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The mystery of Lactase Persistence (LP) in Europeans

hunter gatherers did not grow cows or sheep so Lactose Persistence deffinitely happened in Europe with the Neolithic Farmers. It was probably one of those genes that got in Europe from the Levant, together with white skin. Everywhere you go in Europe most y-dna is Neolithic or later, so all these new males brought their LP genes with them. The first farming communities were in Anatolia and Levant, next were the Balkans; and R1b, E1b1b, and J, went through the Balkans first.

Yes, it correlates somewhat with the availability of milk cattle. Also south asia uses lots of dairy where cows are very important.
 
@kamani

The allele could have come from anywhere. The interesting part is why it spread to fixation along the Atlantic Coast and northwest Europe.
If that's true, it would be because Farming and sedentary lifestyle brought a population boom in those areas more so than in others, due to the vast lowlands and farming lands available (which increased even more with metal axes and deforestation). Just look at the post-Neolithic mutations explosion of R1b in NW Europe in a short period of time. The hunter-gatherers did not dissapear, they were just grossly outnumbered by the farmers. This is sort of like the Natives story in North-America, the main reason Indians lost their land is because they were slowly outnumbered by a more modern population. It was not uncommon for European women to bear 8 or 9 children in the "New World", back in the day. A lot of them married more than once, since a lot of men died early due to harshness of life. As you move more East in Eurasia, the story becomes more like South-America, where the colonizers mixed with the Natives as much as with each-other. For some reason, people in the Russian steppes resisted sedentary lifestyle until the middle ages almost. When the Huns got into Europe, they were nomadic semi hunter-gatherer/plunderer with some livestock that they dragged along.
As a curiosity: cattle theft by Natives became such an annoyance in the American West, that it was lawfully punishable by hanging.
 
As a curiosity: cattle theft by Natives became such an annoyance in the American West, that it was lawfully punishable by hanging.
I guess when buffalo was exterminated cows became "buffalo substitute" for natives. But it wasn't for milk, it was for meat.
 
It wasn't for meat it was for profit. The Comanche were raiding Northern Mexico and selling it to Texan cattle ranchers. It also helped demoralize the Mexicans and helped the US in the American Mexican war. Rustling was a problem all over the west, but it was mainly a profiteering expedition.
 
I don't know if this was brought up, but I wonder how the domestication of the horse, and the use of mare milk contributed to lactose tolerance? I know that mare milk has twice the lactose, than cow or goats milk. If R1b and R1a were Steppe people, than maybe they developed it to survive off of horse meat and mare milk, where agriculture was not possible or very unreliable. Early attempts of agriculture was tough in northern climates, and often failed. So, maybe these horse riders who adapted to drinking mare milk (or partly fermented) brought their LT to Europe where they engaged in cattle pastoralism in the north and were already suited for cows milk.
 
I had ice cream with my lunch and really enjoyed it, even though it's quite cold and wintery here. I feel better when I have more dairy in my diet. And although my Y haplotype is I1, I can't help but wonder how many of my indirect paternal ancestors were R1b.
 
@kamani

The allele could have come from anywhere. The interesting part is why it spread to fixation along the Atlantic Coast and northwest Europe.


@Angela

"Good post about why lactase persistence might have been particularly important in the early Neolithic and Bronze Age in Northwestern Europe."

Ty. I think it's the critical thing people are missing. The important bit about LT is not that population x had milk (as that was true of lots of populations); the important bit must be (imo) that population x had milk *and didn't have* a lot of other alternatives.

"
The reason that I went to the trouble of doing the research is that the Finnish paper seemed to indicate that actual milk drinking was not as common in the distant past as it subsequently became, and so the high levels were probably the result of the migration of a population that already carried the mutation and consumed milk. If anyone read the paper on The History of Milk for which I provided a link, for example, Germans drank virtually no liquid milk in 1860"

I don't think that follows though. Milk drinking *declined* with urbanization because fewer people lived on farms and milk had to be fresh. Milk drinking increased again with railways.

I think the main source of dietary milk in the Atlantean neolithic was bowls of milk mixed with nuts, berries, grains, acorns etc like muesli or porridge.

http://en.wikipedia.org/wiki/Porridge

"Oat porridge, traditional and common in Scotland, English-speaking countries, Nordic countries, and Germany.[citation needed]Oat porridge has been found in the stomachs of 5,000 year old Neolithicbog bodies in Central Europe and Scandinavia."

Bowls of milk mixed with whatever you could grow or forage sounds like a very plausible staple diet for northwest Europe at this time before the neolithic package was adapted for the local climate so I think it was fixed (in those regions) long ago.

Alternatively the first population who developed LT somewhere along the Atlantic coast might haven been able to spread everywhere along that coastline where that ecological niche existed. That may have been what you meant by migration?

This is pure speculation, of course, but I doubt the LP gene came with the Neolithic farmers. We have the genome of an LBK woman (Stuttgart) and a copper Age man from the Tyrol (Oetzi) and neither are lactose tolerant, or at least they don't carry the European version of the lactase persistence gene. (I wish they would release information about Gok 4).

That isn't to say that neolithic peoples weren't the ones who developed animal husbandry, because they were, as they were the ones to first process milk products into secondary products like cheese and perhaps butter and yoghurt.

The thing is that processed milk products contain much less lactose than liquid milk; half or less in a lot of cases, and sometimes only negligible amounts. (By the way, goat milk contains roughly the same amount of lactose as cow's milk, so if a population could drink goat milk, they could also drink cow's milk.) See:
http://no-lactose.com/pg,content-of-lactose,teneur,0,1.jsp

So, I doubt that Anatolian farmers were eating bowls of milk. They might very well have been eating bowls of soft cheeses or yoghurt like products, however, perhaps mixed with grains and fruits as you suggest. Or, they might initially have only made butter for use as a cooking fat, or as an unguent, a use to which it was put in the medieval period.

I think that leaves two possibilities: that the mutation occurred somewhere in Europe in a farming context, or that it was brought to Europe from migrating populations, perhaps, as Kamani suggests, from populations on the steppe that had interbred with people who carried it and were able to drink mare's milk.

When these carriers embraced a farming lifestyle, either at the edge of the steppe or in central Europe, with it's dependence on milk cattle, it was a natural fit. The peripheral mountainous areas or areas in the northwest that were not optimal for the original plant based neolithic package, were suitable for, and thus attracted these groups.

(Yes, the growth of cities meant a decrease in the consumption of liquid milk. However, I think the record is pretty clear that it was not a big part of the diet in medieval and Renaissance Europe either, whether because of poverty and the conditions of serfdom, or because of societal distrust of it. The consumption of butter and cheese is a different issue.)
 
http://www.nature.com/news/archaeology-the-milk-revolution-1.13471

I like their explanation. It states that a man was found in northern Germany who was lactose tolerant 6500 years ago (4500BC). A neolithic man. A man before the horse was domesticated. I guess that squishes the mare idea, which would explain low tolerance on the steppe for lactase. It looks like it formed in Hungary and became advantageous as a deterrent to famine. Southern Europe was populated by neolithic peoples before the mutation took hold and explains it's low frequency. I guess R1b was not responsible, and they either became LT or not based on where they migrated during the bronze age.
 
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So, I doubt that Anatolian farmers were eating bowls of milk. They might very well have been eating bowls of soft cheeses or yoghurt like products, however, perhaps mixed with grains and fruits as you suggest. Or, they might initially have only made butter for use as a cooking fat, or as an unguent, a use to which it was put in the medieval period.

I think that leaves two possibilities: that the mutation occurred somewhere in Europe in a farming context, or that it was brought to Europe from migrating populations, perhaps, as Kamani suggests, from populations on the steppe that had interbred with people who carried it and were able to drink mare's milk.

When these carriers embraced a farming lifestyle, either at the edge of the steppe or in central Europe, with it's dependence on milk cattle, it was a natural fit. The peripheral mountainous areas or areas in the northwest that were not optimal for the original plant based neolithic package, were suitable for, and thus attracted these groups.

(Yes, the growth of cities meant a decrease in the consumption of liquid milk. However, I think the record is pretty clear that it was not a big part of the diet in medieval and Renaissance Europe either, whether because of poverty and the conditions of serfdom, or because of societal distrust of it. The consumption of butter and cheese is a different issue.)

