Neolithic farmers from germany Derenburg LBK

kingjohn

kingjohn

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Abstract
Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA research in the last 10 years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here, we present high quality genome-wide data from the Linear Pottery Culture site Derenburg-Meerenstieg II (DER) (N = 32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the Linear Pottery culture cohort size to ∼100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called Admixture-informed Maximum-likelihood Estimation for Selection Scans that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia
Source:

https://academic.oup.com/mbe/article/39/6/msac108/6586604

P.s
I am with my phone and not a commputer
But when i look in the supplemetal tables:
I have good news for torzio and salento
In our forum
Individual DER031 belong to y haplogroup
T1a1 (y)
others are y haplogroups: G,H,C,I2a2
 
kingjohn said:
Abstract
Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA research in the last 10 years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here, we present high quality genome-wide data from the Linear Pottery Culture site Derenburg-Meerenstieg II (DER) (N = 32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the Linear Pottery culture cohort size to ∼100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called Admixture-informed Maximum-likelihood Estimation for Selection Scans that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia
Source:
https://academic.oup.com/mbe/article/39/6/msac108/6586604
P.s
I am with my phone and not a commputer
But when i look in the supplemetal tables:
I have good news for torzio and salento
In our forum
Individual DER031 belong to y haplogroup
T1a1 (y)
others are y haplogroups: G,H,C,I2a2
Click to expand...

"Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century"

https://reich.hms.harvard.edu/sites...es/inline-files/2022.05.13.491805v1.full_.pdf
 
kingjohn said:
Interesting the T case in erfurt 14th century
Ashkenazi community is t1a1 or t1a2 ?
If it is t1a1 it might be a descendent of the Derenburg Lbk group who absorbed to the jewish community in some point in time:unsure:
Click to expand...

unless he was adopted :) … I also know of y Ts Karsdorf LBKs.
 
kingjohn said:
Abstract
Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA research in the last 10 years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here, we present high quality genome-wide data from the Linear Pottery Culture site Derenburg-Meerenstieg II (DER) (N = 32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the Linear Pottery culture cohort size to ∼100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called Admixture-informed Maximum-likelihood Estimation for Selection Scans that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia
Source:
https://academic.oup.com/mbe/article/39/6/msac108/6586604
P.s
I am with my phone and not a commputer
But when i look in the supplemetal tables:
I have good news for torzio and salento
In our forum
Individual DER031 belong to y haplogroup
T1a1 (y)
others are y haplogroups: G,H,C,I2a2
Click to expand...


I knew of the 3 x T1a1 in Karsdorf

Karsdorf ( 7100yBP - Early Neolithic ) LBK Culture

I0795 ( 7076 ± 90 yBP )
Y-DNA: T1a1a2-Y63197 (xBY154289)
mtDNA: H1 or H1au1b*


I0797 ( 7087 ± 725 yBP )
Y-DNA: T1a1a2-Y63197 (xBY154289)
mtDNA: H46b


Kars537 ( 6958 ± 49 yBP )
Y-DNA: T1a1a2-Y63197 (xBY154289)
mtDNA: J1c6a


Do you have more info on DER031 ?
 
torzio said:
I knew of the 3 x T1a1 in Karsdorf
Karsdorf ( 7100yBP - Early Neolithic ) LBK Culture
I0795 ( 7076 ± 90 yBP )
Y-DNA: T1a1a2-Y63197 (xBY154289)
mtDNA: H1 or H1au1b*
I0797 ( 7087 ± 725 yBP )
Y-DNA: T1a1a2-Y63197 (xBY154289)
mtDNA: H46b
Kars537 ( 6958 ± 49 yBP )
Y-DNA: T1a1a2-Y63197 (xBY154289)
mtDNA: J1c6a
Do you have more info on DER031 ?
Click to expand...

