Eupedia Forums
Site NavigationEupedia Top > Eupedia Forum & Japan Forum
Results 1 to 4 of 4

Thread: Is "happiness" or a "sense of well being" genetically based?

  1. #1
    Advisor Achievements:
    VeteranThree Friends50000 Experience PointsRecommendation Second Class
    Awards:
    Posting Award
    Angela's Avatar
    Join Date
    02-01-11
    Posts
    15,538
    Points
    290,879
    Level
    100
    Points: 290,879, Level: 100
    Level completed: 0%, Points required for next Level: 0
    Overall activity: 99.6%


    Ethnic group
    Italian
    Country: USA - New York



    Is "happiness" or a "sense of well being" genetically based?

    The answer is yes, it's heritable to some degree, which is no surprise to me.

    I know people who are virtually always happy, when, from my subjective viewpoint it's totally unwarranted. :) Conversely, people are often very depressed for not very good reasons, imo.

    See:
    https://www.nature.com/articles/s41588-018-0320-8

    "We introduce two novel methods for multivariate genome-wide-association meta-analysis (GWAMA) of related traits that correct for sample overlap. A broad range of simulation scenarios supports the added value of our multivariate methods relative to univariate GWAMA. We applied the novel methods to life satisfaction, positive affect, neuroticism, and depressive symptoms, collectively referred to as the well-being spectrum (Nobs = 2,370,390), and found 304 significant independent signals. Our multivariate approaches resulted in a 26% increase in the number of independent signals relative to the four univariate GWAMAs and in an ~57% increase in the predictive power of polygenic risk scores. Supporting transcriptome- and methylome-wide analyses (TWAS and MWAS, respectively) uncovered an additional 17 and 75 independent loci, respectively. Bioinformatic analyses, based on gene expression in brain tissues and cells, showed that genes differentially expressed in the subiculum and GABAergic interneurons are enriched in their effect on the well-being spectrum."


    Non si fa il proprio dovere perchè qualcuno ci dica grazie, lo si fa per principio, per se stessi, per la propria dignità. Oriana Fallaci

  2. #2
    Regular Member Achievements:
    3 months registered500 Experience Points

    Join Date
    11-01-19
    Posts
    20
    Points
    606
    Level
    6
    Points: 606, Level: 6
    Level completed: 28%, Points required for next Level: 144
    Overall activity: 0%


    Country: China



    Search for
    "Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression."
    (I'm not allowed to post links yet)

    It presents a less convoluted approach to the same question. It's, frankly, a better study.

  3. #3
    Regular Member Achievements:
    Three FriendsRecommendation Second Class10000 Experience PointsVeteran
    Dibran's Avatar
    Join Date
    25-09-16
    Posts
    814
    Points
    12,582
    Level
    33
    Points: 12,582, Level: 33
    Level completed: 91%, Points required for next Level: 68
    Overall activity: 33.0%

    Y-DNA haplogroup
    R1a-L1029*
    MtDNA haplogroup
    H11a2*-146+

    Ethnic group
    Albanian/Gheg/Dibran/Okshtun
    Country: United States



    Quote Originally Posted by Angela View Post
    The answer is yes, it's heritable to some degree, which is no surprise to me.

    I know people who are virtually always happy, when, from my subjective viewpoint it's totally unwarranted. :) Conversely, people are often very depressed for not very good reasons, imo.

    See:
    https://www.nature.com/articles/s41588-018-0320-8

    "We introduce two novel methods for multivariate genome-wide-association meta-analysis (GWAMA) of related traits that correct for sample overlap. A broad range of simulation scenarios supports the added value of our multivariate methods relative to univariate GWAMA. We applied the novel methods to life satisfaction, positive affect, neuroticism, and depressive symptoms, collectively referred to as the well-being spectrum (Nobs = 2,370,390), and found 304 significant independent signals. Our multivariate approaches resulted in a 26% increase in the number of independent signals relative to the four univariate GWAMAs and in an ~57% increase in the predictive power of polygenic risk scores. Supporting transcriptome- and methylome-wide analyses (TWAS and MWAS, respectively) uncovered an additional 17 and 75 independent loci, respectively. Bioinformatic analyses, based on gene expression in brain tissues and cells, showed that genes differentially expressed in the subiculum and GABAergic interneurons are enriched in their effect on the well-being spectrum."
    Quote Originally Posted by Yinwang888 View Post
    Search for
    "Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression."
    (I'm not allowed to post links yet)

    It presents a less convoluted approach to the same question. It's, frankly, a better study.

    This one?

    https://www.nature.com/articles/s41588-018-0090-3

  4. #4
    Regular Member Achievements:
    3 months registered500 Experience Points

    Join Date
    11-01-19
    Posts
    20
    Points
    606
    Level
    6
    Points: 606, Level: 6
    Level completed: 28%, Points required for next Level: 144
    Overall activity: 0%


    Country: China



    Yes, exactly. It's a very interesting paper on the subject. The OP paper is also good, but I found this one easier to understand. Thanks for providing link. There should be a free version on bioarxiv as well.

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •