Johane Derite
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- U1a1a
LINK: http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2017121a.html?foxtrotcallback=true
"Individuals with extremely high intelligence were recruited from the Duke University Talent Identification Program (TIP), a non-profit organization established in 1980and dedicated to identifying and fostering the development of academically gifted children. For the present study, TIP cases were selected and DNA solicited from the top 1% of these TIP individuals,
representing approximately the top 0.03% of the intelligence distribution (~170 mean IQ)
After performing the GWA single SNP analysis using an additive model for 6 773 587 SNPs, three intronic SNPs: rs4962322, rs4962520 and rs10794073 located in ADAM12 on chromosome 10 reached genome-wide significant P-values of 8.0 × 10−9, 1.2 × 10−8 and 2.0 × 10−8, respectively. The three SNPs are in high LD with r2 ranging between 0.9 and 1.0, with rs4962322 representing the sentinel SNP after clumping. ADAM12 encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development and neurogenesis.
"In summary, we have shown that extremely high intelligence is a polygenic trait and its high heritability indicates that GWA analysis captures a large portion of the genetic variance.
The novel aspect of the present study is that it represents a complementary strategy to the ‘brute force’ approach of increasing sample sizes of GWA studies of IQ variation in the
normal range (and is an example for quantitative trait genetics in general). It demonstrates the utility of a ‘positive genetics’ strategy of focusing on the extremely high end of the
distribution of IQ. Larger scale studies focusing on either high IQ or IQ in the normal range are likely to be successful in the identification of many significant loci and biological pathways."
"Individuals with extremely high intelligence were recruited from the Duke University Talent Identification Program (TIP), a non-profit organization established in 1980and dedicated to identifying and fostering the development of academically gifted children. For the present study, TIP cases were selected and DNA solicited from the top 1% of these TIP individuals,
representing approximately the top 0.03% of the intelligence distribution (~170 mean IQ)
After performing the GWA single SNP analysis using an additive model for 6 773 587 SNPs, three intronic SNPs: rs4962322, rs4962520 and rs10794073 located in ADAM12 on chromosome 10 reached genome-wide significant P-values of 8.0 × 10−9, 1.2 × 10−8 and 2.0 × 10−8, respectively. The three SNPs are in high LD with r2 ranging between 0.9 and 1.0, with rs4962322 representing the sentinel SNP after clumping. ADAM12 encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development and neurogenesis.
"In summary, we have shown that extremely high intelligence is a polygenic trait and its high heritability indicates that GWA analysis captures a large portion of the genetic variance.
The novel aspect of the present study is that it represents a complementary strategy to the ‘brute force’ approach of increasing sample sizes of GWA studies of IQ variation in the
normal range (and is an example for quantitative trait genetics in general). It demonstrates the utility of a ‘positive genetics’ strategy of focusing on the extremely high end of the
distribution of IQ. Larger scale studies focusing on either high IQ or IQ in the normal range are likely to be successful in the identification of many significant loci and biological pathways."