From supplemental table 1:

DER031 -grave 34 - 6141+/-33
-
5211-4993 - snp L162-T1a1- Hv+16311

P.s
This the site in modern germany
https://en.m.wikipedia.org/wiki/Derenburg
I think it is not that far from the karsdorf site
https://en.m.wikipedia.org/wiki/Karsdorf
 
Thanks Kingjohn. Interesting paper, I will definitely give it a look.
 
kingjohn said:
Interesting the T case in erfurt 14th century
Ashkenazi community is t1a1 or t1a2 ?
If it is t1a1 it might be a descendent of the Derenburg Lbk group who absorbed to the jewish community in some point in time:unsure:
Click to expand...


as per the Ashkenazi DNA site ..............they state a zero jews for T1a2-Z19945 branch that Salento and I belong to ...................
 
kingjohn said:
From supplemental table 1:
DER031 -grave 34 - 6141+/-33
-
5211-4993 - snp L162-T1a1- Hv+16311
P.s
This the site in modern germany
https://en.m.wikipedia.org/wiki/Derenburg
I think it is not that far from the karsdorf site
https://en.m.wikipedia.org/wiki/Karsdorf
Click to expand...
It is the Salzland area, the land of the salt.
It became wealthy since the late neolithic due to the salt trade.
It has a complicated history.
Megalithic, globular amphora and corded ware elites were competing for control over that area and their trade routes.

https://upload.wikimedia.org/wikipedia/commons/thumb/0/0b/Elbe_basin.png/1024px-Elbe_basin.png

1024px-Elbe_basin.png
 
y haplogroups and mtdna in the site from 32 remains

DER002-grave 42- y haplogroup G2a2b2b2- mtdna w5 ( second degree related DER013)
DER003- grave 39- mtdna t2b ( second degree related to DER006)
DER004-grave 17- y haplogroup H2- mtdna k1a
DER005-grave 21-6147+/-32 5209-5001 -mtdna N1a1a1a
DER006- grave 40-y haplogroup G2a2b2b2- mtdna j1c (second degree related to DER003)
DER007- grave 33-mtdna N1a1a1
DER009-grave 29- 6125+/-235209-4957- y haplogroup H2 - mtdna HV+16311
DER010-grave30- 6093+/-22 5205-4937-mtdna N1a1a1a3
DER011-grave10-y haplogroup H2- mtdna H1j( son DER022)
DER012-grave43- mtdna T2b23( second degree related DER014 and DER015)
DER013-grave18- y haplogroup G2a2b2b2- mtdna W5 ( second degree related DER002)
DER014-grave19- 6015+/-35 5000-4797- y haplogroup H2- mtdna v1a( brother DER015,second degree related DER012)
DER015-grave 20- mtdna V1A( sister DER014, second degree related DER012)
DER017-grave 15- y haplogroup C1a2b-mtdna H2a2
DER018-grave 22- mtdna X2b( daughter DER019)
DER019-grave 22-mtdna X2B(mother DER018)
DER020-grave 12- 6101+/-34 5209-4905 -y haplogroup H2 -mtdna H1o
DER021-grave 26-y haplogroup I2a2b- mtdna HV+16311
DER022-grave 32- 6151+/-27 5209-5007- mtdna H1j( mother DER011)
DER023-grave 37-mtdna J1c
DER024-grave 38- 6142+/-34 5211-4993 -mtdna T2e
DER026-grave 46-y haplogrup H2- mtdna K1a3a3
DER028-mtdnaT2b
DER029-grave 9 -mtdna H88
DER030-grave 35- y haplogroup H2- mtdna R12'21
DER031-grave 34-6141+/-33 5211-4993-y haplogroup T1a1- mtnda HV+16311
DER032-grave 31-6257+/-40 5316-5066-y haplogroup H2- mtdna HV+16311
DER033-grave 48-mtdna J1c
DER034-grave 44-mtdna K2a
DER035-grave 47-mtdna U5a
DER036-grave 47-mtdna T2+16189
DER037-grave49-6148+/-33 5210-5000-mtdna T2b

p.s
it look like some of them were relatives of eachother
 
"We primarily found G2a2 and H2 Y haplogroups associated with Neolithic farmers (Lacan et al. 2011; Haak et al. 2015; Rivollat et al. 2020; Rohrlach et al. 2021). We also observed one male with the Y-chromosome I haplotype that is generally common among European HGs and therefore considered as a signal of male HG ancestry contribution but also reported in lower frequency from Iberian and French Neolithic individuals (Lipson et al. 2017; Rivollat et al. 2020)."

"In general, we found consistently low levels of inbreeding across all early Neolithic groups in Central Europe, suggesting that EEFs lived in larger groups or groups with an extended mating network, and ultimately stemmed from a source deme with a large effective population size (Ringbauer et al. 2020)."

"Together with the results from our analysis of the lack of inbreeding and inter-site biological relatedness, this further suggests that the early Neolithic LBK farmers were part of a larger population, did not practice close biologically related mating, and prevented inbreeding. In comparison, based on limited biological relatedness among individuals in intramural burials, it has been suggested that Neolithic Anatolia was not a strictly kin-based society (Pilloud and Larsen 2011; Yaka et al. 2021)."

" On one hand, vitamin D is synthesized upon UVR exposure (Jablonski and Chaplin 2010), and, on the other hand, folate has to be protected from photolysis from UVR (He et al. 2009). Our findings support the idea of coevolution of folate synthesis and lighter pigmentation in the EF, compared to the HGs and the African outgroup populations. Moreover, our study narrows down the timing of selection on SLC24A5 to after the split between the European HGs and the ancestors of the early Neolithic farmers. Of note, European HGs are characterized by a darker skin color, even though they occupied higher latitudes with low UVR exposure. The current hypothesis is that the diet based on meat/fish served as a sufficient source of vitamin D in higher latitudes for the HGs, similar with what has been shown in the Inuit and other Arctic indigenous populations (Kolahdooz et al. 2013; Schaebel et al. 2015).We analyzed SNPs that are associated with pigmentation in the ancient populations separately (LBK, Anatolia_N, WHG) (table 1), since we hypothesized that migration to a higher latitude from Anatolia to central Europe could be associated with positive selection for light skin color phenotype. Based on the comparison between LBK and Anatolia_N, we did not see a major shift in skin color SNPs that are involved in determining lighter skin pigmentation, suggesting that this adaptation already happened in Anatolia/the Near East during the transition to a sedentary farming lifestyle."
It looks to me as if selection for blue eyes was also taking place in Anatolia.

Why didn't they give the percentages for the remaining 2/3?
 
With only 24.7kb of DNA on ENA there is no way to explore the traits of the individuals or proof the statements of the paper.
 
