Eupedia Forums
Site NavigationEupedia Top > Eupedia Forum & Japan Forum
Results 1 to 4 of 4

Thread: ConStruct: New tool for examining genetic structure in populations

  1. #1
    Advisor Angela's Avatar
    Join Date
    02-01-11
    Posts
    21,692


    Ethnic group
    Italian
    Country: USA - New York



    ConStruct: New tool for examining genetic structure in populations

    More great work from Graham Coop:

    See:
    Gideon S. Bradburd, View ORCID ProfileGraham M. Coop and View ORCID ProfilePeter L. Ralph

    "
    Inferring Continuous and Discrete Population Genetic Structure Across Space"
    http://www.genetics.org/content/210/1/33

    "ABSTRACT A classic problem in population genetics is the characterization of discrete population structure in the presence ofcontinuous patterns of genetic differentiation. Especially when sampling is discontinuous, the use of clustering or assignmentmethods may incorrectly ascribe differentiation due to continuous processes (e.g., geographic isolation by distance) to discreteprocesses, such as geographic, ecological, or reproductive barriers between populations. This reflects a shortcoming of currentmethods for inferring and visualizing population structure when applied to genetic data deriving from geographically distributedpopulations. Here, we present a statistical framework for the simultaneous inference of continuous and discrete patterns ofpopulation structure. The method estimates ancestry proportions for each sample from a set of two-dimensional populationlayers, and, within each layer, estimates a rate at which relatedness decays with distance. This thereby explicitly addressesthe “clines versus clusters" problem in modeling population genetic variation, and remedies some of the overfitting to whichnonspatial models are prone. The method produces useful descriptions of structure in genetic relatedness in situations whereseparated, geographically distributed populations interact, as after a range expansion or secondary contact. We demonstratethe utility of this approach using simulations and by applying it to empirical datasets of poplars and black bears in North America."


    Non si fa il proprio dovere perchè qualcuno ci dica grazie, lo si fa per principio, per se stessi, per la propria dignità. Oriana Fallaci

  2. #2
    Regular Member Bosnian Boss's Avatar
    Join Date
    09-07-15
    Location
    California
    Posts
    32

    Y-DNA haplogroup
    I-M423
    MtDNA haplogroup
    J1C1

    Ethnic group
    Bosniak, Serb, Croat, Czech, German
    Country: USA - California



    Do you mind translating this into layman?

  3. #3
    Regular Member
    Join Date
    21-10-14
    Posts
    25


    Country: Mexico



    I don't recall seeing this tool referenced in any study since that publication. Has it been used for any study that has suddenly brought to light information not already known or data that couldn't be determined from other tools?

  4. #4
    Advisor Angela's Avatar
    Join Date
    02-01-11
    Posts
    21,692


    Ethnic group
    Italian
    Country: USA - New York



    It's been cited 160 times, not always in human population studies, but of course, genetics and the mathematics used to interpret genomes has a lot of cross-application. You're welcome to scroll through all 160 papers.

    Inferring continuous and discrete population genetic structure across space

    GS Bradburd, GM Coop, PL Ralph - Genetics, 2018 - academic.oup.com
    An important step in the analysis of genetic data is to describe and categorize natural
    variation. Individuals that live close together are, on average, more genetically similar than
    individuals sampled farther apart... A classic problem in population genetics is the
    characterization of discrete population structure in the presence of continuous patterns of
    genetic differentiation. Especially when sampling is discontinuous, the use of clustering or
    assignment methods may incorrectly ascribe differentiation due to continuous processes …

    Cite Cited by 160 Related articles All 13 versions

Similar Threads

  1. The genetic structure of Norway
    By Bygdedweller in forum Autosomal Genetics
    Replies: 6
    Last Post: 25-05-21, 14:46
  2. Tool that allows PCA with distant populations.
    By Henrique in forum Autosomal Genetics
    Replies: 0
    Last Post: 15-08-20, 19:57
  3. Population genetic structure of China
    By Angela in forum Autosomal Genetics
    Replies: 0
    Last Post: 08-10-18, 19:08
  4. Structure in populations in New Guinea
    By Angela in forum Autosomal Genetics
    Replies: 0
    Last Post: 15-09-17, 19:39
  5. Genetic Structure of France
    By Angela in forum Autosomal Genetics
    Replies: 12
    Last Post: 23-04-17, 00:15

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •