Genetically inherited traits, conditions and diseases
What can DNA tell you about yourself ?
List of auto-immune diseases with the associated genes
=> 17 diseases and 148 SNP's listed.
Risk alleles : Substantially lower risk
(over 3x less), moderately lower risk (up
to 3x less), normal, slightly higher
risk (up to 3x more), greatly increased risk
(over 3x more). Normal alleles marked
with a * mean that the person is a carrier of the disease. Depending on
the testing company, sometimes A is reported as T, and G is reported as
C, or vice-versa. Question marks (?) mean that we doubt the validity of
the risk alleles because they are too common.
Testing companies : 1 = 23andMe
; 2 = DeCODEme
Bold numbers indicate that the SNP is part of the official report, and
is therefore likely to be more reliable. Only SNP's in the official report
are listed for deCODEme. However, as deCODEme tests almost twice more
SNP's than 23andMe, most of the SNP's tested by 23andMe are also tested
by deCODEme.
| Description |
Chromosome
|
Gene
|
SNP
|
Risk alleles
|
Tested by*
|
Links
|
| |
|
|
|
|
|
|
| Allergies (general) |
1
|
FCER1A
|
rs2427837
|
AA, AG,
GG
|
|
|
| |
|
|
rs2251746
|
CC, CT,
TT
|
1
|
|
| Ankylosing
Spondylitis |
5
|
ARTS-1
|
rs27044
|
CC, CG, GG
|
1
|
|
| |
|
|
rs17482078
|
CC, CT, TT
|
|
|
| |
|
|
rs10050860
|
CC, CT, TT
|
1
|
|
| |
|
|
rs30187
|
CC, CT, TT
|
1
|
|
| |
|
|
rs2287987
|
CC, CT,
TT
|
|
|
| |
1
|
IL23R
|
rs11209026
|
AA, AG,
GG
|
1
|
|
| |
|
|
rs1004819
|
CC, CT, TT
|
1
|
|
| |
|
|
rs10489629
|
AA, AG, GG
|
1
|
|
| |
|
|
rs11465804
|
GG, GT,
TT
|
1
|
|
| |
|
|
rs1343151
|
CC, CT, TT
|
1
|
|
| |
|
|
rs10889677
|
AA, AC,
CC
|
1
|
|
| |
5
|
LNPEP
|
rs2303138
|
AA, AG,
GG
|
1
|
|
| |
6
|
-
|
rs7743761
|
AA, AC,
CC
|
1
|
|
| |
12
|
CLSTN3
|
rs7302230
|
AA, AG, GG
|
1
|
|
| Asthma |
1
|
intergenic
|
rs4950928
|
CC, CG, GG
|
1
|
|
|
6
|
PLA2G7
|
rs1805018
|
|
1, 2
|
|
|
|
|
rs1051931
|
|
1, 2
|
|
| |
6
|
TNF
|
rs1800629
|
AA, AG,
GG
|
1
|
|
|
7
|
AAA1
|
rs324981
|
|
1
|
|
| |
11
|
GSTP1
|
rs1695
|
AA, AG, GG
|
1, 2
|
|
| |
17
|
GSDML
|
rs7216389
|
CC, CT, TT
|
1, 2
|
|
| Celiac
Disease |
1
|
RGS1
|
rs2816316
|
|
1, 2
|
|
| |
2
|
intergenic
|
rs917997
|
CC, CT, TT
|
1, 2
|
|
| |
3
|
intergenic
|
rs6441961
|
|
1, 2
|
|
| |
3
|
intergenic
|
rs17810546
