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    Post HLA-B27 : distribution map and associated medical conditions

    Here is a map showing the allele frequency of HLA-B27. The maximum frequencies are observed among the Saami (20% in northern Sweden, 15% in Norway), then in the rest of Fennoscandia, in Belgium, England and Scotland.

    HLA-B27 is the most routinely tested HLA types by doctors because carrying this allele greatly increases the risk of developing ankylosing spondylitis (AS), and other associated inflammatory diseases referred to as "spondyloarthropathies". About 12% of B27 carriers will develop this debilitating autoimmune disease of the lower axial spine and nearby joints. The onset of the disease is typically between 15 and 25 years old and there is no cure at present.

    You can check if you carry the allele for HLA-B27 if you tested your genome with 23andMe, Geno 2.0 or FamilyFinder. The SNP for HLA-B*27:05, the most common variant in Europe, is rs6919835 (the A allele means carrier). I have checked ancient genomes from Haak et al 2015, and only one sample (Neolithic Spain) was positive for B27.

    Last edited by Maciamo; 21-04-15 at 19:41.
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