new test to get this? Or am I not getting the updated health & trait report because I don't live in North America?

Anyway, could someone provide the SNP's for the above traits? I would be interested to check their accuracy.

Traits are in health reports ................if you are in one of these nations below , you will not get health reports.............so keep a record of the traits in your old 23andme

Health reports are not available in the countries listed below. If you purchase today, you will receive ancestry reports and uninterpreted raw genetic data.

As we work with regulatory bodies in each region, it is possible that additional reports or products may be available in the future; additional charges for new products or reports may apply. Regulatory bodies in some regions may have requirements that prohibit or fundamentally change specific reports or products.


Albania
Armenia
Australia
Austria
Azerbaijan
Belarus
Belgium
Bosnia and Herzegovina
Bulgaria
Croatia
Cyprus
Czech Republic
Estonia
France
Georgia
Germany
Greece
Hungary
Hong Kong
Iceland
Israel
Italy
Latvia
Liechtenstein
Lithuania
Luxembourg
Macedonia
Malta
Moldova
Monaco
New Zealand
Norway
Poland
Portugal
Romania
San Marino
Singapore
Slovakia
Slovenia
Spain
Switzerland
Vatican City

Maciamo
25-03-17, 11:00
Traits are in health reports ................if you are in one of these nations below , you will not get health reports.............so keep a record of the traits in your old 23andme

Health reports are not available in the countries listed below. If you purchase today, you will receive ancestry reports and uninterpreted raw genetic data.

As we work with regulatory bodies in each region, it is possible that additional reports or products may be available in the future; additional charges for new products or reports may apply. Regulatory bodies in some regions may have requirements that prohibit or fundamentally change specific reports or products.


Albania
Armenia
Australia
Austria
Azerbaijan
Belarus
Belgium
Bosnia and Herzegovina
Bulgaria
Croatia
Cyprus
Czech Republic
Estonia
France
Georgia
Germany
Greece
Hungary
Hong Kong
Iceland
Israel
Italy
Latvia
Liechtenstein
Lithuania
Luxembourg
Macedonia
Malta
Moldova
Monaco
New Zealand
Norway
Poland
Portugal
Romania
San Marino
Singapore
Slovakia
Slovenia
Spain
Switzerland
Vatican City




How did you get it if you live in Australia?

Regio X
25-03-17, 17:41
The report only distinguishes between blue and brown eyes. They don't make any predictions on green, hazel or mixed colours (like a yellow ring around the pupil, which is very common among blue eyed people). There is another (preliminary) report on eye colour that attempts to give odds of having green rather than blue eyes, but 23andMe doesn't make predictions on that because they probably know that there are more, yet unidentified SNPs involved. So I cannot see how you could say that they got it wrong if the eye colour in question involves green or hazel (green-yellow-brown) eyes.I'm not sure what you mean exactly. Possibly our reports are different. I'll try to explain better then. 23andMe (mine is v4) presents the genetic likelihood of eyes color this way:
LIGHTER EYES %, divided into Blue %, Greenish blue %, Green % and Light hazel %;
DARKER EYES %, divided into Dark hazel %, Light brown % and Dark brown %.
If they say you likely have dark-colored eyes and the eyes are light (green, for example), or the opposite, then the report is not correct.
At least they get right my father's eyes color, but Gedmatch missed the three. When it shows brown, it's green. When it shows green, it's brown.
That's it.

Angela
25-03-17, 18:15
I do not have the reports for:

- cleft chin
- detached earlobes
- dimples
- unibrow
- widow's peak
- upper back hair
- skin colour
- deep sleep
- moving in sleep

Is that part of the new 23andMe experience? My account was already moved, but they won't show me my new health report, for any of the tests I ordered between 2008 and 2013. Did you guys have to order a new test to get this? Or am I not getting the updated health & trait report because I don't live in North America?

Anyway, could someone provide the SNP's for the above traits? I would be interested to check their accuracy.

They just moved my account too (I've been a member since 2009). When I sign in, there's a list to the left, and one of the things on the list is "Traits". They don't list all of the snps for all of these things. I think two of the snps they use for skin pigmentation is the following, plus the blue eye gene, which has some effect.

"Variants in two genes named SLC45A2 and SLC24A5 are associated with variation in skin color in people of European and African descent. These two genes are important for proper functioning of cells that produce melanin."

Four derived versions, plus TYR etc., would lead to a prediction of "fair" skin of various shades.

I don't know why you wouldn't be getting it.

PaschalisB
25-03-17, 18:54
They just moved my account too (I've been a member since 2009). When I sign in, there's a list to the left, and one of the things on the list is "Traits". They don't list all of the snps for all of these things. I think two of the snps they use for skin pigmentation is the following, plus the blue eye gene, which has some effect.

"Variants in two genes named SLC45A2 and SLC24A5 are associated with variation in skin color in people of European and African descent. These two genes are important for proper functioning of cells that produce melanin."

Four derived versions, plus TYR etc., would lead to a prediction of "fair" skin of various shades.

I don't know why you wouldn't be getting it.

Did you order the kit from the US? Because the health reports are no longer available for European customers. After the transition to the "new experience" all we get is an reports archive of the old results.