|
AA, AG, GG
|
1, 2
|
|
| |
3
|
LPP
|
rs1464510
|
|
1, 2
|
|
| |
4
|
KIAA1109
|
rs13119723
|
|
1
|
|
| |
4
|
intergenic
|
rs6822844
|
GG, GT, TT
|
1, 2
|
|
| |
6
|
HLA-DQA1
|
rs2187668
|
CC, CT,
TT
|
1, 2
|
|
| |
6
|
TAGAP
|
rs1738074
|
AA, AG, GG
|
1, 2
|
|
| |
12
|
SH2B3
|
rs3184504
|
CC, CT, TT
|
1, 2
|
|
| |
19
|
MYO9B
|
rs2305764
|
AA, AG, GG
|
1
|
|
| |
|
|
rs2305767
|
CC, CT, TT
|
1
|
|
| Crohn's
Disease |
1
|
IL23R
|
rs11209026
|
AA, AG,
GG
|
1, 2
|
|
| |
|
|
rs11805303
|
CC, CT,
TT
|
1
|
|
| |
2
|
ATG16L1
|
rs2241880
|
AA, AG, GG
|
1, 2
|
|
| |
|
|
rs10210302
|
CC, CT,
TT
|
1
|
|
| |
3
|
BSN
|
rs9858542
|
AA, AG, GG
|
1, 2
|
|
| |
3
|
MST
|
rs3197999
|
AA, AG, GG
|
1
|
|
| |
5
|
5p13 region
|
rs17234657
|
GG, GT,
TT
|
1, 2
|
|
| |
5
|
IBD5
|
rs12521868
|
|
1, 2
|
|
| |
5
|
IRGM
|
rs4958847
|
AA, AG, GG
|
1, 2
|
|
| |
|
|
rs7714584
|
AA, AG, GG
|
1
|
|
| |
6
|
TNF
|
rs1800629
|
AA, AG,
GG
|
1
|
|
| |
7
|
ABCB1
|
rs3789243
|
|
1
|
|
| |
10
|
NKX2-3
|
rs11190140
|
CC, CT, TT
|
1, 2
|
|
| |
10
|
intergenic
|
rs10761659
|
AA, AG, GG
|
1
|
|
| |
10
|
intergenic
|
rs224136
|
CC, CT, TT
|
1, 2
|
|
| |
11
|
NELL1
|
rs1519717
|
|
1, 2
|
|
| |
|
|
rs1793000
|
|
1, 2
|
|
| |
16
|
NOD2(1)
|
rs2066844
|
CC, CT, TT
|
1
|
|
| |
16
|
NOD2(2)
|
rs2066845
|
CC, CG,
GG
|
1
|
|
| |
|
|
rs2066843
|
|
1, 2
|
|
| |
16
|
NOD3(3)
|
rs2066847
|
|
1
|
|
| |
18
|
PTPN2
|
rs1893217
|
AA, AG, GG
|
1
|
|
| |
|
|
rs2542151
|
GG, GT,
TT
|
1, 2
|
|
| |
22
|
XBP1
|
rs35873774
|
|
|
|
| Type-1
Diabetes |
1
|
PTPN22
|
rs2476601
|
|
1
|
|
| |
|
|
rs6679677
|
|
1, 2
|
|
| |
2
|
CTLA4
|
rs3087243
|
|
1
|
|
| |
|
|
rs11571316
|
|
1
|
|
| |
|
|
rs231804
|
|
1, 2
|
|
| |
2
|
IFIH1
|
rs1990760
|
|
1, 2
|
|
| |
4
|
intergenic
|
rs6822844
|
|
1, 2
|
|
| |
6
|
HLA
|
rs3129934
|
|
1, 2
|
|
| |
|
|
rs9272346
|
|
1
|
|
| |
10
|
IL2RA
|
rs2104286
|
|
1, 2
|
|
| |
11
|
INS
|
rs3741208
|
|
1, 2
|
|
| |
12
|
SH2B3
|
rs3184504
|
|
1
|
|
| |
12
|
C12orf30
|
rs17696736
|
|
1, 2
|
|
| |
12
|
ERBB3
|
rs2292239
|
|
1, 2
|
|
| |
16
|
KIAA0350
|
rs725613
|
|
1, 2
|
|
| |
18
|
PTPN2
|
rs1893217
|
|
1
|
|
| |
|
|
rs2542151
|
|
1, 2
|
|
| Type-2
Diabetes |
1
|
NOTCH2
|
rs2793831
|
|
1, 2
|
|
| |
2
|
THADA
|
rs7578597
|
|
1, 2
|
|
| |
3
|
PPARG
|
rs1801282
|
|
1, 2
|
|
| |
|
|
rs6802898
|
|
1
