PDA

View Full Version : The Ancient Origins of Neural Substrates for Land Walking



Jovialis
10-02-18, 18:03
Researchers have determined that the neural circuitry, and genes for walking found in animals, were developed 420 million years before the first little skates (Leucoraja erinacea) and tetrapods. Which is way before the evolution of limbs used for the means of walking movements.

https://phys.org/news/2018-02-fish-scientists-left-ocean.html



The Ancient Origins of Neural Substrates for Land Walking
Walking is the predominant locomotor behavior expressed by land-dwelling vertebrates, but it is unknown when the neural circuits that are essential for limb control first appeared. Certain fish species display walking-like behaviors, raising the possibility that the underlying circuitry originated in primitive marine vertebrates. We show that the neural substrates of bipedalism are present in the little skate Leucoraja erinacea, whose common ancestor with tetrapods existed ∼420 million years ago. Leucoraja exhibits core features of tetrapod locomotor gaits, including left-right alternation and reciprocal extension-flexion of the pelvic fins. Leucoraja also deploys a remarkably conserved Hox transcription factor-dependent program that is essential for selective innervation of fin/limb muscle. This network encodes peripheral connectivity modules that are distinct from those used in axial muscle-based swimming and has apparently been diminished in most modern fish. These findings indicate that the circuits that are essential for walking evolved through adaptation of a genetic regulatory network shared by all vertebrates with paired appendages.

http://www.cell.com/cell/fulltext/S0092-8674(18)30050-3

Jovialis
10-02-18, 18:29
video.nationalgeographic.com/video/news/180209-little-skate-walking-gene-vin-spd

Here's a video by national geographic on this study, to illustrate the topic.