genetics

  1. Maciamo

    HLA-DR14 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR14. The maximum frequencies are observed in Kosovo (8.5%), Albania (7.5%), South Italy (7.5%), Georgia (7.5%), Romania (7%), Macedonia (6.7%), Greece (6.5% but 4% in Crete), Armenia (6.5%). DR14 is virtually absent from the Sardinian, Basque...
  2. Maciamo

    HLA-DR10 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR10. The maximum frequencies are observed in the Lebanon (5.2%), Saudi Arabia (4.8%), Palestine (4.7%), Jordan (3.8%), Morocco (3.3%), Algeria (3%), Tunisia (3%), and oddly enough also among the Saami people (2.9%). It is absent from the Basque...
  3. Maciamo

    HLA-DR13 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR13. Unlikely most other HLA types, DR13 does not show any specific geographic pattern or associated with ethnic groups or Y-DNA haplogroup. This is because DR13 is in fact divided in three major subclades and patterns are only meaningful within...
  4. Maciamo

    HLA-DR9 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR9. It is overall an North Asian HLA type, although it is also found in Lebanon and the Maghreb (but Lebanese do have 1-2% of North Asian DNA associated with Y-DNA haplogroup Q1b). The maximum frequencies are observed among the Saami (7 to 16%...
  5. K

    p raw value vs. p genome value?

    So I'm reading a scientific article about dog genetics and it gives me 2 p-values for a value that is statistically significant. One is a nominal p-value (praw) and the other is a p-value corrected by permutation testing (pgenome). Could someone please tell me the difference between these two...
  6. Maciamo

    SNPs linked to HLA-DR types in Europeans/Caucasians

    The HLA gene regulates our acquired immune system. It is what helps our body identify foreign antigens (bacteria, fungi, viruses) and determine what type of white blood cells and antibodies should be produced. Depending on our HLA type we are more or less resistant to certain diseases and...
  7. Maciamo

    HLA-DR7 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR7. The maximum frequencies are observed in the Basque country (26 to 31%), northern Catalonia (23%), the Balearic Islands (22%), Cantabria (20%), Tunisia (19%), Saudi Arabia (18%), Andalusia (17.5%), Libya (17%), and in Ireland (16%). You...
  8. Maciamo

    HLA-DR15: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR15. The maximum frequencies are observed in the Pasiegos of Cantabria in northern Spain (32%), the Chuvash of the Volga region (19.5%), Ireland (18.5%), Denmark (18.5%), Brittany (18%), Orkney (18%), Norway (15.5%) and Sweden (15.5%). DR15...
  9. Maciamo

    HLA-DR3 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR3. The maximum frequencies are observed in Sardinia (56%), the Basque country (19.5%), Ireland (18%), Morocco (16.5%), Tunisia (16.5%), Libya (15.5%), Saudi Arabia (15.5%), Belgium (15.5%), Wales (15%), Algeria (15%), England/Scotland (14.5%)...
  10. Bosnian Boss

    Genetic information for Bosnia and Herzegovina?

    Hello again! If somebody would be so willing as to provide a summary on the genetics of Bosnians (all 3 major ethnicities), it would be greatly appreciated! :good_job: I've done some research on my own and have seen conflicting or sparse data, as the region is overlooked, as per usual. Outside...
  11. Maciamo

    HLA-DR16: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR16. The maximum frequencies are observed in the United Emirates (18%), Bulgaria (17.5%), Macedonia (15.5%), Greece (13.5%), Albania (12.5%), Serbia (11%), Croatia (10.5%) and Sardinia (10.5%). It is completely absent from the Saami, Breton...
  12. LeBrok

    Y haplogroups correlation with number of sons, R1b, I2a-Din, E-V13, G2a

    This possible phenomenon was discussed in many threads, as an explanation to why some Y haplogroups became so dominant. Maciamo's hypothesis about dominance of R1b clades in Western Europe is based on it too. This hypothesis states that males of certain haplogroups, like R1b, or some of its...
  13. 2

    Why Human

    As philosophers, historians, and wise old men and women would have us know, people are born with certain things about them that make them "human". Yes, of course, we all have the genetic build that is standard for us to biologically be human and not bird or bug. What I mean when I say they...
  14. S

    GM food- forbidden or not?

    I believe that most of you may know the event that Scottish government announced a ban for GM corps to protect the environment of Scotland. If you don't, you can search Scottish, GM food, and I think you can find many news about this. So here is the argument: what is your opinion about GM food...
  15. Maciamo

    Y-DNA and mtDNA frequencies in Proto-Indo-European cultures

    I have added the samples from Allentoft 2015 and updated the haplogroup frequencies in the section Haplogroups of Bronze Age Proto-Indo-Europeans.
  16. Maciamo

    HLA-DR1: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DR1. The maximum frequencies are observed in the Volga-Ural region, among the Mari (24%), Chuvash (18.5%), Kostroma Russians (17.5%) and South Ural Russians (16%). Subtypes There are three main subclades of DR1: - DRB1*01:01 : the vast...
  17. Maciamo

    HLA-A3: distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-A3, which is divided in two subtypes : A3:01 and A3:02. The former is mostly found in Europe, with lower frequencies across the Middle East, Central Asia (Uygurs), India and even isolated parts of Africa (Cameroon). The latter peaks in Georgia...
  18. Maciamo

    HLA-DQ8 : distribution map, subtypes, SNPs and associated medical conditions

    Here is a map showing the allele frequency of HLA-DQ8. The world's highest frequencies are observed in Central and South America (up to 80%), then in Siberia (11-22%). It has been suggested that a migration from people east of the Urals is responsible for DQ8. The strongest association with...
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