hla

  1. Maciamo

    HLA-DR14 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR14. The maximum frequencies are observed in Kosovo (8.5%), Albania (7.5%), South Italy (7.5%), Georgia (7.5%), Romania (7%), Macedonia (6.7%), Greece (6.5% but 4% in Crete), Armenia (6.5%). DR14 is virtually absent from the Sardinian, Basque...
  2. Maciamo

    HLA-DR10 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR10. The maximum frequencies are observed in the Lebanon (5.2%), Saudi Arabia (4.8%), Palestine (4.7%), Jordan (3.8%), Morocco (3.3%), Algeria (3%), Tunisia (3%), and oddly enough also among the Saami people (2.9%). It is absent from the Basque...
  3. Maciamo

    HLA-DR13 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR13. Unlikely most other HLA types, DR13 does not show any specific geographic pattern or associated with ethnic groups or Y-DNA haplogroup. This is because DR13 is in fact divided in three major subclades and patterns are only meaningful within...
  4. Maciamo

    HLA-DR9 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR9. It is overall an North Asian HLA type, although it is also found in Lebanon and the Maghreb (but Lebanese do have 1-2% of North Asian DNA associated with Y-DNA haplogroup Q1b). The maximum frequencies are observed among the Saami (7 to 16%...
  5. Maciamo

    SNPs linked to HLA-DR types in Europeans/Caucasians

    The HLA gene regulates our acquired immune system. It is what helps our body identify foreign antigens (bacteria, fungi, viruses) and determine what type of white blood cells and antibodies should be produced. Depending on our HLA type we are more or less resistant to certain diseases and...
  6. Maciamo

    HLA-DR7 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR7. The maximum frequencies are observed in the Basque country (26 to 31%), northern Catalonia (23%), the Balearic Islands (22%), Cantabria (20%), Tunisia (19%), Saudi Arabia (18%), Andalusia (17.5%), Libya (17%), and in Ireland (16%). You...
  7. Maciamo

    HLA-DR15: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR15. The maximum frequencies are observed in the Pasiegos of Cantabria in northern Spain (32%), the Chuvash of the Volga region (19.5%), Ireland (18.5%), Denmark (18.5%), Brittany (18%), Orkney (18%), Norway (15.5%) and Sweden (15.5%). DR15...
  8. Maciamo

    HLA-DR3 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR3. The maximum frequencies are observed in Sardinia (56%), the Basque country (19.5%), Ireland (18%), Morocco (16.5%), Tunisia (16.5%), Libya (15.5%), Saudi Arabia (15.5%), Belgium (15.5%), Wales (15%), Algeria (15%), England/Scotland (14.5%)...
  9. Maciamo

    HLA-DR16: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR16. The maximum frequencies are observed in the United Emirates (18%), Bulgaria (17.5%), Macedonia (15.5%), Greece (13.5%), Albania (12.5%), Serbia (11%), Croatia (10.5%) and Sardinia (10.5%). It is completely absent from the Saami, Breton...
  10. Maciamo

    HLA-DR1: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR1. The maximum frequencies are observed in the Volga-Ural region, among the Mari (24%), Chuvash (18.5%), Kostroma Russians (17.5%) and South Ural Russians (16%). Subtypes There are three main subclades of DR1: - DRB1*01:01 : the vast...
  11. Maciamo

    HLA-A3: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-A3, which is divided in two subtypes : A3:01 and A3:02. The former is mostly found in Europe, with lower frequencies across the Middle East, Central Asia (Uygurs), India and even isolated parts of Africa (Cameroon). The latter peaks in Georgia...
  12. Maciamo

    HLA-DQ8 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DQ8. The world's highest frequencies are observed in Central and South America (up to 80%), then in Siberia (11-22%). It has been suggested that a migration from people east of the Urals is responsible for DQ8. The strongest association with...
  13. Maciamo

    HLA-DQ2 : distribution map, subtypes, SNPs, and associated medical conditions

    Here is a map showing the allele frequency of HLA-DQ2. The world's highest frequencies are observed among the Sardinians (59%), the Basques (48%), the Brahui and Balochi of Pakistan (40%), the Moroccans (35%) and the Saudis (35%). Subtypes HLA-DQ2 comprises two subtypes DQB1*0201 and...
  14. Maciamo

    HLA-B27 : distribution map and associated medical conditions

    Here is a map showing the allele frequency of HLA-B27. The maximum frequencies are observed among the Saami (20% in northern Sweden, 15% in Norway), then in the rest of Fennoscandia, in Belgium, England and Scotland. HLA-B27 is the most routinely tested HLA types by doctors because carrying...
  15. Maciamo

    HLA-DR4 : distribution map, subtypes frequencies and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR4. The maximum frequencies are observed among Murmansk Saami, Norwegians, Welsh, Southwest English, Belgians and Armenians. Subtypes DR4 has over 100 subtypes (subclades). Here is the distribution of the 10 most common. DRB1*04:01: peaks...
  16. Maciamo

    HLA-DR11 : distribution map, subtypes frequencies and associated medical conditions

    I have made a map showing the allele frequency of HLA-DRB1*11, aka HLA-DR11. It clearly seems to have a West Asian origin, and probably spread alongside Y-DNA haplogroup J2 considering the high frequencies of both in Iran, Armenia, Turkey, Greece, Albania and Italy. The Saudis and North Africans...
  17. Maciamo

    Distribution of HLA-A types by country

    I have started a new page listing HLA allele frequencies by country. I have only had time to add HLA-A types so far, but I am planning to add other types too. There are 14 common HLA-A types in Europe. Some geographic patterns are quite obvious for some types. HLA-A1 is found at highest...
  18. Maciamo

    New map of HLA-A1 allele frequency

    Here is my first HLA map. I chose to start with HLA-A1 because it is the first chronologically, but also because it is one of the most common HLA types in Europe. The HLA (Human Leucocyte Antigen) genes are on important component of the immune system regulation. They are cell-surface...
Back
Top