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Thread: The science behind Covid-19 - All you need to know

  1. #51
    Regular Member Duarte's Avatar
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    Quote Originally Posted by Angela View Post
    APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

    Not one I would have predicted, that's for sure...

    https://www.medrxiv.org/content/10.1....07.20094409v2

    The apolipoprotein E (ApoE) gene makes a protein which, when combined with fat, becomes a lipoprotein. The lipoprotein ApoE is a very low-density lipoprotein, responsible in part for removing cholesterol from the bloodstream. Variations in ApoE affect cholesterol metabolism, which in turn alter your chances of having heart disease and in particular a heart attack or a stroke. Variations in ApoE are also associated with altered odds of having Alzheimer's disease and other diseases.
    There are three relatively common allelic variants of ApoE, as defined by two SNPs, rs429358 and rs7412 known as ApoE-ε2, ApoE-ε3, and ApoE-ε4. The proteins produced by these genes are called ApoE2, ApoE3, and ApoE4. The most common variant overall is the "standard" ApoE-ε3, and therefore more people inherited one ApoE-ε3 from each parent than any other of the possible pairs of variants. Note that each of these types can actually have additional changes too, so there are different subtypes as well.
    Common name Genoset Magnitude rs429358 rs7412 Comment
    Apo-ε1/ε1 gs267 6 (C;C) (T;T) the rare missing allele
    Apo-ε1/ε2 gs271 2.5 (C;T) (T;T)
    Apo-ε1/ε3 gs270 2.6 (C;T) (C;T) ambiguous ε2/ε4 or ε1/ε3
    Apo-ε2/ε4 gs270 2.6 (C;T) (C;T) ambiguous ε2/ε4 or ε1/ε3
    Apo-ε1/ε4 gs272 2.5 (C;C) (C;T)
    Apo-ε2/ε2 gs268 4 (T;T) (T;T) good; lowest risk
    Apo-ε2/ε3 gs269 2 (T;T) (C;T)
    Apo-ε3/ε3 gs246 2 (T;T) (C;C) the most common
    Apo-ε3/ε4 gs141 3 (C;T) (C;C)
    Apo-ε4/ε4 gs216 6 (C;C) (C;C) ~11x increased Alzheimer's risk


    A rare form of the ApoE3 allele, rs121918393, also known as the Christchurch (R136S) mutation, appears to convey a significant amount of resistance to PSEN1-based form of autosomal dominant Alzheimer’s, according to a 2019 study.[1]

    There's more. Ancestry apparently does a lousy job with this and the results might be inaccurate.

    For me:

    rs429358:TT

    rs7412:CT

    Well, I guess I'm E2/E3.

    Not the worst.

    Another bad one:rs4420638
    I'm AA. GG is trouble.

    I wonder if this is about whether it affects your heart or just gives you pneumonia.

    At any rate, take it all with a grain of salt. This is not yet exact science.
    Me:

    # rsid chromosome position genotype
    rs429358 19 45411941 CT
    rs7412 19 45412079 CC

    Apo-E3/E4 - Magnitude 3

    Average Risk or Low risk ???

    PS: rs121918393 missing from my raw data.

  2. #52
    Advisor Angela's Avatar
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    Quote Originally Posted by Duarte View Post
    Me:

    # rsid chromosome position genotype
    rs429358 19 45411941 CT
    rs7412 19 45412079 CC

    Apo-E3/E4 - Magnitude 3

    Average Risk or Low risk ???
    Unfortunately, they don't categorize our risk, but given we get 3/4 "good" alleles, I'd say maybe at least "average"?

    Did you check the last snp?

    I know now why 23andme says slightly elevated risk of Alzheimer's: one damn "bad" version. Out of 9 children in my father's family who lived to middle age only one got Alzheimers. I guess through the roll of the genetic dice she somehow got a lot of the "bad" version.


    Non si fa il proprio dovere perchè qualcuno ci dica grazie, lo si fa per principio, per se stessi, per la propria dignità. Oriana Fallaci

  3. #53
    Regular Member Duarte's Avatar
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    Quote Originally Posted by Angela View Post
    Unfortunately, they don't categorize our risk, but given we get 3/4 "good" alleles, I'd say maybe at least "average"?

    Did you check the last snp?

