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Thread: haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

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    haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

    Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

    Rohrlach, A.B., Papac, L., Childebayeva, A.
    et al. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Sci Rep11, 15005 (2021). https://doi.org/10.1038/s41598-021-94491-z

    https://www.nature.com/articles/s41598-021-94491-z


    Abstract

    Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA studies often fail to utilize the unique perspective that the NRY can yield. Here we introduce a new DNA enrichment assay, coined YMCA (Y-mappable capture assay), that targets the "mappable" regions of the NRY. We show that compared to low-coverage shotgun sequencing and 1240 k capture, YMCA significantly improves the mean coverage and number of sites covered on the NRY, increasing the number of Y-haplogroup informative SNPs, and allowing for the identification of previously undiscovered variants. To illustrate the power of YMCA, we show that the analysis of ancient Y-chromosome lineages can help to resolve Y-chromosomal haplogroups. As a case study, we focus on H2, a haplogroup associated with a critical event in European human history: the Neolithic transition. By disentangling the evolutionary history of this haplogroup, we further elucidate the two separate paths by which early farmers expanded from Anatolia and the Near East to western Europe.







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    These are good news, I hope other teams apply the new method as well and come to similarly useful and impressive results. The result as such is not groundbreaking, but a solid confirmation for the two (ICW and LBK primarily) Neolithic colonisation groups. The new method for yDNA sampling is groundbreaking.

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    Brilliant! Thanks, Pax. :)


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    this paper has already been discussed on another thread in this forum

    it shows the German Michelsberg culture branches of from the Mediterranean farmers

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    this paper reflects what Haak had in his paper many years ago

    that is.......Karsdorf, Derenburg and Halberstadt had the following percentage of ydna Neolitihic samples

    22% = T1a
    22% = H2
    56% = G2a


    this paper states
    With the arrival of Steppe-related ancestry ~ 5 kya, incoming YHGs such as R1a and R1b would largely replace many of the older, “Neolithic” YHGs, such as G2, T1a, and H219,
    Fathers mtdna ...... T2b17
    Grandfather mtdna ... T1a1e
    Sons mtdna ...... K1a4p
    Mothers line ..... R1b-S8172
    Grandmother paternal side ... I1-CTS6397
    Wife paternal line ..... R1a-Z282

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    Quote Originally Posted by torzio View Post
    this paper reflects what Haak had in his paper many years ago

    that is.......Karsdorf, Derenburg and Halberstadt had the following percentage of ydna Neolitihic samples

    22% = T1a
    22% = H2
    56% = G2a


    this paper states
    With the arrival of Steppe-related ancestry ~ 5 kya, incoming YHGs such as R1a and R1b would largely replace many of the older, “Neolithic” YHGs, such as G2, T1a, and H219,
    We already know E1b1b came with Impresso-Cardial Ware colonisation, but the problem is that G2a and H2 being present in both, ICW and LBK, so they can't be distinguished based on that. This is only possible with more refined subclades and this was possible with H2, just by getting better quality, higher resolution samples with the new methods. The same could and should be done with other samples to assert the possible relationships and that's kind of new. Many papers don't treat uniparentals with the respect it deserves, unfortunately. Especially since after the steppe movement, the differences between two groups in Europe were rarely that big to be recognisable unless we deal with a big scale replacement, sometimes not even then.

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    Quote Originally Posted by bicicleur 2 View Post
    this paper has already been discussed on another thread in this forum

    it shows the German Michelsberg culture branches of from the Mediterranean farmers
    Where i think the origin of E-V13 is.

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    Quote Originally Posted by Hawk View Post
    Where i think the origin of E-V13 is.


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    Quote Originally Posted by bicicleur 2 View Post
    this paper has already been discussed on another thread in this forum

    it shows the German Michelsberg culture branches of from the Mediterranean farmers

    Not everyone reads the posts in the various threads. Some papers deserve to have their own thread.

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    Quote Originally Posted by kingjohn View Post
    Somewhere between Baden and Tripolye-Cucuteni, possibly Lengyel-Sopot derived (from where we have 2 E1b1b already in the Middle Danubian zone) is more likely I'd say. E1b1b seems to have been a minority element in many ICW derived groups, and I prefer samples and groups closer in time and space. They might have been related, though.

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    Quote Originally Posted by Pax Augusta View Post
    Not everyone reads the posts in the various threads. Some papers deserve to have their own thread.
    no, it was a thread dedicated to this paper, maybe an earlier publication though

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    Quote Originally Posted by bicicleur 2 View Post
    no, it was a thread dedicated to this paper, maybe an earlier publication though
    here it is :

    https://www.eupedia.com/forum/thread...thic+expansion

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    Fusing threads?

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    Quote Originally Posted by bicicleur 2 View Post
    Ok, it was the preprint, I didn't see that. We merge the threads then, thanks.

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