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Thread: YSTR mutation rates and TMRCA through Italian pedigrees

  1. #1
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    YSTR mutation rates and TMRCA through Italian pedigrees

    See: Boattini et al

    https://www.nature.com/articles/s415...#disqus_thread

    "In the population genomics era, the study of Y-chromosome variability is still of the greatest interest for several fields ranging from molecular anthropology to forensics and genetic genealogy. In particular, mutation rates of Y-chromosomal Short Tandem Repeats markers (Y-STRs) are key parameters for different interdisciplinary applications. Among them, testing the patrilineal relatedness between individuals and calculating their Time of Most Recent Common Ancestors (TMRCAs) are of the utmost importance. To provide new valuable estimates and to address these issues, we typed 47 Y-STRs (comprising Yfiler, PowerPlex23 and YfilerPlus loci, the recently defined Rapidly Mutating [RM] panel and 11 additional markers often used in genetic genealogical applications) in 135 individuals belonging to 66 deep-rooting paternal genealogies from Northern Italy. Our results confirmed that the genealogy approach is an effective way to obtain reliable Y-STR mutation rate estimates even with a limited number of samples. Moreover, they showed that the impact of multi-step mutations and backmutations is negligible within the temporal scale usually adopted by forensic and genetic genealogy analyses. We then detected a significant association between the number of mutations within genealogies and observed TMRCAs. Therefore, we compared observed and expected TMRCAs by implementing a Bayesian procedure originally designed by Walsh (2001) and showed that the method yields a good performance (up to 96.72%), especially when using the Infinite Alleles Model (IAM)."


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    Y-DNA haplogroup
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    2 out of 2 members found this post helpful.
    Supplementary Table S1. Absolute and relative frequencies of the observed haplogroups in the new sample of 135 individuals belonging to 66 paternal lineages from Emilia Romagna and Veneto.

    HAPLOGROUP ABS. FREQ.
    E-V13 5
    E-M34 1
    G2a-U1 2
    G2a-U8 9
    I1-M253 5
    I1-P109 1
    J1-P58 4
    J2a-M410 3
    J2b-M241 12
    LT-P326 1
    T-L131 10
    R1a-M198 6
    R1b-M269 4
    R1b-M412 6
    R1b-Z381 1
    R1b-L48 2
    R1b-P312 4
    R1b-Z195 2
    R1b-U152 33
    R1b-L2 24



    I have never seen a sample of a person with haplo. LT-P326 only

    interesting that there are 10 of my branch
    Fathers mtdna T2b17
    Grandfather mtdna T1a1e
    Sons mtdna K1a4o
    Mum paternal line R1b-S8172
    Grandmum paternal side I1d1-P109
    Wife paternal line R1a-Z282

  3. #3
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    Y-DNA haplogroup
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    Quote Originally Posted by torzio View Post
    Supplementary Table S1. Absolute and relative frequencies of the observed haplogroups in the new sample of 135 individuals belonging to 66 paternal lineages from Emilia Romagna and Veneto.

    HAPLOGROUP ABS. FREQ.
    E-V13 5
    E-M34 1
    G2a-U1 2
    G2a-U8 9
    I1-M253 5
    I1-P109 1
    J1-P58 4
    J2a-M410 3
    J2b-M241 12
    LT-P326 1
    T-L131 10
    R1a-M198 6
    R1b-M269 4
    R1b-M412 6
    R1b-Z381 1
    R1b-L48 2
    R1b-P312 4
    R1b-Z195 2
    R1b-U152 33
    R1b-L2 24



    I have never seen a sample of a person with haplo. LT-P326 only

    interesting that there are 10 of my branch
    LT-P326 will be looked at my some learned people and project people ( via facebook ) ...........they state he could be T2-PH110 , which would make 4 samples only so far......Germany, Armenia and the Bhutan are the others

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