I don't think you can extrapolate from what Anatolian farmers or Italian serfs were eating in order to understand what Swedish peasants or Scottish crofters were eating. The regional differences, in terms of agricultural methods and socio-economic condtions, are just too great. So, as for the question of whether the mutation happened in Europe or was inherited from invaders from the steppes, I don't think we're any closer to having an answer as a result of all this discussion.
 
http://www.nature.com/news/archaeology-the-milk-revolution-1.13471

I like their explanation. It states that a man was found in northern Germany who was lactose tolerant 6500 years ago (4500BC). A neolithic man. A man before the horse was domesticated. I guess that squishes the mare idea, which would explain low tolerance on the steppe for lactase. It looks like it formed in Hungary and became advantageous as a deterrent to famine. Southern Europe was populated by neolithic peoples before the mutation took hold and explains it's low frequency. I guess R1b was not responsible, and they either became LT or not based on where they migrated during the bronze age.

Should I be right again. :shocked: I was guessing central/north europe about 7,000 ago. The time LP started to take off.
Still this mutation could have come from balkans with farmers or from steppe herders. There is an interesting line (one of maps) of LP going from europe through steppe to korea.
 
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I don't think you can extrapolate from what Anatolian farmers or Italian serfs were eating in order to understand what Swedish peasants or Scottish crofters were eating. The regional differences, in terms of agricultural methods and socio-economic condtions, are just too great. So, as for the question of whether the mutation happened in Europe or was inherited from invaders from the steppes, I don't think we're any closer to having an answer as a result of all this discussion.


I don't think so either...that's why I said even in speculating I couldn't choose between the two options...it will have to await more ancient dna studies.

As to the early Neolithic Anatolians, I was replying sceptically to Greying Wanderer's suggestion that they were consuming bowls of milk. Since LBK people would have been unable to consume it, I doubt their ancestors in Anatolia were able to do so.

With regard to Swedish peasants, we're going around in circles. The ones in at least middle and northern Sweden, like the Finns, were not consuming dairy products until very late in their history. (Apparently, no one was interested enough to read the links I provided.
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The studies were about England and Germany and Finland, not Italy.) The following are quotes from the Finland study:

" It is difficult to find a plausible scenario for an in situ selection process. Based on archaeological and historical data and genetic evidence (Itan et al. 2009; Malmström et al. 2010) we suggest that the observed high frequencies of LP variant C/T-13910 in Northern Europe can best be explained by strong directional selection that took place in Central Europe and was followed by a migration of people representing this culture to Northern Europe.The immigrants gradually re-placed the local hunter-gatherer populations. The genetic evidence for suchimmigration and assimilation has been found in Sweden, while in Finland archaeological evidence clearly indicates a change in material culture following a population bottleneck (Malmström et al. 2010; Sundell et al. 2010)."

The lack of support for an in situ development of lactase persistence is explained below.

"It is noteworthy that gene-culture co-evolution hypothesis for LP only appies to cultires in which fresh unfermented milk was consumed by both children and adults on a regular basis or at least during periods critical for survival. Importantly, consumption of fermented milk products alone could not have been a strong enough selective pressure for LP to become prevalent as even adults with hypolactasia are usually able to consume fermented milk products.


According to the ethnographic sources, in the Finnish traditional agriculture fresh milk was only consumed by children of one to two years of age during the 18th and 19th centuries (Talve 1997;Vuorela 1998).Adults did not consume fresh milk as such, but predominantly fermented sourmilk, usually mixed with water, or occasionally in soups .

The historical sources from earlier periods seem to describe similar practices, as no milk or milk products except some butter and possibly small amounts of buttermilk were mentioned as a part of daily diet in the 16th-century Hämeenlinna Castle in Finland(Vilkuna 1998). Butter was an important taxation item. In Sweden, newborn calves were only allowed to suck their mothers for a few days, and were there-after fed skimmed milk; nearly all cream was used for making butter.

Second, even if adults had a preference for fresh milk, not enough milk was available for regular consumption. Cattle herding was neither widespread nor productive enough in Northern Europe to provide constant access to fresh milk.

In Finland, the earliest reliably dated domestic animal bones date to the Bronze Age, and even then they are found in restricted numbers in a restricted coastal area. It seems that in Finland, animal husbandry established itself as an important source of household economy not earlier than in the Iron Age (500 BCE to CE.

Before the adoption of hay cultivation, cattle could only be milked during the grazing period, usually from May to October in both Sweden and Finland (Myrdal 1999; Soininen 1974). In the 18th and 19th cen-turies milk yields were still modest, on the average only 400 to 500 liters of milk per year and per animal, compared to modern commercial dairy cows that produce 6,000 to 7,000 liters per year (Björnhag and Myrdal 1994). Finnish
farmers kept livestock mainly for haulage power in fieldwork and transport, and for manure to fertilize the fields (Soininen 1974). Animal energy and manure were thus the main products, with milk only a secondary product. During the longwinter feeding period (six to eight months), poor quality fodder (mainly straw) was often used, with the result of serious undernourishment in animals in both Sweden and Finland.

Corded Ware people have been connected to pastoralism in other parts of the Europe; it seems possible that they were carrying the T-13910allele, even if cattle breeding may not have been a major component in their economy in Finland. During the Bronze Age and Early Iron Age, there was also likely immigration to Finland from Sweden and the Baltic countries, but the magnitude of this migration is unknown."

Ed. Perhaps I am imagining things, in which case I apologize, but it seems to me that I detect some antagonism to my posts on this issue. I truly don't understand why that should be the case. I thought we were having a quasi scientific-historical discussion about the development of lactase persistence, and whether the consumption of large quantities of it in pre-history or even in the middle ages could be correleated with areas with high levels of the gene and high consumption today.

We're only talking about a food after all. Why should it be such an emotional issue?
 
I don't know if this was brought up, but I wonder how the domestication of the horse, and the use of mare milk contributed to lactose tolerance? I know that mare milk has twice the lactose, than cow or goats milk. If R1b and R1a were Steppe people, than maybe they developed it to survive off of horse meat and mare milk, where agriculture was not possible or very unreliable. Early attempts of agriculture was tough in northern climates, and often failed. So, maybe these horse riders who adapted to drinking mare milk (or partly fermented) brought their LT to Europe where they engaged in cattle pastoralism in the north and were already suited for cows milk.

if you read my previous post you will have partial response and Didier like me think that R1b is causing a consumer mare's milk, and it's coming to Europe he converted to cow's milk. We find the old riding vocabulary among Basque but also very old tradition in Ireland, which are ancient peoples who kept alive their culture and traditions. (We know that the Basque were the earliest known still spoken today R1b ​​language)
Current cows are from europe and africa and domestic horses are coming from Siberia and Europe. Read Didier is his job genetics and animals.

You will also see the simplified method to calculate Kliuzov time according to the number of mutation and generation time, which according to my calculations gives 12,000 years R1a and R1b to 14,000, because I believe that women were breeding between 20/25 years and not 25/35.
cattle born in three places, could be the oldest in Africa (10,000 years), then India and finally in Europe at the end of the Neolithic, it is a genetic reality and not speculation.
 
http://www.nature.com/news/archaeology-the-milk-revolution-1.13471

I like their explanation. It states that a man was found in northern Germany who was lactose tolerant 6500 years ago (4500BC). A neolithic man. A man before the horse was domesticated. I guess that squishes the mare idea, which would explain low tolerance on the steppe for lactase. It looks like it formed in Hungary and became advantageous as a deterrent to famine. Southern Europe was populated by neolithic peoples before the mutation took hold and explains it's low frequency. I guess R1b was not responsible, and they either became LT or not based on where they migrated during the bronze age.

I think you may have linked the wrong study? This has to do with the discovery of implements used for cheese making in a neolithic culture of that time, not the discovery of a man carrying the lactase persistence gene. You don't need the gene to consume cheese.
 
@Angela

"As to the early Neolithic Anatolians, I was replying sceptically to Greying Wanderer's suggestion that they were consuming bowls of milk. Since LBK people would have been unable to consume it, I doubt their ancestors in Anatolia were able to do so."

