Ancient hepatitis B viruses from the Bronze Age to the Medieval period

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Here's another study in relation to the others that came out today:

Ancient hepatitis B viruses from the Bronze Age to the Medieval period

Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the genome properties follow those of modern HBV. The root of the HBV tree is projected to between 8.6 and 20.9 thousand years ago, and we estimate a substitution rate of 8.04 × 10−6–1.51 × 10−5 nucleotide substitutions per site per year. In several cases, the geographical locations of the ancient genotypes do not match present-day distributions. Genotypes that today are typical of Africa and Asia, and a subgenotype from India, are shown to have an early Eurasian presence. The geographical and temporal patterns that we observe in ancient and modern HBV genotypes are compatible with well-documented human migrations during the Bronze and Iron Ages1,2. We provide evidence for the creation of HBV genotype A via recombination, and for a long-term association of modern HBV genotypes with humans, including the discovery of a human genotype that is now extinct. These data expose a complexity of HBV evolution that is not evident when considering modern sequences alone.


https://www.nature.com/articles/s41586-018-0097-z

Horse domestication changed the face of Eurasia, helping ancient Huns and Mongols supplant western "Indo-European" farmers in an incremental westward drive that also brought Hepatitis B and plague, scientists said Wednesday.

In three studies published in the journals Science and Nature, experts reported sequencing the genomes of dozens of humans who lived between 2,500 BC and 1,500 AD—a 4,000-year period from the Iron Age to medieval times.

Their analysis showed a slow and steady west-to-east shift in the genetic makeup of the people who populated the Eurasian steppe—a massive expanse stretching from Hungary and Romania in the west to Mongolia and northeast China in the east.

According to the data, the steppe population changed "from being of mainly western Eurasian genetic ancestry to... east Asian genetic ancestry," said Eske Willerslev of the University of Copenhagen, who co-authored two of the studies.

"It's also changing the steppe in terms of being Indo-European speakers to becoming Turkish-speaking people."

The Indo-European language group gave rise to modern-day tongues such as English, French, German, Russian, Hindi, and Persian, while Turkish is part of the Turkic language group thought to have originated in east Asia, including Mongolia.

From about 800 to 200 BC, the Eurasian steppe was dominated by the Scythians, a group of Iranian-speaking mounted warriors, the researchers said.

These were thought to have originated from Bronze Age farmers of western "European" ancestry.

Yet today, "the people living in central Asia and western Asia are really of Asian descent," said Willerslev. "We wanted to understand how this happened."

The Scythians, they found, were "absorbed and replaced" by Huns spreading westward out of Mongolia, "killing all the people they met but also mixing with them".

Hold your horses!

When the Hun empire collapsed about 1,500 years ago, other groups started moving westward—most famously the Mongols.

"You can say that the vast majority of the genetic makeup of contemporary people in this 8,000 kilometre-long (4,971 mile) stretch across Europe and Asia has really mainly been formed within the last approximately 1,000 years," Willerslev told journalists.

For his colleague and co-author Peter de Barros Damgaard, a highlight of the research is to show how horse herding and riding changed the face of Eurasia.

"Starting with the domestication of course, which enabled these groups to grow in number and this expansion of pastoralist societies and then later, as we move into the late Bronze Age, we have the invention of the spoke wheel chariot which connects south Asia with Europe and establishes these huge trade routes," he explained.

"The next big change in the use of horses is to actually start riding them and shooting with bow and arrow as mounted warriors, and this infuses a military dynamic into the steppe"—leading to a constant changes in empire and the genetic makeup of conquered populations.

The researchers also found that the Justinian plague pandemic, which killed millions of people on the European continent in the years 541 and 542, had come with the east Asian conquerers.

"Some people have argued it came from Greece," said Willerslev, but bacterial DNA found in the remains of two ancient humans shows "it was probably brought to Europe by the Mongol expansion".

Finally, the research showed that Hepatitis B, which kills almost a million every year due to complications such as liver cancer, was already present in Eurasia some 4,500 years ago.

Scientists are keen to learn more about when the virus arose, and the rate by which it mutates.

Read more at: https://phys.org/news/2018-05-horse-riding-eurasia-ethnic-profile.html#jCp

 
Here's another study in relation to the others that came out today:

Unbelievable. Every freaking time there's migration from the steppe it brings plague with it. Now hepatitis B as well?
 
Justinian Plague absolutely came from China via the Huns. No wonder everyone thought they were the biblical horsemen of the apocalypse.
 
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blaim the chickens in China

Flu and influenza come from chickens in China. Plague comes from rodents on the steppe. I posted the science on it upthread.
 
Plague comes from rodents on the steppe.

The virulent plague strains that can transmit through fleas definitely come from the steppe, but those strains can be traced further back to China.

So I'm allowed to blame China for this as well as influenza.
 
The virulent plague strains that can transmit through fleas definitely come from the steppe, but those strains can be traced further back to China.
So I'm allowed to blame China for this as well as influenza.
I was joking about the chickens, but my guess is China too.
5 ka there were certainly contacts between the steppe and China, through NW China and the Hexi corridor.
It is there and then that the first Chinese copper, bronze and horses were found. The Chinese didn't invent all this themselves suddenly as the Afanasievo arrived in the Altaï.
Maybe it went both ways, maybe the Chinese got TBC which developped in the middle east (Atlit Yam) as a consequence of domesticating animals.
 
I was joking about the chickens, but my guess is China too.
5 ka there was certainly contacts between the steppe and China, through NW China and the Hexi corridor.
It is there that the first Chinese copper, bronze and horses were found. The Chinese didn't invent all this themselves.

Yeah the paper does a pretty good job at tracing the plague back to the steppe where it became most virulent, then further into China where it wasn't as virulent.

And the Chinese definitely got Horses from Iranians, and Bronze from Iranians or Tocharians. The horse part was proven in the latest paper on genetics of domestic horses.
 

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