Admixtools Academic qpAdm Model Replication

[Jovialis]

With a big thanks to Maciamo for creating it, we are proud to announce the creation of the Admixtools sub-forum!

This thread will be dedicated to the re-creation of qpadm models from academic papers.
The object of the thread is to post FAM or Ind files that are modified to replicate a select study of your choice. As well discovery of novel insights based on those replications.

Since I already did one myself, here is the FAM for a replication of Raveane et al. 2022:

v54.1.p1_HO_Raveane_2022

MediaFire is a simple to use free service that lets you put all your photos, documents, music, and video in a single place so you can access them anywhere and share them everywhere.

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[Jovialis]

Sarno et al. 2021 right and left group:


Prompt

# Define paths for dataset
prefix = "D:\\Bioinformatics\\01_Admixtools_Dataset\\v54.1.p1_HO_Jovialis_Plink\\v54.1.p1_HO_Jovialis"
my_f2_dir = "D:\\Bioinformatics\\my_f2_dir_Jovialis"


# Load necessary libraries
library(admixtools)
library(tidyverse)


# Define populations
target = c('Italian_South.HO')  # Update this if your sample has a different name in the merged dataset
left = c('Steppe_EMBA', 'Anatolia_N', 'WHG', 'CHG_Iran_N')


# Right list
right = c('Ust_Ishim', 'Kostenki14', 'MA1_HG', 'Goyet', 'ElMiron', 'Vestonice16', 'Villabruna', 'EHG', 'Levant_N', 'Natufian', 'Mota')


# Generate f2 stats
mypops = c(right, target, left)
extract_f2(prefix, my_f2_dir, pops = mypops, overwrite = TRUE, maxmiss = 1)
f2_blocks = f2_from_precomp(my_f2_dir, pops = mypops, afprod = TRUE)


# Run the model
results = qpadm(prefix, left, right, target, allsnps = TRUE)
results$weights
results$popdrop

v54.1.p1_HO_Sarno_2021

MediaFire is a simple to use free service that lets you put all your photos, documents, music, and video in a single place so you can access them anywhere and share them everywhere.

www.mediafire.com

 

[Jovialis]

Skourtonioti et al. 2023 R11 set for Right group:

# ---- Skourtanioti et al. 2023 qpAdm Reference model ----

# Set the correct dataset path
prefix <- "D:\\Bioinformatics\\01_Admixtools_Dataset\\v54.1.p1_HO_Jovialis_Plink\\Skourtanioti_2023\\v54.1.p1_HO_Jovialis"
my_f2_dir <- "D:\\Bioinformatics\\my_f2_dir_Jovialis"

# Load necessary libraries
library(admixtools)
library(tidyverse)

# Define populations
target <- c('Jovialis')
left <- c('Greece_Minoan_Lassithi', 'Germany_CordedWare')
right <- c('Ethiopia_4500BP.SG', 'Russia_Ust_Ishim_HG.DG', 'Russia_Kostenki14.SG', 'Serbia_IronGates_Mesolithic', 'WHG', 'CHG', 'EEHG', 'W_Anatolia_N', 'Iran_GanjDareh_N', 'Israel_Natufian', 'ANE')

# Generate f2 Stats
mypops <- c(right, target, left)
extract_f2(prefix, my_f2_dir, pops = mypops, overwrite = TRUE, maxmiss = 1)
f2_blocks <- f2_from_precomp(my_f2_dir, pops = mypops, afprod = TRUE)

# Run the Model
results <- qpadm(prefix, left, right, target, allsnps = TRUE)
results$weights
results$popdrop

v54.1.p1_HO_Jovialis

MediaFire is a simple to use free service that lets you put all your photos, documents, music, and video in a single place so you can access them anywhere and share them everywhere.

www.mediafire.com