Yeah, generally there is the question if Ötzi has any living descendants, just like the people from the Lichtenstein Cave have. It is already established that Ötzi's mitochondrial Haplogroup doesn't exist anymore, but obviously, he himself could never passed it on, anyways. Now, what I am especially curious about is Ötzi's Y-Haplogroup. I personally expect some variety of Haplogroup I2, but he might have had something else.