YSTR mutation rates and TMRCA through Italian pedigrees

Angela

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See: Boattini et al

https://www.nature.com/articles/s41598-019-45398-3#disqus_thread

"In the population genomics era, the study of Y-chromosome variability is still of the greatest interest for several fields ranging from molecular anthropology to forensics and genetic genealogy. In particular, mutation rates of Y-chromosomal Short Tandem Repeats markers (Y-STRs) are key parameters for different interdisciplinary applications. Among them, testing the patrilineal relatedness between individuals and calculating their Time of Most Recent Common Ancestors (TMRCAs) are of the utmost importance. To provide new valuable estimates and to address these issues, we typed 47 Y-STRs (comprising Yfiler, PowerPlex23 and YfilerPlus loci, the recently defined Rapidly Mutating [RM] panel and 11 additional markers often used in genetic genealogical applications) in 135 individuals belonging to 66 deep-rooting paternal genealogies from Northern Italy. Our results confirmed that the genealogy approach is an effective way to obtain reliable Y-STR mutation rate estimates even with a limited number of samples. Moreover, they showed that the impact of multi-step mutations and backmutations is negligible within the temporal scale usually adopted by forensic and genetic genealogy analyses. We then detected a significant association between the number of mutations within genealogies and observed TMRCAs. Therefore, we compared observed and expected TMRCAs by implementing a Bayesian procedure originally designed by Walsh (2001) and showed that the method yields a good performance (up to 96.72%), especially when using the Infinite Alleles Model (IAM)."
 
Supplementary Table S1. Absolute and relative frequencies of the observed haplogroups in the new sample of 135 individuals belonging to 66 paternal lineages from Emilia Romagna and Veneto.

HAPLOGROUPABS. FREQ.
E-V135
E-M341
G2a-U12
G2a-U89
I1-M2535
I1-P1091
J1-P584
J2a-M4103
J2b-M24112
LT-P3261
T-L13110
R1a-M1986
R1b-M2694
R1b-M4126
R1b-Z3811
R1b-L482
R1b-P3124
R1b-Z1952
R1b-U15233
R1b-L224



I have never seen a sample of a person with haplo. LT-P326 only

interesting that there are 10 of my branch
 
Supplementary Table S1. Absolute and relative frequencies of the observed haplogroups in the new sample of 135 individuals belonging to 66 paternal lineages from Emilia Romagna and Veneto.

HAPLOGROUPABS. FREQ.
E-V135
E-M341
G2a-U12
G2a-U89
I1-M2535
I1-P1091
J1-P584
J2a-M4103
J2b-M24112
LT-P3261
T-L13110
R1a-M1986
R1b-M2694
R1b-M4126
R1b-Z3811
R1b-L482
R1b-P3124
R1b-Z1952
R1b-U15233
R1b-L224



I have never seen a sample of a person with haplo. LT-P326 only

interesting that there are 10 of my branch

LT-P326 will be looked at my some learned people and project people ( via facebook ) ...........they state he could be T2-PH110 , which would make 4 samples only so far......Germany, Armenia and the Bhutan are the others
 

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