Angela
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It's time to stop the fat shaming. A good part of all this, thinness and its opposite, extreme obesity, is genetics, as should have been obvious.
Yes, people have atrocious diets, especially in some countries, and eat too much for their level of activity, but some individuals, and more in some countries than in others, can eat anything they want and never get fat, and some can't be really thin unless they exercise inhuman restraint and eat almost nothing.
It's not fair, but there it is...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007603
"Obesity-associated disorders are amongst the leading causes of morbidity and mortality worldwide. Most genome-wide association studies (GWAS) have focused on body mass index (BMI = weight in Kg divided by height squared (m2)) and obesity, but to date no genetic association study testing thin and healthy individuals has been performed. In this study, we recruited a first of its kind cohort of 1,471 clinically ascertained thin and healthy individuals and contrasted the genetic architecture of the trait with that of severe early onset obesity. We show that thinness, like obesity, is a heritable trait with a polygenic component. In a GWAS of persistent healthy thinness vs. severe obesity with a total sample size of 2,927, we are able to find evidence of association in loci that have only been recently discovered using large cohorts with >40,000 individuals. We also find a novel BMI-associated locus at PKHD1 in UK Biobank highlighted by our association study. This work illustrates the value and increased power brought upon by using clinically ascertained extremes to study complex traits and provides a valuable resource on which to study resistance to obesity in an increasingly obesogenic environment."
I think some of these genes are already known: 23andme tests for some of them.
Yes, people have atrocious diets, especially in some countries, and eat too much for their level of activity, but some individuals, and more in some countries than in others, can eat anything they want and never get fat, and some can't be really thin unless they exercise inhuman restraint and eat almost nothing.
It's not fair, but there it is...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007603
"Obesity-associated disorders are amongst the leading causes of morbidity and mortality worldwide. Most genome-wide association studies (GWAS) have focused on body mass index (BMI = weight in Kg divided by height squared (m2)) and obesity, but to date no genetic association study testing thin and healthy individuals has been performed. In this study, we recruited a first of its kind cohort of 1,471 clinically ascertained thin and healthy individuals and contrasted the genetic architecture of the trait with that of severe early onset obesity. We show that thinness, like obesity, is a heritable trait with a polygenic component. In a GWAS of persistent healthy thinness vs. severe obesity with a total sample size of 2,927, we are able to find evidence of association in loci that have only been recently discovered using large cohorts with >40,000 individuals. We also find a novel BMI-associated locus at PKHD1 in UK Biobank highlighted by our association study. This work illustrates the value and increased power brought upon by using clinically ascertained extremes to study complex traits and provides a valuable resource on which to study resistance to obesity in an increasingly obesogenic environment."
I think some of these genes are already known: 23andme tests for some of them.