Eupedia Forums
Site NavigationEupedia Top > Eupedia Forum & Japan Forum
Results 1 to 6 of 6

Thread: Scientists discover gene controlling genetic recombination rates

  1. #1
    Moderator Achievements:
    Three FriendsTagger First Class1 year registered50000 Experience Points
    Awards:
    Master Tagger
    Jovialis's Avatar
    Join Date
    04-05-17
    Location
    New York City
    Posts
    2,801
    Points
    88,489
    Level
    92
    Points: 88,489, Level: 92
    Level completed: 55%, Points required for next Level: 861
    Overall activity: 99.3%

    Y-DNA haplogroup
    R1b1a1a2b1 (R-F1794)
    MtDNA haplogroup
    H6a1b

    Ethnic group
    Italian
    Country: United States



    2 out of 2 members found this post helpful.

    Scientists discover gene controlling genetic recombination rates

    Genetics is a crapshoot. During sexual reproduction, genes from both the mother and the father mix and mingle to produce a genetic combination unique to each offspring. In most cases, the chromosomes line up properly and crossover. In some unlucky cases, however, "selfish DNA" enters the mix, causing abnormal crossovers with deletions or insertions in chromosomes, which can manifest as birth defects.

    Scientists have long recognized that the exchange of genetic material by crossing over—known as recombination—is vital to natural selection. Yet some species display far more crossover than others. Why? Researchers hypothesize that crossover rates have evolved to balance the benefits of crossing over with the risks of selfish DNA.

    "There's a bit of a mystery being solved now about how certain molecular, biological, and genome phenomena have evolved in response to selfish genetic elements," says Daven Presgraves, a dean's professor of biology at the University of Rochester. "The role of natural selection in an ecological context is essentially a solved problem, but the role of natural selection in response to selfish genetic elements is still being worked out."

    Identifying a gene

    Presgraves and Ph.D. candidate Cara Brand recently accomplished an important milestone in learning about these evolutionary dynamics. By studying two species of fruit flies, they discovered a gene, MEI-218, that controls the rate of recombination. In a paper published in Current Biology, they explain how MEI-218 controls differences in the rate of crossing over between species and the evolutionary forces at play.

    "This is the first gene I know of that anyone has shown to be responsible for the evolution of recombination rates," Presgraves says.

    The team focused on two closely related species of fruit flies—Drosophila melanogaster and its sister species, Drosophila mauritiana—because large differences have evolved in their rates of recombination: D. mauritiana does about 1.5 times more crossing over than D. melanogaster. When they compared genes in the two different species, the researchers found that the DNA sequences of MEI-218 were extraordinarily different.

    The importance of genetic recombination

    "Natural selection works best when there's a diversity of genotypes to act upon," says Brand, the lead author of the paper. "Shuffling combinations of alleles through recombination generates the diversity upon which natural selection acts."

    Recombination is therefore important for two main reasons:

    Imagine two chromosomes with genes A and B. On one chromosome you might have a "good" (beneficial) A allele and a "bad" (deleterious) B allele. On the other chromosome you might have the opposite; a bad A allele and a good B allele. Which chromosome would be a better? "It's a mixed bag where one chromosome can't necessarily outcompete the other," Brand says. "Recombination can shuffle our allele combinations so that one chromosome can end up with the good A and B alleles together, while the other can get the bad A and B alleles together. Now when these chromosomes compete, the two good alleles will win out in future generations."
    We have combinations of alleles that are good in our current environment, but the environment is always changing. The good alleles that are adaptive and healthy now may not be so in the next generation. Recombination can shuffle these combinations of genes so that some will be bad and those offspring will die, but some will be good and these offspring will survive.
    "Recombination is important—it's not hard to convince anyone of that—but when we look across different species, we see that the rates of crossing over are different," Brand says. "Why increase or decrease the recombination rate?"

    The mystery of natural selection and selfish DNA

    There is no single ideal rate or distribution of crossovers, Brand says. Crossovers are necessary to produce viable offspring, but crossing over also has risks. Selfish DNA sequences known as transposons—repetitive genetic elements that do not seem to have benefits to their hosts—are distributed throughout the genome. Transposons are akin to viruses, but instead of injecting themselves in cells, they invade genetic material. If abnormal crossovers occur between transposons in different locations on the chromosomes, the chromosomes do not line up properly and important genes may be duplicated or deleted.

    Brand and Presgraves hypothesize that the change in recombination rates between D. mauritiana and D. melanogaster may have evolved because the species have different amounts of transposons in their genomes. The D. melanogaster genome has more transposons than D. mauritiana, so D. melanogaster may therefore have evolved a lower rate of crossing over in order to avoid the higher risk of harmful crossovers between transposons.

    This means, then, that the MEI-218 gene is constantly evolving to an ever-changing optimum. The evolution of MEI-218 is similar to genes involved in immunity, Presgraves says. "That should make some intuitive sense because genes involved in immunity are constantly adapting to the changing community pathogens that are challenging us all the time."

    Evolutionary biologists refer to these kinds of evolutionary dynamics as "evolutionary arms races" because, through positive natural selection, genes are chasing a constantly changing fitness optimum. "Maybe you just adapted, but a few generations from now you're not at the optimum anymore. You have to evolve again and again and again," Presgraves says.

    The MEI-218 gene has so far only been investigated in fruit flies, but the research into recombination has applications for humans. "During meiosis at least one crossover per chromosome, in general, is required to make sure the chromosomes separate properly," Brand says. "Either a lack of crossing over or crossing over in the wrong regions of the genome is what leads to many birth defects like Down Syndrome."



    Read more at: https://phys.org/news/2018-04-scient...ation.html#jCp


    Molecular Evolution at a Meiosis Gene Mediates Species Differences in the Rate and Patterning of Recombination

    Highlights


    Two Drosophila species evolved different rates and distributions of crossing over

    In transgenic flies, mei-217/mei-218 recapitulates much of the species difference

    The mei-217/mei-218 protein-coding sequence evolved by recurrent positive selection

    Differences in crossing over alter the genomic patterning of nucleotide variability


    Summary


    Crossing over between homologous chromosomes during meiosis repairs programmed DNA double-strand breaks, ensures proper segregation at meiosis I [1], shapes the genomic distribution of nucleotide variability in populations, and enhances the efficacy of natural selection among genetically linked sites [2]. Between closely related Drosophila species, large differences exist in the rate and chromosomal distribution of crossing over. Little, however, is known about the molecular genetic changes or population genetic forces that mediate evolved differences in recombination between species [3, 4]. Here, we show that a meiosis gene with a history of rapid evolution acts as a trans-acting modifier of species differences in crossing over. In transgenic flies, the dicistronic gene, mei-217/mei-218, recapitulates a large part of the species differences in the rate and chromosomal distribution of crossing over. These phenotypic differences appear to result from changes in protein sequence not gene expression. Our population genetics analyses show that the protein-coding sequence of mei-218, but not mei-217, has a history of recurrent positive natural selection. By modulating the intensity of centromeric and telomeric suppression of crossing over, evolution at mei-217/-218 has incidentally shaped gross differences in the chromosomal distribution of nucleotide variability between species. We speculate that recurrent bouts of adaptive evolution at mei-217/-218 might reflect a history of coevolution with selfish genetic elements.

    https://www.sciencedirect.com/scienc...410?via%3Dihub





  2. #2
    Advisor Achievements:
    VeteranThree Friends50000 Experience PointsRecommendation Second Class
    Awards:
    Posting Award
    Angela's Avatar
    Join Date
    02-01-11
    Posts
    15,305
    Points
    279,183
    Level
    100
    Points: 279,183, Level: 100
    Level completed: 0%, Points required for next Level: 0
    Overall activity: 99.6%


    Ethnic group
    Italian
    Country: USA - New York



    1 out of 1 members found this post helpful.
    Well, it seems that what might be beneficial for the species as a whole in the long term might turn out to be very harmful to an individual in the short term.

    It explains why perfectly healthy parents could give birth to a very compromised child, unfortunately.


    Non si fa il proprio dovere perchè qualcuno ci dica grazie, lo si fa per principio, per se stessi, per la propria dignità. Oriana Fallaci

  3. #3
    Regular Member Achievements:
    Veteran10000 Experience Points

    Join Date
    12-03-14
    Posts
    500
    Points
    10,821
    Level
    31
    Points: 10,821, Level: 31
    Level completed: 39%, Points required for next Level: 429
    Overall activity: 20.0%


    Country: Italy



    This one was just shared by F. Genomes. I found it interesting.
    http://blogs.discovermagazine.com/d-...ion-evolution/

  4. #4
    Regular Member Achievements:
    100 Experience Points

    Join Date
    29-07-19
    Posts
    12
    Points
    127
    Level
    1
    Points: 127, Level: 1
    Level completed: 77%, Points required for next Level: 23
    Overall activity: 26.0%


    Country: United States



    This actually surprises me a lot. I wonder what the implications are for future West Asian populations are (Kazakhstan, Uzbekistan, etc.).

  5. #5
    Regular Member Achievements:
    3 months registered500 Experience Points

    Join Date
    11-01-19
    Posts
    20
    Points
    606
    Level
    6
    Points: 606, Level: 6
    Level completed: 28%, Points required for next Level: 144
    Overall activity: 0%


    Country: China



    Very interesting. Thanks for sharing

  6. #6
    Regular Member Achievements:
    7 days registered
    Fegalevac's Avatar
    Join Date
    11-08-19
    Posts
    11
    Points
    75
    Level
    1
    Points: 75, Level: 1
    Level completed: 25%, Points required for next Level: 75
    Overall activity: 0%


    Country: Austria



    Important information that helped me.

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •