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Thread: Insitome Results! (Neanderthal)

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    Advisor Jovialis's Avatar
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    2 members found this post helpful.

    Post Insitome Results! (Neanderthal)

    https://www.eupedia.com/forum/thread...l=1#post565280

    Since I'm already a Helix customer, I procured Insitome (Neanderthal chapter) for $29.99. Moreover, my results were ready in 5 minutes, since my DNA is already sequenced. They will be rolling out with other chapters that will be avaliable for purchase in the future.

    Below are screen caps from my results. According to Insitome, I am 1.2% Neanderthal (National Geographic-Helix had me at 1.4% )

    Moreover, they tell you what Neanderthal traits you have inherited, and which are human. They also tell you what specific gene you have acquired from admixture.

    I literally have the mind of a Neanderthal!












    Last edited by Jovialis; 04-02-19 at 11:22.

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    Here's a list of the genes the test has revealed to me. I have also provided links on information for each.

    There were two Neanderthal genes in the test that I couldn't find information on (Haplotype III, and Haplotype IV). If anyone could provide it to me, it would be much appreciated. I'd like to spend time reading up on all of these genes, and figure out what they really mean.

    MC1R
    https://ghr.nlm.nih.gov/gene/MC1R


    //


    C4orf45
    https://www.ncbi.nlm.nih.gov/gene/152940


    IFRD2
    https://www.ncbi.nlm.nih.gov/gene/7866


    NAT6
    https://www.ncbi.nlm.nih.gov/gene/24142


    ZYMND10
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738835/


    SEMA3B
    https://www.ncbi.nlm.nih.gov/gene/7869


    HYAL2
    https://www.ncbi.nlm.nih.gov/gene/8692


    HYAL1
    https://www.ncbi.nlm.nih.gov/gene/3373


    RASSF1
    https://www.ncbi.nlm.nih.gov/gene/11186


    CYB561D2
    https://www.ncbi.nlm.nih.gov/gene/11068


    NPRL2
    https://www.ncbi.nlm.nih.gov/gene/10641


    TUSC2
    https://www.ncbi.nlm.nih.gov/gene/11334


    //


    NEB
    https://www.ncbi.nlm.nih.gov/gene/4703


    CUL7
    https://www.ncbi.nlm.nih.gov/gene/9820


    HSPG2
    https://www.ncbi.nlm.nih.gov/gene/3339


    //


    CHST10
    https://www.ncbi.nlm.nih.gov/gene/9486


    CYP7B1
    https://www.ncbi.nlm.nih.gov/gene/9420


    GRIN2A
    https://ghr.nlm.nih.gov/gene/GRIN2A


    GLP1R
    https://www.ncbi.nlm.nih.gov/gene/2740


    NGF
    https://www.ncbi.nlm.nih.gov/gene/4803


    OXT
    https://www.ncbi.nlm.nih.gov/gene/5020


    GALR2
    https://www.ncbi.nlm.nih.gov/gene/8811


    MUSK
    https://www.ncbi.nlm.nih.gov/gene/4593


    TANC1
    https://www.ncbi.nlm.nih.gov/gene/85461


    SLC6A4
    https://www.ncbi.nlm.nih.gov/gene/6532


    OXTR
    https://www.ncbi.nlm.nih.gov/gene/5021


    RELN
    https://www.ncbi.nlm.nih.gov/gene/5649


    IL1RN
    https://www.ncbi.nlm.nih.gov/gene/3557


    APBB1IP
    https://www.ncbi.nlm.nih.gov/gene/54518


    //


    WARS2
    https://www.ncbi.nlm.nih.gov/gene/10352


    TBX15
    https://www.ncbi.nlm.nih.gov/gene/6913


    //


    EPAS1
    https://www.ncbi.nlm.nih.gov/gene/2034


    //


    STAT2
    https://www.ncbi.nlm.nih.gov/gene/6773


    //


    Haplotype III


    TLR1
    https://www.ncbi.nlm.nih.gov/gene/7096


    Haplotype IV


    TLR6
    https://www.ncbi.nlm.nih.gov/gene/10333


    TLR10
    https://www.ncbi.nlm.nih.gov/gene/81793


    //


    OAS3
    https://www.ncbi.nlm.nih.gov/gene/4940


    OAS1
    https://ghr.nlm.nih.gov/gene/OAS1


    OAS2
    https://www.ncbi.nlm.nih.gov/gene/4939


    DTX1
    https://www.ncbi.nlm.nih.gov/gene/1840


    //


    DMD
    https://ghr.nlm.nih.gov/gene/DMD

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    1 members found this post helpful.
    What's fascinating is that you have a high IQ, yet some of your Neanderthal genes are genes that determine intellectual ability! Something tells me that there may have been gifted Neanderthals (gifted on a human scale) and that they may have been more sophisticated than expected.

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    WARS2
    https://www.ncbi.nlm.nih.gov/gene/10352


    TBX15
    https://www.ncbi.nlm.nih.gov/gene/6913

    Found something interesting regarding these two genes. They were inherited by admixture with Denosivian. Apparently, this gene was developed to withstand cold areas in the Arctic. Today, nearly 100% of Greenland Inuit have WARS2, and it is found in lower frequency with Modern Europeans, and Asians.

    Perhaps it comes from western Neanderthals intermixing with eastern Neanderthals (Denosivian), prior to intermixing with Modern Homo sapiens.

    Or perhaps it has something to do with my eastern and/or northeastern European autosomal admixture.



    Furthermore, I learned this from the "Genius match" from NG. The paternal-lineage that went on to become haplogroup R1a/R1b took a turn into Asia, prior to Europe, back when it was M207. They probably picked up some admixture with the Eastern Neanderthal (Denosvian). I would like to hear from someone with more knowledge about this lineage, in regards to my hypothesis.



    65,000-45,000 years ago

    Humans have just ventured out of Africa on their way to conquer the world. Yet these pioneers are still limited to South and Southwest Asia, where they are encountering new animals and plants, like nothing they had known from ancestral Africa.

    During this time, I shared a common ancestor with:



    • Thomas Jefferson (Paternal Match)
    • Nikola Tesla (Paternal Match)
    • Petrarch (Maternal Match)
    • Abraham Lincoln (Maternal Match)
    • Genghis Khan (Paternal Match)
    • Leo Tolstoy (Paternal Match



    Above is a screencap from the insitome description of my fat storage.

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    Quote Originally Posted by davef View Post
    What's fascinating is that you have a high IQ, yet some of your Neanderthal genes are genes that determine intellectual ability! Something tells me that there may have been gifted Neanderthals (gifted on a human scale) and that they may have been more sophisticated than expected.
    I haven't delved into the 14 Neanderthal genes associated with intelligence yet. But apparently, TANC1 has a lot to do with visual learning.

    I usually found myself to be very bored in school as a child. My teachers often complained that I wouldn't "sit still", in class. Nevertheless, I always liked learning, on my own terms. I guess I found grammar school to be very under-stimulating. I had very old teachers, and this was back in the early 90s too. I'm sure a lot has changed.

    EDIT:

    Just saw this article regarding Neanderthal genes and their effect on the brain and cranium.

    https://www.nature.com/articles/s41598-017-06587-0

    EDIT2:

    I made a thread about it.

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    Quote Originally Posted by davef View Post
    What's fascinating is that you have a high IQ, yet some of your Neanderthal genes are genes that determine intellectual ability! Something tells me that there may have been gifted Neanderthals (gifted on a human scale) and that they may have been more sophisticated than expected.
    I would guess that there are thousands genes regulating brain functions, architecture, neuronal connection and speed, etc. One allele, Neanderthal or not, won't change much in most cases.
    Be wary of people who tend to glorify the past, underestimate the present, and demonize the future.

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    Quote Originally Posted by LeBrok View Post
    One allele, Neanderthal or not, won't change much in most cases.
    I don't know how well this works as a general rule. You only need to inherit one copy of the faulty allele to have Huntington's disorder

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    Quote Originally Posted by Johane Derite View Post
    I don't know how well this works as a general rule. You only need to inherit one copy of the faulty allele to have Huntington's disorder
    In this case we are talking about working allele from a very close cousin, and it worked fine in humans for thousands of years. The point was not to expect a dramatic improvement in brain function. Possible but unlikely.

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    1 members found this post helpful.
    For a critical view on this study about Neanderthal brain structure:

    "Small sample size, w. seemingly relatively little discussion of pop structure. Not sure I'd bet on it."
    https://twitter.com/Graham_Coop


    Non si fa il proprio dovere perchè qualcuno ci dica grazie, lo si fa per principio, per se stessi, per la propria dignità. Oriana Fallaci

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    Quote Originally Posted by Angela View Post
    For a critical view on this study about Neanderthal brain structure:

    "Small sample size, w. seemingly relatively little discussion of pop structure. Not sure I'd bet on it."
    https://twitter.com/Graham_Coop
    Ah, that's unfortunate.

    I hope scientists produce a more rigorous study on this subject in the future.

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    After reading further in-dept into the test results, I find the descriptions for the genes to be dubious.

    For example, it says I have Human muscle growth and development. Yet the description says the gene DMD is a result of Neanderthal admixture. Does this mean, I don't have the DMD gene? Or even though it's a Human version, it was spawned out of admixture between Neanderthals and Humans?

    The same goes for all of the descriptions that say "Human version". They say they're a result of admixture with Homo Sapiens and Neanderthals or Denosivans.





    EDIT: I just messaged Insitome about this question.

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    Yeah, i guess what makes it a human version is the fact that it's at least partially human since its a result of mixing between humans and Neanderthals/Denisovians...but is there/was there a purely human version?

    Looking forward to the answer to your question.

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    Quote Originally Posted by davef View Post
    Yeah, i guess what makes it a human version is the fact that it's at least partially human since its a result of mixing between humans and Neanderthals/Denisovians...but is there/was there a purely human version?

    Looking forward to the answer to your question.
    Here's the reply from Insitome.

    if a trait lists you as the "human" version, it means you did not have the Neanderthal version of the trait (in science terms called a haplotype), and it was not the product of admixture. Whether Human or Neanderthal version, it is still the same DMD gene, and there are small differences in the DNA that allow us to identify ancestries. Genes listed in the bottom of the descriptions indicate which genes were tested. Thanks, and sorry for the delay in this reply.

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    1 members found this post helpful.
    My Results:
    1.2% (1.4% on Geno 2 Helix)
    HAIR
    - Pigmentation: Human
    SKIN
    - Sun Damage Repair: Human
    SPINE
    - Torso Shape: Human
    COGNITION
    - Learning: Neanderthal
    ENVIRONMENTAL REACTION
    - Fat Storage: Neanderthal
    - High altitude adaptation: Human
    IMMUNITY
    - Interpreting Immune Signal: Human
    - Pathogens Recognition: Neanderthal
    - Viral Immune Response: Neanderthal
    MUSCLE
    - Muscle Growth and Development: Human



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    Advisor Jovialis's Avatar
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    Quote Originally Posted by Salento View Post
    My Results:
    1.2% (1.4% on Geno 2 Helix)
    HAIR
    - Pigmentation: Human
    SKIN
    - Sun Damage Repair: Human
    SPINE
    - Torso Shape: Human
    COGNITION
    - Learning: Neanderthal
    ENVIRONMENTAL REACTION
    - Fat Storage: Neanderthal
    - High altitude adaptation: Human
    IMMUNITY
    - Interpreting Immune Signal: Human
    - Pathogens Recognition: Neanderthal
    - Viral Immune Response: Neanderthal
    MUSCLE
    - Muscle Growth and Development: Human



    Sent from my iPhone using Eupedia Forum
    Cool results! Once again, we are very similar. Interesting how NG had us both at 1.4%, and Insitome has us both at 1.2%

    I guess, we can say its within the 1.3% range. Nevertheless, Insitome is prioritized for neanderthal admixture, so I would be more inclined to believe them a bit more.

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    Spencer Wells of the Genographic Project is involved with Insitome.
    Hopefully all tests are performed with High Standard.


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    Quote Originally Posted by Salento View Post
    Spencer Wells of the Genographic Project is involved with Insitome.
    Hopefully all tests are performed with High Standard.


    Sent from my iPhone using Eupedia Forum


    1.3% is the average amount for the helix NG test. I wonder what Insitome considers to be the average Neanderthal DNA. Maybe I should message them for the answer.

    Edit:

    I sent them an e-mail regarding the questions about their methods of scaling, and what they use as their averages, for Neanderthal Admixture, vs the National Geographic test.
    Last edited by Jovialis; 09-08-17 at 01:57.

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    This was their response:


    The method we use to estimate of your Neanderthal and Denisovan percentages depends on particular population genetic assumptions. The qualitative presence (>0%) or absence (0.0%) of Neanderthal ancestry is assured by all calculation methods, but your quantitative result varies based on these assumptions. The models we use to calculate your percentage are informed by the latest science, and this means the percentage may change slightly as new scientific discoveries are made. Insitome uses the latest science, so you can rest assured that our estimates are the most up-to-date available. - Science team

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    Metabolism reveals the (r)evolutionary story behind your diet—how your genome has been tailored over millennia to the foods your ancestors ate, and what it means for you today. Changes in the human diet have resulted in changes in our own DNA. In the process of adopting new diets, we’ve adapted to them as well. Discover the next chapter in the story of you, Metabolism, to find out the truth behind why you are what you eat.

    https://www.helix.com/shop/ancestry
    You are what you eat. This Insight reveals the (r)evolutionary story behind your diet - how your genome has been tailored over the millennia to the foods your ancestors ate, and what it means for you today.

    http://insito.me/app/product/traits
    Looking into the genetics behind the body's metabolism is the next app Insitome is going to release eventually. It's suppose to assess how food our ancestors ate, contributed to how our bodies' work. I hope this will give some insight into ancient human origins from the paleolithic to the iron age.

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    I like that, and can't wait for such app.

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    Quote Originally Posted by LeBrok View Post
    I like that, and can't wait for such app.
    Me too, I think it should be able to give me a lot of insight. Even though Helix doesn't give out the raw data file, I think their platform is coming along nicely. However, it turns out I am prohibited from procuring health related DNA assessments. Apparently, there's a law against it in NJ, and NY. Nevertheless, the person I spoke to assured me I will have access to the metabolism app.

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    1 members found this post helpful.
    Quote Originally Posted by Jovialis View Post
    Me too, I think it should be able to give me a lot of insight. Even though Helix doesn't give out the raw data file, I think their platform is coming along nicely. However, it turns out I am prohibited from procuring health related DNA assessments. Apparently, there's a law against it in NJ, and NY. Nevertheless, the person I spoke to assured me I will have access to the metabolism app.
    I would love to have my metabolic DNA tested!! Believe it or not, I think many cases of mental disorders/diseases (ADHD, depression, etc) stem from metabolic issues such as not being able to process certain nutrients. I would guess that some of these metabolic issues can lead to toxins floating around in the bloodstream that can harm the brain, or limit your body's (including the brain) ability to use them, resulting in nutritional deficiencies.

    If the body's ability to utilize nutrients critical to brain functioning such as B-12 is limited, the brain is malnourished.

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    Quote Originally Posted by davef View Post
    I would love to have my metabolic DNA tested!! Believe it or not, I think many cases of mental disorders/diseases (ADHD, depression, etc) stem from metabolic issues such as not being able to process certain nutrients. I would guess that some of these metabolic issues can lead to toxins floating around in the bloodstream that can harm the brain, or limit your body's (including the brain) ability to use them, resulting in nutritional deficiencies.

    If the body's ability to utilize nutrients critical to brain functioning such as B-12 is limited, the brain is malnourished.
    I agree, diet is so fundamental to how one can operate in society, and manage stress or depression.

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    I don't understand the point to use the word human for homo sapiens but not to Neanderthal. If this was some archaic hominid admixture usually peak in some South African Mbuti that would be politically very incorrect word to use as.

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    Quote Originally Posted by curiouscat View Post
    I don't understand the point to use the word human for homo sapiens but not to Neanderthal. If this was some archaic hominid admixture usually peak in some South African Mbuti that would be politically very incorrect word to use as.
    It says modern Human though.

    Edit: Africans are also composites of other hominds as well. Most likely Homo Erectus.

    http://www.buffalo.edu/news/releases/2017/07/028.html

    Edit 2: I wonder how long it will be before they will be able to test other ancient hominids within people.
    Last edited by Jovialis; 16-08-17 at 03:15.

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