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Thread: HLA-DR9 : distribution map, subtypes, SNPs and associated medical conditions

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    Post HLA-DR9 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR9. It is overall an North Asian HLA type, although it is also found in Lebanon and the Maghreb (but Lebanese do have 1-2% of North Asian DNA associated with Y-DNA haplogroup Q1b). The maximum frequencies are observed among the Saami (7 to 16% depending on the sampling region), then in Volga-Ural ethnic groups such as the Mari (11.5%), Bashkirs (5%), Chuvash (5%) and Tatars (3.5%). In Asia, DR9 peaks in East Siberia (28%) but is also very common in China and Taiwan (10-15% depending on the region).

    In eastern and northern Europe HLA-DR9 is strongly correlated with Y-haplogroups N1c and Q1a, and to a lower extent also with with East Asian admixture. This correlation diminishes as we move west and south, but is found at higher frequencies in region with more Nordic/Viking ancestry, including Northwest Iberia (Suebi). The Basques also have a bit more DR9 than the Spanish average and also happen to have 1% of Y-haplogroup Q, although it is unknown where this comes from.




    Medical associations

    HLA-DR9 is associated with early childhood myastenia gravis.


    SNP's

    You can verify if you carry HLA-DR9 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. Almost all Europeans belong to the DRB1*09:01 subclade.

    - DRB1*09:01 : rs2395185 (T), rs2516049 (C)

    You normally need to be positive for both alleles.
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    Quote Originally Posted by Maciamo View Post
    Here is a map showing the allele frequency of HLA-DR9. It is overall an North Asian HLA type, although it is also found in Lebanon and the Maghreb (but Lebanese do have 1-2% of North Asian DNA associated with Y-DNA haplogroup Q1b). The maximum frequencies are observed among the Saami (7 to 16% depending on the sampling region), then in Volga-Ural ethnic groups such as the Mari (11.5%), Bashkirs (5%), Chuvash (5%) and Tatars (3.5%). In Asia, DR9 peaks in East Siberia (28%) but is also very common in China and Taiwan (10-15% depending on the region).

    In eastern and northern Europe HLA-DR9 is strongly correlated with Y-haplogroups N1c and Q1a, and to a lower extent also with with East Asian admixture. This correlation diminishes as we move west and south, but is found at higher frequencies in region with more Nordic/Viking ancestry, including Northwest Iberia (Suebi). The Basques also have a bit more DR9 than the Spanish average and also happen to have 1% of Y-haplogroup Q, although it is unknown where this comes from.




    Medical associations

    HLA-DR9 is associated with early childhood myastenia gravis.


    SNP's

    You can verify if you carry HLA-DR9 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. Almost all Europeans belong to the DRB1*09:01 subclade.

    - DRB1*09:01 : rs2395185 (T), rs2516049 (C)

    You normally need to be positive for both alleles.

    rs2395185 G or T GG
    Andrew


    GT
    Lucien


    GT
    victor


    rs2516049 C or T TT
    Andrew


    CT
    Lucien


    CT
    victor
    có che un pòpoło no 'l defende pi ła só łéngua el xe prónto par èser s'ciavo

    when a people no longer dares to defend its language it is ripe for slavery.

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