The science behind Covid-19 - All you need to know

[Duarte]

APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

Not one I would have predicted, that's for sure...

https://www.medrxiv.org/content/10.1....07.20094409v2

The apolipoprotein E (ApoE) gene makes a protein which, when combined with fat, becomes a lipoprotein. The lipoprotein ApoE is a very low-density lipoprotein, responsible in part for removing cholesterol from the bloodstream. Variations in ApoE affect cholesterol metabolism, which in turn alter your chances of having heart disease and in particular a heart attack or a stroke. Variations in ApoE are also associated with altered odds of having Alzheimer's disease and other diseases.
There are three relatively common allelic variants of ApoE, as defined by two SNPs, rs429358 and rs7412 known as ApoE-ε2, ApoE-ε3, and ApoE-ε4. The proteins produced by these genes are called ApoE2, ApoE3, and ApoE4. The most common variant overall is the "standard" ApoE-ε3, and therefore more people inherited one ApoE-ε3 from each parent than any other of the possible pairs of variants. Note that each of these types can actually have additional changes too, so there are different subtypes as well.

Common name	Genoset	Magnitude	rs429358	rs7412	Comment
Apo-ε1/ε1	gs267	6	(C;C)	(T;T)	the rare missing allele
Apo-ε1/ε2	gs271	2.5	(C;T)	(T;T)
Apo-ε1/ε3	gs270	2.6	(C;T)	(C;T)	ambiguous ε2/ε4 or ε1/ε3
Apo-ε2/ε4	gs270	2.6	(C;T)	(C;T)	ambiguous ε2/ε4 or ε1/ε3
Apo-ε1/ε4	gs272	2.5	(C;C)	(C;T)
Apo-ε2/ε2	gs268	4	(T;T)	(T;T)	good; lowest risk
Apo-ε2/ε3	gs269	2	(T;T)	(C;T)
Apo-ε3/ε3	gs246	2	(T;T)	(C;C)	the most common
Apo-ε3/ε4	gs141	3	(C;T)	(C;C)
Apo-ε4/ε4	gs216	6	(C;C)	(C;C)	~11x increased Alzheimer's risk

A rare form of the ApoE3 allele, rs121918393, also known as the Christchurch (R136S) mutation, appears to convey a significant amount of resistance to PSEN1-based form of autosomal dominant Alzheimer’s, according to a 2019 study.[1]

There's more. Ancestry apparently does a lousy job with this and the results might be inaccurate.

For me:

rs429358:TT

rs7412:CT

Well, I guess I'm E2/E3.

Not the worst.

Another bad one:rs4420638
I'm AA. GG is trouble.

I wonder if this is about whether it affects your heart or just gives you pneumonia.

At any rate, take it all with a grain of salt. This is not yet exact science.

Me:

# rsid	chromosome	position	genotype
rs429358	19	45411941	CT
rs7412	19	45412079	CC

Apo-E3/E4 - Magnitude 3

Average Risk or Low risk ???

PS: rs121918393 missing from my raw data.

[Angela]

Me:

# rsid	chromosome	position	genotype
rs429358	19	45411941	CT
rs7412	19	45412079	CC

Apo-E3/E4 - Magnitude 3

Average Risk or Low risk ???

Unfortunately, they don't categorize our risk, but given we get 3/4 "good" alleles, I'd say maybe at least "average"?

Did you check the last snp?

I know now why 23andme says slightly elevated risk of Alzheimer's: one damn "bad" version. Out of 9 children in my father's family who lived to middle age only one got Alzheimers. I guess through the roll of the genetic dice she somehow got a lot of the "bad" version.

[Duarte]

Unfortunately, they don't categorize our risk, but given we get 3/4 "good" alleles, I'd say maybe at least "average"?

Did you check the last snp?

I know now why 23andme says slightly elevated risk of Alzheimer's: one damn "bad" version. Out of 9 children in my father's family who lived to middle age only one got Alzheimers. I guess through the roll of the genetic dice she somehow got a lot of the "bad" version.

rs121918393 is missing from my raw data.

rs4420638

19

45422946

AG

Maybe all these are not too bad for me, I don't know

PS: My father died with Alzheimer Disease at 84 years age.

[Angela]

rs121918393 is missing from my raw data.

rs4420638

19

45422946

AG

Maybe all these are not too bad for me, I don't know

PS: My father died with Alzheimer Disease at 84 years age.

I don't think your results are "risky" at all.

Yes, that's about when my aunt died of it.

I want to emphasize this is speculative. As they point out in SNPedia, they are finding new snps all the time which swing the pendulum one way or another by modulating the effects of these particular snps.

[Angela]

I don't think your results are "risky" at all.

Yes, that's about when my aunt died of it.

I want to emphasize this is speculative. As they point out in SNPedia, they are finding new snps all the time which swing the pendulum one way or another by modulating the effects of these particular snps.

For some reason they can't find my husband's rs429358

APOE

rs7412

45412079

C or T

C / C

intergenic

rs4420638

45422946

A or G

A / A

That's it; I don't want to make myself or anyone else crazy over something that may or may not be true.

[Salento]

... sorry for your loss ...


23andme V5 Raw-Data

rs429358 TT

rs7412 CC

... APOE E3/E3

[Angela]

... sorry for your loss ...
23andme V5 Raw-Data
rs429358 TT
rs7412 CC
... APOE E3/E3

For myself, they're all gone, my father and all his brothers and sisters in the last 20 years or so, although they all lived relatively long lives, all reaching into their 80s except my father. (Meanwhile, I have great aunts in Italy in their mid 90s. Come back to aria tua one of them used to say to me.)

It's very sad making, particularly my parents, of course, but also my aunts and uncles. My nostalgia for my youth, when we would all gather together, with all my myriad cousins, is like a knife in my heart. When the last of them went, this particular aunt, it felt lonely, you know, and a bit scary. I'm definitely the adult now. :)

There's an old American movie called "How Green Was My Valley" which captures this kind of feeling like no other. I've seen it probably a dozen times and it reduces me to tears each and every time. John Ford directed it and the actors were all top notch as well.

[Duarte]

... sorry for your loss ...
23andme V5 Raw-Data
rs429358 TT
rs7412 CC
... APOE E3/E3

@Salento


@Angela
My condolences Angela

[Salento]

@Angela ...very sorry ....

@Duarte ... I’ll totally outlive you

[Duarte]

@Angela ...very sorry ....

@Duarte ... I’ll totally outlive you

[italouruguayan]

For myself, they're all gone, my father and all his brothers and sisters in the last 20 years or so, although they all lived relatively long lives, all reaching into their 80s except my father. (Meanwhile, I have great aunts in Italy in their mid 90s. Come back to aria tua one of them used to say to me.)
It's very sad making, particularly my parents, of course, but also my aunts and uncles. My nostalgia for my youth, when we would all gather together, with all my myriad cousins, is like a knife in my heart. When the last of them went, this particular aunt, it felt lonely, you know, and a bit scary. I'm definitely the adult now. :)
There's an old American movie called "How Green Was My Valley" which captures this kind of feeling like no other. I've seen it probably a dozen times and it reduces me to tears each and every time. John Ford directed it and the actors were all top notch as well.

delete post

[Regio X]

See:

Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19
https://www.nature.com/articles/s41436-020-01077-7

[Pqueens]

Bill Gates statements do not sound convincing at all.