Hi,
I am not an expert in the field of population genetics and I have a question about some recent data we have.
We see one allele variant in HW-deviation in 2 unrelated populations (chi sq. 12 and 9, respectively), but only in disease cases (we're studying ALS, we tested 200 controls and 200 disease cases for each population).
What could be in your opinion the possible interpretation of this observation? Is the allele under selection in the disease, or maybe a bottleneck effect due to small sample size?
Thank you in advance.
I am not an expert in the field of population genetics and I have a question about some recent data we have.
We see one allele variant in HW-deviation in 2 unrelated populations (chi sq. 12 and 9, respectively), but only in disease cases (we're studying ALS, we tested 200 controls and 200 disease cases for each population).
What could be in your opinion the possible interpretation of this observation? Is the allele under selection in the disease, or maybe a bottleneck effect due to small sample size?
Thank you in advance.