Eupedia Forums
Site NavigationEupedia Top > Eupedia Forum & Japan Forum
Results 1 to 3 of 3

Thread: Allele in Hardy-Weinberg deviation

  1. #1
    Junior Member
    Join Date

    Country: Italy

    Allele in Hardy-Weinberg deviation

    I am not an expert in the field of population genetics and I have a question about some recent data we have.

    We see one allele variant in HW-deviation in 2 unrelated populations (chi sq. 12 and 9, respectively), but only in disease cases (we're studying ALS, we tested 200 controls and 200 disease cases for each population).

    What could be in your opinion the possible interpretation of this observation? Is the allele under selection in the disease, or maybe a bottleneck effect due to small sample size?

    Thank you in advance.

  2. #2
    Advisor LeBrok's Avatar
    Join Date

    Y-DNA haplogroup
    R1b Z2109
    MtDNA haplogroup

    Ethnic group
    Citizen of the world
    Country: Canada-Alberta

    1 members found this post helpful.
    I'm not population geneticist either, but I would guess that our genetic knowledge is still too limited to give definitive answer to your question. Especially when control sample is so small and we don't have a clue how it evolved through past generations.
    Neutral or mildly deleterious alleles could linger through millennia in populations, till replaced with a very fit one, or by other neutral due to population bottlenecking.
    Sometimes genes have double functions. In this case it might have a second function which is very beneficial. Sometimes alleles are very beneficial only in connections with other genes' alleles, but alone are neutral.

    All I got. ;)
    Be wary of people who tend to glorify the past, underestimate the present, and demonize the future.

  3. #3
    Junior Member
    Join Date

    Country: Italy

    Thank you for your kind explanation, I understand and agree!

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts