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Thread: 550,000-year-old Neanderthal DNA

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    2 out of 2 members found this post helpful.

    550,000-year-old Neanderthal DNA

    Traces of prehistoric human DNA have been found in caves without bones in an advance that could shed new light on human history and evolution.

    While many prehistoric sites in Europe and Asia contain tools and other human-made artefacts, skeletal remains of ancient humans are scarce.

    Because of this, the DNA found between cracks of rock could help us better understand how early humans such as Neanderthals and Denisovans evolved

    'We know that several components of sediments can bind DNA', said Matthias Meyer of the Max Planck Institute for Evolutionary Anthropology.

    'We therefore decided to investigate whether hominin DNA may survive in sediments at archaeological sites known to have been occupied by ancient hominins.'

    The researchers excavated seven archaeological sites in Belgium, Croatia, France, Russia and Spain.

    https://www.dailymail.co.uk/sciencet...out-bones.html


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    DNA from extinct humans discovered in cave sediments - press release

    Neandertal and Denisovan DNA from Pleistocene sediments - original paper

    This is all from 2017, I don't remember it being posted here though.

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    yes, realised that too, it's old

    I wonder wether this 550 ka Neanderthal has been confirmed though. Was it branched off from Denisovan yet?

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    "The project first sequenced the entire genome of a Neanderthal in 2013 by extracting it from the phalanx bone of a 50,000-year-old Siberian Neanderthal.[10]
    Among the genes shown to differ between present-day humans and Neanderthals were RPTN, SPAG17, CAN15, TTF1, FOXP2 and PCD16.[11]
    A visualisation map of the reference modern-human containing the genome regions with high degree of similarity or with novelty according to a Neanderthal of 50 ka[10] has been built by Pratas et al.[12]​"

    If this is confirmed a Neanderthal, that would push us 11x zoom, no?
    “Man cannot live without a permanent trust in something indestructible in himself, and at the same time that indestructible something as well as his trust in it may remain permanently concealed from him.”

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    Quote Originally Posted by Archetype0ne View Post
    "The project first sequenced the entire genome of a Neanderthal in 2013 by extracting it from the phalanx bone of a 50,000-year-old Siberian Neanderthal.[10]
    Among the genes shown to differ between present-day humans and Neanderthals were RPTN, SPAG17, CAN15, TTF1, FOXP2 and PCD16.[11]
    A visualisation map of the reference modern-human containing the genome regions with high degree of similarity or with novelty according to a Neanderthal of 50 ka[10] has been built by Pratas et al.[12]​"

    If this is confirmed a Neanderthal, that would push us 11x zoom, no?
    ok
    do you have a link?

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    https://link.springer.com/chapter/10...319-58838-4_26

    Best I can do, hope it helps.

    "Abstract

    Species-specific DNA regions are segments that are unique or share high dissimilarity relatively to close species. Their discovery is important, because they allow the localization of evolutionary traits that are often related to novel functionalities and, sometimes, diseases.
    We have detected distinct DNA regions specific in the modern human, when compared to a Neanderthal high-quality genome sequence obtained from a bone of a Siberian woman. The bone is around 50,000 years old and the DNA raw data totalizes more than 418 GB. Since the data size required for localizing efficiently such events is very high, it is not practical to store the model on a table or hash table. Thus, we propose a probabilistic method to map and visualize those regions. The time complexity of the method is linear. The computational tool is available at http://pratas.github.io/chester."


    Authors

    Authors and affiliations

    Diogo Pratas

    Morteza Hosseini

    Raquel M. Silva

    Armando J. Pinho

    Paulo J. S. G. Ferreira






    Conference paper First Online: 12 May 2017
    3Mentions
    4Readers
    885Downloads


    Part of the Lecture Notes in Computer Science book series (LNCS, volume 10255)

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    Thanks for your post!

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    Can you add some information?

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