View Full Version : Heritability of Schizophrenia

02-09-17, 18:23
I'd say there's virtually no doubt anymore that this is a highly heritable disease. It's so terrible when this runs in families.


"AbstractTwin studies have provided evidence that both genetic and environmental factors contribute to schizophrenia risk. Heritability estimates of schizophrenia in twin samples have varied methodologically. This study provides updated heritability estimates based on nationwide twin data and an improved statistical methodology."

"The probandwise concordance rate of schizophrenia is 33% in monozygotic (MZ) twins and 7% in dizygotic (DZ) twins. We estimated the heritability of schizophrenia to be 79%. When expanding illness outcome to include schizophrenia spectrum disorders, the heritability estimate was almost similar, 73%."