Insitome Results! (Neanderthal)

Jovialis · Jul 24, 2017

https://www.eupedia.com/forum/threa...-(Neanderthal)?p=565280&viewfull=1#post565280

Since I'm already a Helix customer, I procured Insitome (Neanderthal chapter) for $29.99. Moreover, my results were ready in 5 minutes, since my DNA is already sequenced. They will be rolling out with other chapters that will be avaliable for purchase in the future.

Below are screen caps from my results. According to Insitome, I am 1.2% Neanderthal (National Geographic-Helix had me at 1.4% )

Moreover, they tell you what Neanderthal traits you have inherited, and which are human. They also tell you what specific gene you have acquired from admixture.

I literally have the mind of a Neanderthal!

Jovialis · Jul 25, 2017

davef · Jul 25, 2017

What's fascinating is that you have a high IQ, yet some of your Neanderthal genes are genes that determine intellectual ability! Something tells me that there may have been gifted Neanderthals (gifted on a human scale) and that they may have been more sophisticated than expected.

Jovialis · Jul 26, 2017

WARS2
https://www.ncbi.nlm.nih.gov/gene/10352

TBX15
https://www.ncbi.nlm.nih.gov/gene/6913

Found something interesting regarding these two genes. They were inherited by admixture with Denosivian. Apparently, this gene was developed to withstand cold areas in the Arctic. Today, nearly 100% of Greenland Inuit have WARS2, and it is found in lower frequency with Modern Europeans, and Asians.

Perhaps it comes from western Neanderthals intermixing with eastern Neanderthals (Denosivian), prior to intermixing with Modern Homo sapiens.

Or perhaps it has something to do with my eastern and/or northeastern European autosomal admixture.

Furthermore, I learned this from the "Genius match" from NG. The paternal-lineage that went on to become haplogroup R1a/R1b took a turn into Asia, prior to Europe, back when it was M207. They probably picked up some admixture with the Eastern Neanderthal (Denosvian). I would like to hear from someone with more knowledge about this lineage, in regards to my hypothesis.

65,000-45,000 years ago

Humans have just ventured out of Africa on their way to conquer the world. Yet these pioneers are still limited to South and Southwest Asia, where they are encountering new animals and plants, like nothing they had known from ancestral Africa.

During this time, I shared a common ancestor with:

Thomas Jefferson (Paternal Match)

Nikola Tesla (Paternal Match)

Petrarch (Maternal Match)

Abraham Lincoln (Maternal Match)

Genghis Khan (Paternal Match)

Leo Tolstoy (Paternal Match

Above is a screencap from the insitome description of my fat storage.

Jovialis · Jul 26, 2017

davef said:
What's fascinating is that you have a high IQ, yet some of your Neanderthal genes are genes that determine intellectual ability! Something tells me that there may have been gifted Neanderthals (gifted on a human scale) and that they may have been more sophisticated than expected.

I haven't delved into the 14 Neanderthal genes associated with intelligence yet. But apparently, TANC1 has a lot to do with visual learning.

I usually found myself to be very bored in school as a child. My teachers often complained that I wouldn't "sit still", in class. Nevertheless, I always liked learning, on my own terms. I guess I found grammar school to be very under-stimulating. I had very old teachers, and this was back in the early 90s too. I'm sure a lot has changed.

EDIT:

Just saw this article regarding Neanderthal genes and their effect on the brain and cranium.

https://www.nature.com/articles/s41598-017-06587-0

EDIT2:

I made a thread about it.

LeBrok · Jul 26, 2017

davef said:
What's fascinating is that you have a high IQ, yet some of your Neanderthal genes are genes that determine intellectual ability! Something tells me that there may have been gifted Neanderthals (gifted on a human scale) and that they may have been more sophisticated than expected.

I would guess that there are thousands genes regulating brain functions, architecture, neuronal connection and speed, etc. One allele, Neanderthal or not, won't change much in most cases.

Johane Derite · Jul 26, 2017

LeBrok said:
One allele, Neanderthal or not, won't change much in most cases.

I don't know how well this works as a general rule. You only need to inherit one copy of the faulty allele to have Huntington's disorder

LeBrok · Jul 26, 2017

Johane Derite said:
I don't know how well this works as a general rule. You only need to inherit one copy of the faulty allele to have Huntington's disorder

In this case we are talking about working allele from a very close cousin, and it worked fine in humans for thousands of years. The point was not to expect a dramatic improvement in brain function. Possible but unlikely.

Angela · Jul 26, 2017

For a critical view on this study about Neanderthal brain structure:

"Small sample size, w. seemingly relatively little discussion of pop structure. Not sure I'd bet on it."
https://twitter.com/Graham_Coop

Jovialis · Jul 26, 2017

Angela said:
For a critical view on this study about Neanderthal brain structure:

"Small sample size, w. seemingly relatively little discussion of pop structure. Not sure I'd bet on it."
https://twitter.com/Graham_Coop

Ah, that's unfortunate.

I hope scientists produce a more rigorous study on this subject in the future.

Jovialis · Aug 1, 2017

After reading further in-dept into the test results, I find the descriptions for the genes to be dubious.

For example, it says I have Human muscle growth and development. Yet the description says the gene DMD is a result of Neanderthal admixture. Does this mean, I don't have the DMD gene? Or even though it's a Human version, it was spawned out of admixture between Neanderthals and Humans?

The same goes for all of the descriptions that say "Human version". They say they're a result of admixture with Homo Sapiens and Neanderthals or Denosivans.

EDIT: I just messaged Insitome about this question.

davef · Aug 1, 2017

Yeah, i guess what makes it a human version is the fact that it's at least partially human since its a result of mixing between humans and Neanderthals/Denisovians...but is there/was there a purely human version?

Looking forward to the answer to your question.

Jovialis · Aug 8, 2017

davef said:
Yeah, i guess what makes it a human version is the fact that it's at least partially human since its a result of mixing between humans and Neanderthals/Denisovians...but is there/was there a purely human version?

Looking forward to the answer to your question.

Here's the reply from Insitome.

if a trait lists you as the "human" version, it means you did not have the Neanderthal version of the trait (in science terms called a haplotype), and it was not the product of admixture. Whether Human or Neanderthal version, it is still the same DMD gene, and there are small differences in the DNA that allow us to identify ancestries. Genes listed in the bottom of the descriptions indicate which genes were tested. Thanks, and sorry for the delay in this reply.

Salento · Aug 8, 2017

My Results:
1.2% (1.4% on Geno 2 Helix)
HAIR
- Pigmentation: Human
SKIN
- Sun Damage Repair: Human
SPINE
- Torso Shape: Human
COGNITION
- Learning: Neanderthal
ENVIRONMENTAL REACTION
- Fat Storage: Neanderthal
- High altitude adaptation: Human
IMMUNITY
- Interpreting Immune Signal: Human
- Pathogens Recognition: Neanderthal
- Viral Immune Response: Neanderthal
MUSCLE
- Muscle Growth and Development: Human

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Jovialis · Aug 8, 2017

Salento said:
My Results:
1.2% (1.4% on Geno 2 Helix)
HAIR
- Pigmentation: Human
SKIN
- Sun Damage Repair: Human
SPINE
- Torso Shape: Human
COGNITION
- Learning: Neanderthal
ENVIRONMENTAL REACTION
- Fat Storage: Neanderthal
- High altitude adaptation: Human
IMMUNITY
- Interpreting Immune Signal: Human
- Pathogens Recognition: Neanderthal
- Viral Immune Response: Neanderthal
MUSCLE
- Muscle Growth and Development: Human

Sent from my iPhone using Eupedia Forum

Cool results! Once again, we are very similar. Interesting how NG had us both at 1.4%, and Insitome has us both at 1.2%

I guess, we can say its within the 1.3% range. Nevertheless, Insitome is prioritized for neanderthal admixture, so I would be more inclined to believe them a bit more.

Salento · Aug 8, 2017

Spencer Wells of the Genographic Project is involved with Insitome.
Hopefully all tests are performed with High Standard.

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Jovialis · Aug 8, 2017

Salento said:
Spencer Wells of the Genographic Project is involved with Insitome.
Hopefully all tests are performed with High Standard.

Sent from my iPhone using Eupedia Forum

1.3% is the average amount for the helix NG test. I wonder what Insitome considers to be the average Neanderthal DNA. Maybe I should message them for the answer.

Edit:

I sent them an e-mail regarding the questions about their methods of scaling, and what they use as their averages, for Neanderthal Admixture, vs the National Geographic test.

Jovialis · Aug 9, 2017

This was their response:

The method we use to estimate of your Neanderthal and Denisovan percentages depends on particular population genetic assumptions. The qualitative presence (>0%) or absence (0.0%) of Neanderthal ancestry is assured by all calculation methods, but your quantitative result varies based on these assumptions. The models we use to calculate your percentage are informed by the latest science, and this means the percentage may change slightly as new scientific discoveries are made. Insitome uses the latest science, so you can rest assured that our estimates are the most up-to-date available. - Science team

Jovialis · Aug 14, 2017

Metabolism reveals the (r)evolutionary story behind your diet—how your genome has been tailored over millennia to the foods your ancestors ate, and what it means for you today. Changes in the human diet have resulted in changes in our own DNA. In the process of adopting new diets, we’ve adapted to them as well. Discover the next chapter in the story of you, Metabolism, to find out the truth behind why you are what you eat.

https://www.helix.com/shop/ancestry

You are what you eat. This Insight reveals the (r)evolutionary story behind your diet - how your genome has been tailored over the millennia to the foods your ancestors ate, and what it means for you today.

http://insito.me/app/product/traits

Looking into the genetics behind the body's metabolism is the next app Insitome is going to release eventually. It's suppose to assess how food our ancestors ate, contributed to how our bodies' work. I hope this will give some insight into ancient human origins from the paleolithic to the iron age.

LeBrok · Aug 14, 2017

I like that, and can't wait for such app.

Insitome Results! (Neanderthal)

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