Angela
Elite member
- Messages
- 21,823
- Reaction score
- 12,329
- Points
- 113
- Ethnic group
- Italian
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia
http://www.cell.com/ajhg/abstract/S0002-9297(16)00003-3
ADH1B is associated with decreased risk of alcoholism. It was previously discovered in East Asians, so this would be a case of convergent evolution.
A "T" at rs1229984 is protective. I knew I had it, and I'm sure I got it from my mother, who probably was homozygous for it, unlike me. My father's family like their drink, even if they control it.
The other two sites which seem to be under selection are IGFBP3, which seems to be related to tumor suppression, and IGH, which has to do with immune response.
https://en.wikipedia.org/wiki/IGFBP3
https://en.wikipedia.org/wiki/IGH@
I'll see if I can find the full text somewhere.
http://www.cell.com/ajhg/abstract/S0002-9297(16)00003-3
ADH1B is associated with decreased risk of alcoholism. It was previously discovered in East Asians, so this would be a case of convergent evolution.
A "T" at rs1229984 is protective. I knew I had it, and I'm sure I got it from my mother, who probably was homozygous for it, unlike me. My father's family like their drink, even if they control it.
The other two sites which seem to be under selection are IGFBP3, which seems to be related to tumor suppression, and IGH, which has to do with immune response.
https://en.wikipedia.org/wiki/IGFBP3
https://en.wikipedia.org/wiki/IGH@
I'll see if I can find the full text somewhere.
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