When it comes to humans, according to prof. Luiza Handschuh:
"(...) The genomes of humans, animals, plants, and bacteria differ in length and nucleotide sequence, but the more closely related the species, the more of similar fragments they have. The human genome is large and contains over 3 billion nucleotides. If we compare the genomes of individual people who are not close relatives, we will find that they are identical on average in 99.85%. However, the seemingly small percentage of differences (0.15%) related to the occurrence of various types of mutations or variable (polymorphic) sites, amounts to as much as 4.5 million nucleotides. Many of these differences do not translate in any way into the physical characteristics of the organism, but they are valuable from the point of view of genetics and population genomics, forensic medicine, and genetic genealogy. (...)"