It's definitely the case that the adolescent years into the early 20's is when a lot of mental health issues and schizophrenia, in particular, surfaces, often in conjunction with some traumatic event, which can range from the death of a parent, a bad break-up, perhaps a traumatic sexual experience, etc.. It's as if the stress acts upon the latent susceptibility. It happened to a distant cousin of mine in Italy, after his girlfriend left him. He committed suicide.
This is precisely the time when young people experiment with drugs. I personally believe they will be shown to be a causative factor in the expression of that susceptibility.
It's also the time when our culture pushes children out the door and into university settings. Some of them, imo, aren't ready for the freedom, the isolation, etc. I know I'm in the minority about that.