Autosomal genetics of Brazilians (Epigem study)

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The EPIGEN-Brazil initiative is a strategic project of the Brazilian Ministry of Health, and is the largest Latin-American initiative for the study of human genetic diversity. It integrates two important Brazilian scientific traditions: Public Health and Human Population Genetics. In the context of the results of the EPIGEN-Brazil Project, we discuss how population genetics studies contribute to understand the process of crossbreed in Brazil, and its implications in Public Health. We show how the high genomic resolution of the EPIGEN-Brazil Project and the state-of-the-art computational methodologies allowed new inferences on the origin and dynamics of crossbreed, as well as to understand how the Brazilian social history influenced the genetic structure of this population.


Federal University of Minas Gerais. Institute of Biological Sciences. Department of General Biology. Belo Horizonte, MG, Brazil.
Federal university of Bahia. Institute of Collective Health. Salvador, BA, Brazil
Federal University of Pelotas. Graduate Program in Epidemiology. Pelotas, RGS, Brazil.
University of Sao Paulo. Heart Institute. São Paulo, SP, Brazil.
Oswaldo Cruz Foundation. Rene Rachou Research Institute. Belo Horizonte, MG, Brazil.


From available data on 6,497 individuals from the three so-called cohorts that are part of the EPIGEN-Brazil initiative with scientists led by Eduardo Tarazona Santos, professor at the Institute of Biological Sciences at the Federal University of Minas Gerais (UFMG), they identified how much of the genome of each of them has a European, African or Native American (Amerindian) origin.


Northeast Region:
As expected, the population genes of the first cohort - 1,309 individuals from Salvador (BA) - have a great African ancestry (50.8%), followed by the European (42.9%) and Amerindian (6.4%).


Southeast region:
In the second cohort, composed of 1,442 people from the city of Bambuí, Minas Gerais, the vast majority of its genome is of European origin (78.5%), African (14.7%), and Amerindian (6.7%) .


South region:
Finally, in the third and last cohort, made up of 3,736 individuals born in Pelotas, the European genetic influence is (76.1%), with an African contribution (15.9%) and Amerindian contribution (8%)

Ancestralidade brasileira..PNG

Source: https://www.arca.fiocruz.br/bitstream/icict/26745/2/Santos ET Brasil e a ....pdf
 

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Genetic profile of Brazilians on myheritage


The percentages represent the portion of MyHeritage DNA users in Brazil who are of that ethnicity.

View attachment 11945
 

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