|
|
| |
|
|
rs2197423
|
|
1
|
|
| |
3
|
IGF2BP2
|
rs4402960
|
|
1, 2
|
|
| |
4
|
WFS1
|
rs10012946
|
|
1
|
|
| |
5
|
ADRB2
|
rs1042714
|
|
1
|
|
| |
6
|
CDKAL1
|
rs4712523
|
|
1
|
|
| |
|
|
rs7756992
|
|
1, 2
|
|
| |
7
|
JAZF1
|
rs1635852
|
|
1, 2
|
|
| |
8
|
SLC30A8
|
rs13266634
|
|
1, 2
|
|
| |
9
|
CDKN2A/B
|
rs2383208
|
|
1, 2
|
|
| |
9
|
intergenic
|
rs10811661
|
CC, CT, TT
|
1
|
|
| |
10
|
TCF7L2
|
rs7903146
|
|
1, 2
|
|
| |
|
|
rs7901695
|
|
1
|
|
| |
10
|
HHEX
|
rs1111875
|
|
1, 2
|
|
| |
|
|
rs5015480
|
|
1
|
|
| |
11
|
KCNJ11
|
rs5219
|
|
1
|
|
| |
|
|
rs5215
|
|
1, 2
|
|
| |
12
|
intergenic
|
rs1353362
|
|
1, 2
|
|
| Graves'
disease |
1
|
FCRL3
|
rs7528684
|
|
1
|
|
| |
1
|
IL23R
|
rs10889677
|
|
1
|
|
| |
|
|
rs2201841
|
|
1
|
|
| |
|
|
rs7530511
|
|
1
|
|
| |
1
|
RSBN1
|
rs3789604
|
|
1
|
|
| |
2
|
CTLA4
|
rs231775
|
|
1
|
|
| |
|
|
rs733618
|
|
1
|
|
| |
6
|
ITPR3
|
rs3748079
|
|
1
|
|
| |
6
|
TNF
|
rs1799964
|
|
1
|
|
| |
|
|
rs1800630
|
|
1
|
|
| |
|
|
rs1800629
|
AA, AG,
GG
|
1
|
|
| Hyperparathyroidism |
11
|
MEN1
|
rs2959656
|
|
|
|
| |
1
|
CDC73
|
rs28942098
|
|
1
|
|
| |
3
|
CASR
|
rs28936684
|
|
1
|
|
| Hypothyroidism |
9
|
FOXE1
|
rs28937575
|
|
1
|
|
| Hypothyroidism (goiter) |
8
|
TG
|
rs2069556
|
|
1
|
|
| |
|
|
rs11535853
|
|
1
|
|
| |
|
|
rs2069561
|
|
1
|
|
| |
|
|
rs35301433
|
|
|
|
| |
|
|
rs853326
|
|
1
|
|
| Inflammatory
bowel disease |
2
|
IL1B
|
rs1143634
|
CC, CT, TT
|
1
|
|
| Multiple
Sclerosis |
1
|
RPL5
|
rs6604026
|
CC, CT,
TT
|
1
|
|
| |
1
|
CD58
|
rs12044852
|
AA, AC, CC
|
1
|
?
|
| |
1
|
FAM69A
|
rs7536563
|
AA, AG,
GG
|
1
|
?
|
| |
|
|
rs11164838
|
CC, CT, TT
|
1
|
?
|
| |
1
|
EVI5
|
rs10735781
|
CC, CG, GG
|
1
|
?
|
| |
|
|
rs6680578
|
AA, AT, TT
|
1
|
?
|
| |
1
|
PDE4B
|
rs1321172
|
CC, CG, GG
|
1
|
|
| |
2
|
ALK
|
rs7577363
|
AA, AG,
GG
|
1
|
|
| |
3
|
CBLB
|
rs12487066
|
CC, CT, TT
|
1
|
?
|
| |
5
|
IL7RA
|
rs6897932
|
CC, CT, TT
|
1, 2
|
|
| |
6
|
HLA-DRB1
|
rs3135388
|
AA, AG,
GG
|
1, 2
|
|
| |
7
|
IRF5
|
rs3807306
|
|
1
|
|
| |
7
|
intergenic
|
rs4728142
|
|
1
|
|
| |
9
|
DBC1
|
rs10984447
|
AA, AG,
GG
|
1
|
?
|
| |
9
|
ANKRD1
|
rs10975200
|
AA, AG, GG
|
1
|
|
| |
10
|
IL2RA
|
rs12722561
|
CC, CT, TT
|
1, 2
|
?
|
| |
|
|
rs12722489
|
AA, AG, GG
|
1
|
?
|
| |
|
|
rs2104286
|
AA, AG, GG
|
1
|
?
