Dating Genomic Variants and Shared Ancestry in Populations

Angela

Elite member
Messages
21,823
Reaction score
12,325
Points
113
Ethnic group
Italian
This is something I think we're going to be hearing a lot about in the future. Very exciting!

See:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000586

I wonder how many pending papers are being looked at again in light of this new method. :)

"
[h=2]Abstract[/h]The origin and fate of new mutations within species is the fundamental process underlying evolution. However, while much attention has been focused on characterizing the presence, frequency, and phenotypic impact of genetic variation, the evolutionary histories of most variants are largely unexplored. We have developed a nonparametric approach for estimating the date of origin of genetic variants in large-scale sequencing data sets. The accuracy and robustness of the approach is demonstrated through simulation. Using data from two publicly available human genomic diversity resources, we estimated the age of more than 45 million single-nucleotide polymorphisms (SNPs) in the human genome and release the Atlas of Variant Age as a public online database. We characterize the relationship between variant age and frequency in different geographical regions and demonstrate the value of age information in interpreting variants of functional and selective importance. Finally, we use allele age estimates to power a rapid approach for inferring the ancestry shared between individual genomes and to quantify genealogical relationships at different points in the past, as well as to describe and explore the evolutionary history of modern human populations.'
 

This thread has been viewed 4325 times.

Back
Top