    I know now why 23andme says slightly elevated risk of Alzheimer's: one damn "bad" version. Out of 9 children in my father's family who lived to middle age only one got Alzheimers. I guess through the roll of the genetic dice she somehow got a lot of the "bad" version.
    rs121918393 is missing from my raw data.
    rs4420638 19 45422946 AG

    Maybe all these are not too bad for me, I don't know

    PS: My father died with Alzheimer Disease at 84 years age.

  4. #54
    Advisor Angela's Avatar
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    Quote Originally Posted by Duarte View Post
    rs121918393 is missing from my raw data.
    rs4420638 19 45422946 AG

    Maybe all these are not too bad for me, I don't know

    PS: My father died with Alzheimer Disease at 84 years age.
    I don't think your results are "risky" at all.

    Yes, that's about when my aunt died of it.

    I want to emphasize this is speculative. As they point out in SNPedia, they are finding new snps all the time which swing the pendulum one way or another by modulating the effects of these particular snps.

  5. #55
    Advisor Angela's Avatar
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    Quote Originally Posted by Angela View Post
    I don't think your results are "risky" at all.

    Yes, that's about when my aunt died of it.

    I want to emphasize this is speculative. As they point out in SNPedia, they are finding new snps all the time which swing the pendulum one way or another by modulating the effects of these particular snps.
    For some reason they can't find my husband's rs429358

    APOE rs7412 45412079 C or T C / C

    intergenic rs4420638 45422946 A or G A / A


    That's it; I don't want to make myself or anyone else crazy over something that may or may not be true.

  6. #56
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    2 members found this post helpful.
    ... sorry for your loss ...


    23andme V5 Raw-Data

    rs429358 TT

    rs7412 CC

    ... APOE E3/E3

  7. #57
    Advisor Angela's Avatar
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    2 members found this post helpful.
    Quote Originally Posted by Salento View Post
    ... sorry for your loss ...
    23andme V5 Raw-Data
    rs429358 TT
    rs7412 CC
    ... APOE E3/E3
    For myself, they're all gone, my father and all his brothers and sisters in the last 20 years or so, although they all lived relatively long lives, all reaching into their 80s except my father. (Meanwhile, I have great aunts in Italy in their mid 90s. Come back to aria tua one of them used to say to me.)

    It's very sad making, particularly my parents, of course, but also my aunts and uncles. My nostalgia for my youth, when we would all gather together, with all my myriad cousins, is like a knife in my heart. When the last of them went, this particular aunt, it felt lonely, you know, and a bit scary. I'm definitely the adult now. :)

    There's an old American movie called "How Green Was My Valley" which captures this kind of feeling like no other. I've seen it probably a dozen times and it reduces me to tears each and every time. John Ford directed it and the actors were all top notch as well.

  8. #58
    Regular Member Duarte's Avatar
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    2 members found this post helpful.
    Quote Originally Posted by Salento View Post
    ... sorry for your loss ...
    23andme V5 Raw-Data
    rs429358 TT
    rs7412 CC
    ... APOE E3/E3
    @Salento


    @Angela
    My condolences Angela

  9. #59
    Regular Member Salento's Avatar
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    @Angela ...very sorry ....

    @Duarte ... I’ll totally outlive you

  10. #60
    Regular Member Duarte's Avatar
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    1 members found this post helpful.
    Quote Originally Posted by Salento View Post
    @Angela ...very sorry ....

    @Duarte ... I’ll totally outlive you

  11. #61
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    Quote Originally Posted by Angela View Post
    For myself, they're all gone, my father and all his brothers and sisters in the last 20 years or so, although they all lived relatively long lives, all reaching into their 80s except my father. (Meanwhile, I have great aunts in Italy in their mid 90s. Come back to aria tua one of them used to say to me.)
    It's very sad making, particularly my parents, of course, but also my aunts and uncles. My nostalgia for my youth, when we would all gather together, with all my myriad cousins, is like a knife in my heart. When the last of them went, this particular aunt, it felt lonely, you know, and a bit scary. I'm definitely the adult now. :)
    There's an old American movie called "How Green Was My Valley" which captures this kind of feeling like no other. I've seen it probably a dozen times and it reduces me to tears each and every time. John Ford directed it and the actors were all top notch as well.
    delete post
    Last edited by italouruguayan; 01-06-20 at 22:24.

  12. #62
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    See:

    Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19
    https://www.nature.com/articles/s41436-020-01077-7

  13. #63
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    Bill Gates statements do not sound convincing at all.

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