Angela
25-03-17, 19:13
Did you order the kit from the US? Because the health reports are no longer available for European customers. After the transition to the "new experience" all we get is an reports archive of the old results.

Yes, I did, years ago. Some of those results are pretty old, though. They should be in your archive then.

Sile
25-03-17, 19:16
How did you get it if you live in Australia?

i answered post#1 with my old v3 23andme traits results .............my "transition" traits are not available

Maciamo
25-03-17, 19:50
I'm not sure what you mean exactly. Possibly our reports are different. I'll try to explain better then. 23andMe (mine is v4) presents the genetic likelihood of eyes color this way:
LIGHTER EYES %, divided into Blue %, Greenish blue %, Green % and Light hazel %;
DARKER EYES %, divided into Dark hazel %, Light brown % and Dark brown %.
If they say you likely have dark-colored eyes and the eyes are light (green, for example), or the opposite, then the report is not correct.
At least they get right my father's eyes color, but Gedmatch missed the three. When it shows brown, it's green. When it shows green, it's brown.
That's it.

Yes, it looks like the new report lists more variants of eye colours than the old one. That makes it difficult to compare the accuracy between Eupedia members. We should specific if we have the old or the new report.

PaschalisB
26-03-17, 11:04
Yes, I did, years ago. Some of those results are pretty old, though. They should be in your archive then.

The old reports are in the archive, it's the new ones that are missing.


I agree with Maciamo that it's unfair for the old customers like us who had spent so much money back then.

Regio X
27-03-17, 02:56
In rare cases, it happens that SNPs reported aren't correct because the genome hasn't been re-read enough times.Some rough statistics, just out of curiosity: As soon as my results came out, I did a program that compares 23andMe and FTDNA genotypes (I tested in both). Excluding no calls*, there are 20 differences between the SNPs (the pairs; I haven't compared the alleles in isolation) genotyped by both companies, just about 0,0154% of them. As for the no calls, it seems 23andMe guarantees a call rate of at least 98%. Between the 585560 SNPs read, 7081 of mine were uncalled, 6068 of my father and 5728 of my mother. Less than 2%.
*Considering no calls and SNP results that are in both 23andMe and FTDNA files: 943 uncalled SNPs in 23andMe were genotyped by FTDNA, and 456 uncalled in FTDNA were genotyped by 23andMe. Sometime, just for fun, I'm gonna do a program to fill part of the 23andMe uncalled SNPs with the FTDNA data, and vice-versa, but I bet it wouldn't make a relevant difference in Gedmatch calculators. :)

Regio X
27-03-17, 19:59
In rare cases, it happens that SNPs reported aren't correct because the genome hasn't been re-read enough times.Some rough statistics, just out of curiosity: As soon as my results came out, I did a program that compares 23andMe and FTDNA genotypes (I tested in both). Excluding no calls* and the X chromosome, there are just 20 differences between the SNPs (the pairs; I haven't compared the alleles in isolation) genotyped by both companies, just 0,0154% of them. As for the no calls, it seems 23andMe guarantees a call rate of at least 98%. Indeed, between the 585560 SNPs read, 7081 of mine were uncalled, 6068 of my father and 5728 of my mother. Less than 2%.
*Considering no calls and SNP results that are in both 23andMe and FTDNA files: 943 uncalled SNPs in 23andMe were genotyped by FTDNA, and 456 uncalled in FTDNA were genotyped by 23andMe. Sometime, just for fun, I'm gonna do a program to fill part of the 23andMe uncalled SNPs with the FTDNA data, and vice-versa, but I bet it wouldn't make a relevant difference in Gedmatch calculators. :)

Twilight
25-08-17, 04:08
Everything except the fact that my Index toe is longer than my big toe and not the other way around.

Jovialis
11-11-17, 22:40
https://i.imgur.com/O77doUw.png

I just upgraded to the wellness+traits feature today. I would say mine are accurate.

There were some other features they had I saw before buying it; like disease carrier status. However, they were not included, most likely due to state regulations.

Here's the wellness trait results

https://i.imgur.com/NjsqeEE.png

davef
11-11-17, 23:22
The caffeine consumption makes no sense, why are you likely to consume less when you metabolize it so quickly?

Jovialis
11-11-17, 23:32
The caffeine consumption makes no sense, why are you likely to consume less when you metabolize it so quickly?

I'm actually a slow metabolizer according to the update (https://www.eupedia.com/forum/threads/34722-Metabolism-(Hunter-Farmer-Traits)-Results-Insitome?p=522214&viewfull=1#post522214)from the insitome test. Initially it said my caffeine metabolism was faster. Nevertheless, I do drink a lot of coffee regardless.

Angela
11-11-17, 23:34
https://i.imgur.com/O77doUw.png

I just upgraded to the wellness+traits feature today. I would say mine are accurate.

There were some other features they had I saw before buying it; like disease carrier status. However, they were not included, most likely due to state regulations.

Here's the wellness trait results

https://i.imgur.com/NjsqeEE.png

Except for one or two I would say we're twins!

