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Thread: Gene Regulation Question

  1. #1
    Junior Member
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    Gene Regulation Question

    Hi all, I'm wondering why there are more scientific papers published on methylation over acetylation. On PubMed, there are 50k results when I type in "DNA methylation", but only 12k results when I type in "histone acetylation". Is there any clear reason why? Methylation being easier to assay, having more clinical importance, or being discovered earlier? Please let me know.

  2. #2
    Advisor LeBrok's Avatar
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    Y-DNA haplogroup
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    Very good questions. I noticed that too and we need answers.
    Does sequencing of Dna strips genes of these groups therefore can't tell us which gene is active or not?
    Be wary of people who tend to glorify the past, underestimate the present, and demonize the future.

  3. #3
    Junior Member
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    I believe bisulfite sequencing helps for methylation, but more advanced protocols are needed for acetylation, using enzymes, RNA, or antibodies.

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