I didn't say Anatolia. I said Atlantic coast and northwest Europe i.e. the regions with the highest rates of LP now.

edit: Re-reading I said "Atlantean" which probably caused the confusion.


@Aberdeen

"
I feel better when I have more dairy in my diet. And although my Y haplotype is I1, I can't help but wonder how many of my indirect paternal ancestors were R1b."

The highest rates of LP overlap with the highest rates of I1. It's not just a descended from R1b thing. It's a descended from [regions where milk was a particularly critical part of the diet in the neolithic] thing.

http://img534.imageshack.us/img534/6959/lactose.png

http://2.bp.blogspot.com/-lhXgXOSp_a0/UKljuK_d9AI/AAAAAAAAABM/gB_lmZj0Jqc/s1600/792px-Distribution_Haplogroup_I_Y-DNA.svg.png



 
see articles by Didier is geneticist. Also, the mtDNA groups H1, H3, T1 are very present in the highest LP population : Basque, English, Irish, Scandinavian.


The authors note (thanks to STR markers) 2 founder effects leading to a fairly homogeneous group of Y1 and Y2 share 'Alpine'. Varieties 'Y1' are dairy breeds it is tempting to see the trace of Y1 banded stand with subsequent migration notament Vikings. The Alpine Y2 pole indicates a cross-strain Auroch most recently with a 'European' but then a strong selection for oriented meat production and animal traction (plow, fork) races. The authors seem to ignore the cultural border crossing to France: north traction Horse (Ardennes etc ...) and to the south by Oxen traction. The meat selection corresponds to the location pastures even if the use of milk (cheese) is also well known. Can be considered as the Alpine Y2 group R1b-U152, probably with a broadcast. The case of the Iberian Y2 seems different and can be connected to a tradition of 'brave bulls' (racing type bulls of Pamplona) probably involving frequent crossings' Auroch.

The analysis of autosomal SNPs 44700 allows authors to firstly find that different strains analyzed clearly divided into 3 groups: Europe, India and Africa. There
So 3 poles domestication. Then, focusing on the French strains and some European strains, it was possible to identify four subgroups


http://www.chezdidier.org/article-la-domestication-de-bos-taurus-107951377.html

http://www.chezdidier.org/article-un-illustre-inconnu-107662828.html



http://a141.idata.over-blog.com/3/98/35/94/carte-Y-boeuf.png

Are the breeds marked in green the dairy breeds?
 
Yes ! the race for meat closer to the Auroch but the mestizo who give European dairy cows. You can still see the difference today
and it is in Europe that are created Varietal dairy with lactose intake at the time of europeanNeolithic

That might tie in with this

http://forwhattheywereweare.blogspot.co.uk/2014/02/neolithic-peoples-from-britain-and.html

I think some population along the Atlantic coast developed a cattle-centric culture to compensate for poor crops in the Atlantic climate and that culture opened up a previously unfilled niche allowing a dramatic population increase.

And apparently there was a large population increase associated with megalithism.

http://forwhattheywereweare.blogspot.co.uk/2014/02/neolithic-and-chalcolithic-demographics.html

http://4.bp.blogspot.com/-Gng3kY_iY.../wvKMxjZv94Q/s1600/gendemographyannotated.jpg

This isn't necessarily anything to do with LP directly but if a cattle-centric culture developed along the Atlantic coast then it would be the perfect place for LP to spread once it arrived.
 
I think you may have linked the wrong study? This has to do with the discovery of implements used for cheese making in a neolithic culture of that time, not the discovery of a man carrying the lactase persistence gene. You don't need the gene to consume cheese.

"Burger has looked for the mutation in samples of ancient human DNA and has found it only as far back as 6,500 years ago in northern Germany." a quote from the article

He not talking about cheese making, he talking about the allele.
 
"Burger has looked for the mutation in samples of ancient human DNA and has found it only as far back as 6,500 years ago in northern Germany." a quote from the article

He not talking about cheese making, he talking about the allele.

You're right. The article is about the cheese making implements, but that quote does appear. I just thought you meant to link the Burger study which discussed finding the allele.
 
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