kingjohn said:
y haplogroups and mtdna in the site from 32 remains
DER002-grave 42- y haplogroup G2a2b2b2- mtdna w5 ( second degree related DER013)
DER003- grave 39- mtdna t2b ( second degree related to DER006)
DER004-grave 17- y haplogroup H2- mtdna k1a
DER005-grave 21-6147+/-32 5209-5001 -mtdna N1a1a1a
DER006- grave 40-y haplogroup G2a2b2b2- mtdna j1c (second degree related to DER003)
DER007- grave 33-mtdna N1a1a1
DER009-grave 29- 6125+/-235209-4957- y haplogroup H2 - mtdna HV+16311
DER010-grave30- 6093+/-22 5205-4937-mtdna N1a1a1a3
DER011-grave10-y haplogroup H2- mtdna H1j( son DER022)
DER012-grave43- mtdna T2b23( second degree related DER014 and DER015)
DER013-grave18- y haplogroup G2a2b2b2- mtdna W5 ( second degree related DER002)
DER014-grave19- 6015+/-35 5000-4797- y haplogroup H2- mtdna v1a( brother DER015,second degree related DER012)
DER015-grave 20- mtdna V1A( sister DER014, second degree related DER012)
DER017-grave 15- y haplogroup C1a2b-mtdna H2a2
DER018-grave 22- mtdna X2b( daughter DER019)
DER019-grave 22-mtdna X2B(mother DER018)
DER020-grave 12- 6101+/-34 5209-4905 -y haplogroup H2 -mtdna H1o
DER021-grave 26-y haplogroup I2a2b- mtdna HV+16311
DER022-grave 32- 6151+/-27 5209-5007- mtdna H1j( mother DER011)
DER023-grave 37-mtdna J1c
DER024-grave 38- 6142+/-34 5211-4993 -mtdna T2e
DER026-grave 46-y haplogrup H2- mtdna K1a3a3
DER028-mtdnaT2b
DER029-grave 9 -mtdna H88
DER030-grave 35- y haplogroup H2- mtdna R12'21
DER031-grave 34-6141+/-33 5211-4993-y haplogroup T1a1- mtnda HV+16311
DER032-grave 31-6257+/-40 5316-5066-y haplogroup H2- mtdna HV+16311
DER033-grave 48-mtdna J1c
DER034-grave 44-mtdna K2a
DER035-grave 47-mtdna U5a
DER036-grave 47-mtdna T2+16189
DER037-grave49-6148+/-33 5210-5000-mtdna T2b
p.s
it look like some of them were relatives of eachother
Click to expand...
Years ago..I read that these people where chasing the Red Deer ( living in these areas ) for meat ..............they banded in groups of about 10...usually 7 men and 3 women ............a women in the group would over time have a child from a different man in the group.....scenario is not hard to accept
 
Last edited:
torzio said:
Yes ago..I read that these people where chasing the Red Deer ( living in these areas ) for meat ..............they banded in groups of about 10...usually 7 men and 3 women ............a women in the group would over time have a child from a different man in the group.....scenario is not hard to accept
Click to expand...



here are the bam files of this paper :

https://www.ebi.ac.uk/ena/browser/view/PRJEB52488?show=reads

maybe you can try to upload DER031 to yfull
he will probably end with the same branch as the krasdorf individual

https://www.yfull.com/tree/T-Y63197/
 
torzio said:
So,......DER031 is with the ancient T in YFull of Kars537 ( which I presented to you in an earlier post #5)
Click to expand...
We can't be sure
But since you are a member in anthrogenica
You can ask one of experts there( pribislav, david busch, rafc ,adamm)to have a look at his bam file in the link in my previews post

P.s
it is very likely DER031 will be in krasdorf branch
In yfull
But they need to check him to confirm that :unsure:
 
Last edited:
kingjohn said:
here are the bam files of this paper :

https://www.ebi.ac.uk/ena/browser/view/PRJEB52488?show=reads

maybe you can try to upload DER031 to yfull
he will probably end with the same branch as the krasdorf individual

https://www.yfull.com/tree/T-Y63197/
Click to expand...


... as of now he can't, the downloaded .bam / .fastq files are empty, ... the Dod. k12 coordinates were produced from their alternative data files.

https://www.eupedia.com/forum/threads/41751-aDNA-(Dodecad-K12b)?p=649178&viewfull=1#post649178

... other data files: https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.HOKI5I
 
torzio said:
Years ago..I read that these people where chasing the Red Deer ( living in these areas ) for meat ..............they banded in groups of about 10...usually 7 men and 3 women ............a women in the group would over time have a child from a different man in the group.....scenario is not hard to accept
Click to expand...

Uneasy to check. And 3 woman for 7 guy is very low to maintain cohesion in a group, IMO. And how can we verify this sharing of women was so well accepted then? Except maybe if this sharing was the only mean to maintain cohesion in survival conditions and in a small group? I stay puzzled here.
 
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