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Thread: The genetic structure of Norway

  1. #1
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    3 members found this post helpful.

    The genetic structure of Norway

    Preprint available here: biorxiv.org/content/10.1101/2020.03.20.000299v1.full (can't post hyperlinks due to my low post-count)

    Abstract:
    "The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norwayís long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been the most isolated region in Norway, highlighting the open sea as a barrier to gene flow."

    Not much new, but interesting nevertheless. Some key findings I drew from this:


    • High rates of inbreeding in the far north (Finnmark), Oslofjord-area least inbred
    • Higher rates of Asian ancestry in Finnmark than expected, nearing 25% in the Saami-inhabited Kautokeino
    • The divergent profile of the Southernmost counties (Rogaland, Agder, Telemark) is not due to foreign gene flow or Danish admixture, but rather increased homogeneity and geographical isolation (the sea being a barrier to gene flow) resulting in genetic drift

    I wasn't able to access the supplemental data. It would be interesting to see the figures for Asian/Uralic ancestry by county, although I expect it to predictably follow a north-south cline.

  2. #2
    Regular Member Archetype0ne's Avatar
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    Very interesting Bygdedweller. Thanks for sharing.
    Is there a Haplogroup breakdown?
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  3. #3
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    1 members found this post helpful.
    Quote Originally Posted by Archetype0ne View Post
    Very interesting Bygdedweller. Thanks for sharing.
    Is there a Haplogroup breakdown?
    You're very welcome ArchetypeOne. :)
    No, unfortunately I wasn't able to find anything of the sort. Would be interesting for sure, but I see no mention of haplogroups in the article either. I think this article is only the first in a series of ongoing research-projects on Norwegian DNA, so let's hope they publicize more data in the future.

  4. #4
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    [QUOTE = Bygdedweller; 610027] Pré- impressão disponível aqui: biorxiv.org/content/10.1101/2020.03.20.000299v1.full (não é possível postar hiperlinks devido à minha baixa pós-contagem)

    Resumo:
    "O objetivo do presente estudo foi descrever a estrutura gen√©tica da popula√ß√£o norueguesa usando gen√≥tipos de 6369 indiv√≠duos n√£o aparentados com informa√ß√Ķes detalhadas sobre locais de resid√™ncia. Usando abordagens baseadas em hapl√≥tipos e marcadores √ļnicos padr√£o, relatamos evid√™ncias de duas regi√Ķes com caracter√≠sticas distintas padr√Ķes de varia√ß√£o gen√©tica, um no extremo nordeste e outro no sul da Noruega, conforme indicado pelos √≠ndices de fixa√ß√£o, compartilhamento de hapl√≥tipos, homozigosidade e tamanho efetivo da popula√ß√£o. Detectamos e quantificamos um componente da ancestralidade sami uralica que √© enriquecido no norte Em uma escala mais precisa, descobrimos que as taxas de migra√ß√£o foram afetadas pela topografia, como cristas de montanhas. No contexto mais amplo da Escandin√°via, detectamos elevada rela√ß√£o entre as √°reas de fronteira m√©dia e norte em dire√ß√£o √† Su√©cia.A principal descoberta deste estudo √© que, apesar da longa hist√≥ria mar√≠tima da Noruega e como um antigo territ√≥rio dinamarqu√™s, a regi√£o mais pr√≥xima da Europa continental no sul parece ter sido a regi√£o mais isolada da Noruega, destacando o mar aberto como uma barreira para fluxo g√™nico. "

    N√£o muito novo, mas ainda assim interessante. Algumas descobertas importantes que tirei disso:


    • Altas taxas de endogamia no extremo norte (Finnmark), √°rea de Oslofjord menos endog√Ęmica
    • Taxas mais altas de ascend√™ncia asi√°tica em Finnmark do que o esperado, quase 25% no Kautokeino, habitado por Saami
    • O perfil divergente dos condados mais meridionais (Rogaland, Agder, Telemark) n√£o se deve ao fluxo de genes estrangeiros ou √† mistura dinamarquesa, mas sim ao aumento da homogeneidade e do isolamento geogr√°fico (o mar sendo uma barreira ao fluxo de genes), resultando em deriva gen√©tica

    N√£o consegui acessar os dados suplementares. Seria interessante ver os n√ļmeros da ancestralidade asi√°tica / uralica por condado, embora eu espere que siga previsivelmente um cline norte-sul. [/CITAR]

    interesting

  5. #5
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    My grandparents were from Rogaland but not sure if that really jumps out in my genetic profile

  6. #6
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    Very interesting. Thanks for sharing.

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