|
| |
12
|
LAG3
|
rs870849
|
|
1
|
|
| |
12
|
KLRB1
|
rs4763655
|
AA, AG, GG
|
|
|
| |
14
|
KLC1
|
rs8702
|
CC, CG, GG
|
|
|
| |
16
|
KIAA0350
|
rs6498169
|
AA, AG, GG
|
1
|
|
| Psoriasis |
1
|
IL23R
|
rs11209026
|
AA, AG,
GG
|
1, 2
|
|
| |
|
|
rs2201841
|
AA, AG, GG
|
1
|
|
| |
1
|
intergenic
|
rs4112788
|
AA, AG, GG
|
1
|
|
| |
1
|
intergenic
|
rs4085613
|
GG, GT,
TT
|
1
|
|
| |
5
|
IL12B
|
rs3212227
|
GG, GT,
TT
|
1, 2
|
|
| |
|
|
rs3213094
|
CC, CT,
TT
|
1
|
|
| |
5
|
IL13
|
rs20541
|
AA, AG, GG
|
1
|
|
| |
6
|
PSORS1C3
|
rs887466
|
|
1
|
|
| |
6
|
HLA-Cw0602
|
rs1265181
|
CC, CG, GG
|
|
|
| |
6
|
HLA-C
|
rs1265159
|
AA, AG,
GG
|
1
|
|
| |
6
|
HLA-C
|
rs10484554
|
CC, CT,
TT
|
1, 2
|
|
| |
6
|
TNF
|
rs361525
|
AA, AG,
GG
|
1
|
|
| |
6
|
TNFAIP3
|
rs610604
|
GG, GT,
TT
|
1
|
|
| |
12
|
STAT2
|
rs2066808
|
AA, AG,
GG
|
1
|
|
| Rheumatoid
Arthritis |
1
|
PTPN22
|
rs2476601
|
AA, AG,
GG
|
1, 2
|
|
| |
1
|
PADI4
|
rs11203366
|
AA, AG, GG
|
1
|
|
| |
|
|
rs2240340
|
AA, AG,
GG
|
1
|
|
| |
1
|
MMEL1
|
rs3890745
|
CC, CT, TT
|
1
|
|
| |
|
|
rs6684865
|
AA, AG, GG
|
1
|
|
| |
1
|
FCRL3
|
rs7528684
|
AA, AG, GG
|
1
|
|
| |
1
|
RSBN1
|
rs6679677
|
|
1
|
|
| |
1
|
intergenic
|
rs11162922
|
|
1
|
|
| |
2
|
STAT4
|
rs7574865
|
|
1, 2
|
|
| |
2
|
CTLA4
|
rs3087243
|
|
1
|
|
| |
2
|
ITGAV
|
rs3738919
|
|
1
|
|
| |
4
|
intergenic
|
rs6822844
|
|
1, 2
|
|
| |
4
|
ANAPC4
|
rs3816587
|
|
1
|
|
| |
6
|
HLA-DRB1
|
rs6457617
|
CC, CT,
TT
|
1, 2
|
|
| |
6
|
6q23
|
rs2327832
|
AA, AG, GG
|
1, 2
|
|
| |
|
|
rs13192841
|
|
1, 2
|
|
| |
6
|
intergenic
|
rs6920220
|
|
1
|
|
| |
7
|
IRF5
|
rs2004640
|
|
1
|
|
| |
7
|
intergenic
|
rs11761231
|
|
1
|
|
| |
9
|
TRAF1/C5
|
rs3761847
|
AA, AG, GG
|
1, 2
|
|
| |
9
|
intergenic
|
rs10818488
|
|
1
|
|
| |
9
|
PHF19
|
rs1953126
|
|
1
|
|
| |
10
|
IL2RA
|
rs2104286
|
|
1
|
|
| |
13
|
intergenic
|
rs9550642
|
|
1
|
|
| |
21
|
intergenic
|
rs2837960
|
|
1
|
|
| |
22
|
intergenic
|
rs743777
|
|
1
|
|
| Sjögren's
Syndrome |
2
|
STAT4
|
rs7574865
|
GG, GT, TT
|
1
|
|
| Systemic
Lupus Erythematosis (Lupus) |
2
|
STAT4
|
rs7574865
|
GG, GT,
TT
|
1
|
|
| |
6
|
HLA-DQA1
|
rs2187668
|
CC, CT,
TT
|
1
|
|
| |
6
|
TNF
|
rs1800629
|
AA, AG,
GG
|
1
|
|
| |
7
|
IRF5
|
rs10488631
|
CC, CT,
TT
|
1
|
|
| |
16
|
ITGAM
|
rs9888739
|
CC, CT,
TT
|
1
|
|
| Ulcerative
colitis |
1
|
ECM1
|
|
|
|
|
| |
1
|
RUNX3
|
rs2236851
|
|
|
|
| |
2
|
IL1B
|
rs1143634
|
CC, CT, TT
|
1
|
|
| |
2
|
IL1RN
|
rs423904
|
|
|
|
| |
5
|
PTPRS
|
|
|
|
|
| |
7
|
ABCB1
|
rs3789243
|
|
1
|
|
| |
7
|
MDR1
|
|
|
|
|
|
