firetown
Banned
- Messages
- 866
- Reaction score
- 151
- Points
- 43
View attachment 12861
It is important to differentiate weak D (due to a quantitative difference in the D antigen) from partial D (due to a qualitative difference in the D antigen). Simply put, the weak D phenotype is due to a reduced number of D antigens on a red blood cell. In contrast, the partial D phenotype is due to an alteration in D-epitopes. Thus, in partial D, the number of D antigens is not reduced but the protein structure is altered. These individuals, if alloimmunized to D, can produce an anti-D antibody. Therefore, partial D patients who are donating blood should be labeled as D-positive but, if receiving blood, they should be labeled as D-negative and receive D-negative units.
View attachment 12862
Thus, a Neanderthal mother with partial RhD, Rhc, and Rhe phenotypes and sometimes RH:-18, carrying a Denisovan foetus expressing complete forms of RhD, Rhc and Rhe antigens and expressing the RH18 antigen, would have been prone to be immune to missing epitopes and synthesize anti-RhD, anti-Rhc, anti-Rhe and even anti-RH18 antibodies.
https://www.rhesusnegative.net/staynegative/blood-groups-of-neandertals-and-denisova-decrypted/