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Thread: MC1R - rs1805005 (blonde from the mediterranean)

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    MC1R - rs1805005 (blonde from the mediterranean)

    MC1R alleles associated with lighter pigmentations are much more common in northern than southern Europe, but MC1R - rs1805005 is the exception - being more common in the Mediterranean.

    loiro med.PNGblond med 2.jpg

    Another exception is MC1R - rs11547464 (associated with red hair) that only appears in Iberia or a little in Finland.

    ruivo iberia 1.PNGruivo iberia2.jpg

    Most other alleles are more common in the north - which makes sense since these mutations facilitate melanomas and are probably not useful in the Mediterranean climate.


    KITLG - rs12821256 (blond in northern coutries)

    loiro norte.PNG

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    MC1R - rs1805007 (red hair)

    Attachment 12099

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    A couple of things should make us leery of putting too much stock in any analysis based on MCIR:

    1.The most recent analysis of the effect of MCIR on pigmentation (Mathiesen et al) is that it is a very minor player.

    2. All pigmentation traits are based on a combination of snps. It's dangerous to look at any one snp in isolation.

    3. Obviously there are flaws in this analysis. More of the snp leading to red hair in Iberia than in Great Britain??? It's ludicrous. Either the pathway to red hair includes more or a combination of snps, or this is not a representative sample, probably both. We can't ignore reality in these analyses.


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    Quote Originally Posted by Angela View Post
    A couple of things should make us leery of putting too much stock in any analysis based on MCIR:

    1.The most recent analysis of the effect of MCIR on pigmentation (Mathiesen et al) is that it is a very minor player.

    2. All pigmentation traits are based on a combination of snps. It's dangerous to look at any one snp in isolation.

    3. Obviously there are flaws in this analysis. More of the snp leading to red hair in Iberia than in Great Britain??? It's ludicrous. Either the pathway to red hair includes more or a combination of snps, or this is not a representative sample, probably both. We can't ignore reality in these analyses.
    I agree with you about being a set of factors, but there are studies on the allele related to lighter hair colors especially in southern Europe - maybe it is related to different routes taken by different groups. About the allele for red hair in Iberia - there is also a study relating this gene specifically to Iberia, but the frequency is very low even in Iberia. Generally speaking it is obvious that there are many more redheads on the British Isles.






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    Quote Originally Posted by Angela View Post
    A couple of things should make us leery of putting too much stock in any analysis based on MCIR:

    1.The most recent analysis of the effect of MCIR on pigmentation (Mathiesen et al) is that it is a very minor player.

    2. All pigmentation traits are based on a combination of snps. It's dangerous to look at any one snp in isolation.

    3. Obviously there are flaws in this analysis. More of the snp leading to red hair in Iberia than in Great Britain??? It's ludicrous. Either the pathway to red hair includes more or a combination of snps, or this is not a representative sample, probably both. We can't ignore reality in these analyses.
    The second image I posted in # 2 shows that the other allele - more traditional - for red hair is much more common in GBR. The objective was just to show that some alleles may be more frequent in specific places, although always at low frequencies.

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    Very interesting. Did IE invasion leave any of these alleles in West , Central or South Asia? Light skin probably arose in EEF. We know blue eyes existed in WHG. Did light hair originate in ANE and is there any relation to SE Asians with blondish hair?
    Last edited by ratchet_fan; 20-06-20 at 03:43.

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