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I would hesitate to make any predictions about the population genetics of Sicily using samples from Palermo. As the capital, it has absorbed people from all over the island, the mainland, and even abroad.
Messina is even worse. It was hit by three massive earthquakes from the late 19th to early 20th century. The last one so devastated the town itself and killed so many people that the town had to be rebuilt from scratch and was repopulated with people from other parts of Sicily and the mainland. I don't know what we could tell from those results.
Also, unlike areas in the north where there was for centuries a patchwork of states, some ruled by foreign countries, and so it was difficult to move to other "jurisdictions", helping to maintain even sub-regional genetic structures, Sicily has always been one unit. People have been moving around for thousands of years. Even if you can find older people who have all four grandparents from one town, that doesn't mean there wasn't a lot of movement in the past. It's not like testing one mountain valley, as was the case with the Calabrian Greek speakers, who are a very drifted population where everyone is basically everyone else's cousin, and probably a certain admixture signature would be common to all of them.
Anyway, the academic papers so far haven't found a lot of sub-structure in Sicily, although if testing ever becomes popular or the academics have the interest in collecting lots of samples from different regions, some might show up.
Non si fa il proprio dovere perchè qualcuno ci dica grazie, lo si fa per principio, per se stessi, per la propria dignità . Oriana Fallaci