When you metabolize caffeine slowly it's in your bloodstream longer so you generally don't feel the need to top up, and in fact too much can make you jittery and keep you up at night. It's right for me, but it may not be right for you.

It tells me I don't get alcohol flush, like you, but I do. It's worse when I drink American wines so it may be a reaction to sulfides. Also, since I'm very pale and alcohol makes the blood circulate more, it may be more noticeable in me.

Jovialis
11-11-17, 23:45
Except for one or two I would say we're twins!

When you metabolize caffeine slowly it's in your bloodstream longer so you generally don't feel the need to top up, and in fact too much can make you jittery and keep you up at night. It's right for me, but it may not be right for you.

It tells me I don't get alcohol flush, like you, but I do. It's worse when I drink American wines so it may be a reaction to sulfides. Also, since I'm very pale and alcohol makes the blood circulate more, it may be more noticeable in me.

I do actually get flush as well. I was showing my results to my sister, and she said she noticed I do when I drink.

Jovialis
12-11-17, 19:53
Looks like I did get my carrier status and genetic heatlh risk after all. I guess it took a day to process.

Nearly a clean sweep! :smile:

https://i.imgur.com/oeWvpd7.png

https://i.imgur.com/99Pv8ma.png

https://i.imgur.com/W5J9nJb.png

https://i.imgur.com/DIpIixu.png

Angela
12-11-17, 20:42
Do they still have results for one of the breast cancer genes? You used to have to sign a special consent to get a look at it.

Jovialis
12-11-17, 20:47
Do they still have results for one of the breast cancer genes? You used to have to sign a special consent to get a look at it.

I didn't notice, these were all the tested variants I received. But I'll dig deeper when I get home.

Jovialis
13-11-17, 01:01
This article will discuss some conditions that are not included in 23andMe reports. If you are interested in learning about which conditions are included in the 23andMe Health + Ancestry Service, you can view a full list here.

23andMe does not offer diagnostic testing. For testing related to a personal or family history of a particular genetic disease, please consult a healthcare provider in order to ensure that you are pursuing the most appropriate test for your personal situation. Although we recognize there is interest in reports on the following topics, reports are not available on any of the following topics. The list below is not comprehensive, and conditions not listed here are not necessarily included in our current 23andMe reports.


Hereditary risks for some adult onset diseases like cancer, diabetes and heart disease
Hereditary cancer syndromes such as Hereditary Breast and Ovarian Cancer syndrome (HBOC) (BRCA genes) or the hereditary colon cancer syndromes - Lynch syndrome (HNPCC) or familial adenomatous polyposis (FAP)
Drug response (for example: CYP2D6 and certain HLA alleles)
Copy number variations (CNVs), balanced rearrangements and mosaicism
MTHFR analysis, such as a targeted mutation analysis, methylation analysis or detox profile


https://customercare.23andme.com/hc/en-us/articles/236409067-Conditions-NOT-included-in-23andMe

Looks like they've omitted it, unfortunately.

Here's a list of the current reports:

https://www.23andme.com/dna-health-ancestry/#all-reports-list

Angela
13-11-17, 01:31
Looks like they've omitted it, unfortunately.

Here's a list of the current reports:

https://www.23andme.com/dna-health-ancestry/#all-reports-list

I guess that was part of the agreement with the government. It's too bad, because I think it's a good one for women to know as soon as possible.

davef
13-11-17, 05:14
Why would the government want that omitted???

Angela
13-11-17, 21:35
23andme was prohibited from continuing to sell what was considered diagnostic health information to the general public. The concern seems to have been that people could freak out learning that they have the so called "breast cancer" gene, for example.

The company had to do some tricky negotiations to be allowed to provide some "health related" information.

It's stupid, in my opinion. Once you have your raw data you can check for the snps yourself if you choose, for one thing. For another, I think I have the right to know if I carry it. Why make me go through the hassle of combing through the data myself?

It could also save someone's life. The government's position was that if there's breast cancer in your family you should go to your doctor and ask to have the test done.

My best friend carried this gene. During her second pregnancy they found a large mass. It killed her after an agonizing seven years. All of her close family had died in the Holocaust except for her parents, so she had no idea it ran in her family. Had she known, perhaps she would have gotten mammograms from a very young age. Perhaps she could have had a preventive double mastectomy, like Angelina Jolie. It's just not right to not let you have at least some of that information.

davef
13-11-17, 21:55
Thanks, and wouldn't a more obvious solution be to include this sort of information as an option with a disclaimer?

Angela
14-11-17, 02:44
It was offered as an option with a disclaimer, along with results for some other terrible diseases. It wasn't enough for the government agencies.

davef
14-11-17, 05:00
You mean the nannies?

Seriously, Im sure the number of freak outs would be far less than the number of deaths that it would've prevented.

Fatherland
08-06-19, 21:38
Extremely accurate in my case. Perhaps the old 23andme v3 chip(that I was part of) is higher quality and the newer chips are Made in China, thus making it less accurate for some?

I had platinum blond hair as kid, now it's just blond:

https://i.imgur.com/VYF2CEf.png





Eyecolor blue:

https://i.imgur.com/NybYkhZ.png

+ all the SNPs for light, non-freckled skin.