Angela
Veteran member
- Messages
- 21,783
- Reaction score
- 12,343
- Points
- 113
- Ethnic group
- Italian
See:
Maria Avila Arcos et al
https://www.biorxiv.org/content/10.1101/534818v1
"[FONT="]Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico′s indigenous population is highly differentiated and substructured, thus potentially harboring higher proportions of private genetic variants of functional and biomedical relevance. Here we have targeted the coding fraction of the genome and characterized its full site frequency spectrum by sequencing 76 exomes from five indigenous populations across Mexico. Using diffusion approximations, we modeled the demographic history of indigenous populations from Mexico with northern and southern ethnic groups splitting 7.2 kya and subsequently diverging locally 6.5 kya and 5.7 kya, respectively. Selection scans for positive selection revealed [/FONT]BCL2L13[FONT="] and [/FONT]KBTBD8[FONT="] genes as potential candidates for adaptive evolution in Rarámuris and Triquis, respectively. [/FONT]BCL2L13[FONT="] is highly expressed in skeletal muscle and could be related to physical endurance, a well-known phenotype of the northern Mexico Rarámuri. The [/FONT]KBTBD8[FONT="] gene has been associated with idiopathic short stature and we found it to be highly differentiated in Triqui, a southern indigenous group from Oaxaca whose height is extremely low compared to other native populations."
Once again, selection is relatively swift in human history.[/FONT]
Maria Avila Arcos et al
https://www.biorxiv.org/content/10.1101/534818v1
"[FONT="]Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico′s indigenous population is highly differentiated and substructured, thus potentially harboring higher proportions of private genetic variants of functional and biomedical relevance. Here we have targeted the coding fraction of the genome and characterized its full site frequency spectrum by sequencing 76 exomes from five indigenous populations across Mexico. Using diffusion approximations, we modeled the demographic history of indigenous populations from Mexico with northern and southern ethnic groups splitting 7.2 kya and subsequently diverging locally 6.5 kya and 5.7 kya, respectively. Selection scans for positive selection revealed [/FONT]BCL2L13[FONT="] and [/FONT]KBTBD8[FONT="] genes as potential candidates for adaptive evolution in Rarámuris and Triquis, respectively. [/FONT]BCL2L13[FONT="] is highly expressed in skeletal muscle and could be related to physical endurance, a well-known phenotype of the northern Mexico Rarámuri. The [/FONT]KBTBD8[FONT="] gene has been associated with idiopathic short stature and we found it to be highly differentiated in Triqui, a southern indigenous group from Oaxaca whose height is extremely low compared to other native populations."
Once again, selection is relatively swift in human history.[/FONT]