HLA-DR10 : distribution map, subtypes, SNPs and associated medical conditions

Maciamo

Veteran member
Admin
Messages
10,115
Reaction score
3,561
Points
113
Location
Lothier
Ethnic group
Italo-celto-germanic
Here is a map showing the allele frequency of HLA-DR10. The maximum frequencies are observed in the Lebanon (5.2%), Saudi Arabia (4.8%), Palestine (4.7%), Jordan (3.8%), Morocco (3.3%), Algeria (3%), Tunisia (3%), and oddly enough also among the Saami people (2.9%). It is absent from the Basque population and nearly absent from Sardinia and Brittany. You can visualise the data by country on this table of HLA-DR frequencies.

Worldwide, the highest frequencies are observed in Africa (9% in Sudan and Burkina Faso, 6% in Mozambique) and in South Asia (typically above 5%) and especially in South India (10 to 21%). In Europe, the Gypsies also have higher frequencies (about 4%).




The distribution suggests a strong Southwest Asian and North African association. However its absence from Sardinia and the Basque country cannot link it to the Neolithic diffusion. Actually the closest association with Y-DNA haplogroups appears to be with E-M34 and J1-P58. Apart from being the two main Semitic paternal lineages, they are also found among the Greeks and Italians are reasonably high frequencies, which means that they (and HLA-DR10) would have spread around the Roman Empire, which pretty much matches the higher frequencies on the map.

Volga-Uralic people also carry DR10 and frequencies around 1.5%, with a peak of 3% among northern Swedish Saami. So DR10 seem to have two distinct origins: a Southwest Asian one and a Siberian one.


Medical associations

DRB1*1001 is associated with ovarian cancer and invasive squamous cell cervical cancer.

The DRB1*1001 : DQA1*01 : DQB1*05 haplotype is linked with rheumatoid arthritis.


SNP's

You can verify if you carry HLA-DR10 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. There are a dozen known subclades, but only DRB1*10:01 is common.

- DRB1*10:01 : rs4148871 (A), rs2071538 (A)

You normally need to be positive for both alleles.
 
Last edited:
Here is a map showing the allele frequency of HLA-DR10. The maximum frequencies are observed in the Lebanon (5.2%), Saudi Arabia (4.8%), Palestine (4.7%), Jordan (3.8%), Morocco (3.3%), Algeria (3%), Tunisia (3%), and oddly enough also among the Saami people (2.9%). It is absent from the Basque population and nearly absent from Sardinia and Brittany. You can visualise the data by country on this table of HLA-DR frequencies.

Worldwide, the highest frequencies are observed in Africa (9% in Sudan and Burkina Faso, 6% in Mozambique) and in South Asia (typically above 5%) and especially in South India (10 to 21%). In Europe, the Gypsies also have higher frequencies (about 4%).




The distribution suggests a strong Southwest Asian and North African association. However its absence from Sardinia and the Basque country cannot link it to the Neolithic diffusion. Actually the closest association with Y-DNA haplogroups appears to be with E-M34 and J1-P58. Apart from being the two main Semitic paternal lineages, they are also found among the Greeks and Italians are reasonably high frequencies, which means that they (and HLA-DR10) would have spread around the Roman Empire, which pretty much matches the higher frequencies on the map.

Volga-Uralic people also carry DR10 and frequencies around 1.5%, with a peak of 3% among northern Swedish Saami. So DR10 seem to have two distinct origins: a Southwest Asian one and a Siberian one.


Medical associations

DRB1*1001 is associated with ovarian cancer and invasive squamous cell cervical cancer.

The DRB1*1001 : DQA1*01 : DQB1*05 haplotype is linked with rheumatoid arthritis.


SNP's

You can verify if you carry HLA-DR10 by checking your raw data from 23andMe, Geno 2.0 or FamilyFinder. There are a dozen known subclades, but only DRB1*10:01 is common.

- DRB1*10:01 : rs4148871 (A), rs2071538 (A)

You normally need to be positive for both alleles.



as for my family

all negatives for both except son is AA for rs2071538
 
Is there going to be a map of HLA-DR14 distribution?
 

This thread has been viewed 8663 times.

Back
Top